So I have IBD (inflammatory bowel disease) and I've noticed now that every single time I take a break from taking estrogen my IBD gets way worse. I started to wonder so I did some research and apparently estrogen can actually help control inflammation.
"Estrogen has an anti-
inflammatory effect in the body. When
estrogen levels decline, chronic
inflammation symptoms are increased. Many patients experience a decrease in their joint pain when their
hormones are balanced. ... As a result, thickening of the lining inside the joints occur,
causing pain and swelling."
https://derosamedical.com/did-you-know-the-connection-between-low-estrogen-and-arthritis/
What sucks is that I finally got off of a dangerous drug prednisone last summer. I thought it was because I started using cbd oil but I also started using estrogen at the same time so now I am thinking maybe the cbd oil does nothing at all or very little and it has actually been the estrogen that was helping the whole damn time. Now I feel really conflicted. My life sucks right now. I have constant stomach pain and discomfort, I am constantly going to the bath room. I honestly feel like going back on estrogen right now just to improve my IBD. I don't know what to do, my gyno will get worse again but I'm so tired of my f*****g stomach pain all the time. I dont want to go back on prednisone because it is very dangerous long term plus it bloats the hell out of my face and makes me look like a damn chipmunk. I think I might take some e tonight. I was planning on staying off of it for much longer but i'm so tired and weak right now. I can't believe probably the only reason my disease has been getting better is the damn estrogel i've been using. I'm desperate here buy maybe there is a chance that staying on a low dose of e my gyno will never get any worse. I've read many accounts of trans women who said their breast growth stopped completely until they upped their estrogen dose considerably. So f*** I don't know. I feel like sh*t. I think I'm just gonna try going back on a smaller dose and pray my gyno never gets any worse.
If any of you guys know someone with ibd, please have a little sympathy. Sometimes when I tell people what I have they seem to brush it off like I just told them I have asthma. I don't think people realize how debilitating, depressing and isolating it can be.
Here is some more research for anyone interested.
"Growing evidence from epidemiological and experimental studies suggests a role for estrogens, particularly 17β estradiol, in IBD pathogenesis [
4-
14]. Estrogens have been shown to finely regulate inflammation [
15] and have been implicated in the modulation of several immune-mediated diseases"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747344/
"Symptoms of IBD fluctuate considerably over time and often flare at times of hormonal changes, such as puberty, pregnancy, and menopause,
2 suggesting a potential involvement of steroid hormones such as 17β estradiol (estrogen), prolactin, and testosterone in the pathogenesis of this disease."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924746/