Estrogel has no benefit, it is not able to compete with dihydrotestosterone for receptors.
It has helped me. and in Europe topical 17 a- estradiol is approved to treat women with hairloss.
"Hair counts and diameter from baseline to 4 and 8 months after treatment increased in treated patients and these changes were statistically significant (
p<0.0001). 17α-estradiol (Ell-Cranell® alpha 0.025%) solution showed significant improvement by subjective self-assessment and by investigator photographic assessment. "
Whatevr, also improved with topical Albicort-F
Of course this depends how much gets absorbed. male skin is thicker than female skin and bald scalp has fibrosis, increased elastin fibers
but raising estradiol levels has multiple benefit:
It raises SHBG, which makes DHT less bioavailable in the blood. It reduces testosterone production.
and it inhibits to some extant 5ar in the scalp:
(100 nM 17alpha-E: 20%; 100 nM 17beta-E: 60%)
https://www.ncbi.nlm.nih.gov/pubmed/11358723
but it doesn't inhibit it directly like finasteride or dutasteride does, they think some indirect effects cause this..
If you want to inhibit maximum 5AR without f*****g the liver then we need to combine dutasteride, estradiol and progesterone. Then there are 3 different mechanisms of methods of 5ar reduction. dutasteride alone has a dose dependence curve, 2.5mg to 5mg won't inhibit 5ar 100%. it gets very close but it plateaus out at after 2.5mg, there is no difference betwen 2.5mg and 5mg dutasteride. also, I hear so many people who use high dose dutasteride and it works but years later stops working.
If estradiol causes a change in the body, then after the cancellation, everything will come back.
this is not true. If gyno gets too developed then it is permanent.. also if you take hormones a long time and balls shrink. They may not come back completely all the way after stopping treatment.