Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Don't you think that just bicalutamide is enough? Bica is really strong... I think. You'll get breast easily (but small) on it.
Bica >>> spironolactone
I think you need to delete spironolactone from your future regimen.
CPA can cause depression (and liver problems) with high dosage (25-300 mg).
I wouldn't use spironolactone if I decide to not use oral minoxidil. Unfortunately, oral minoxidil has the potential to cause water retention so using spironolactone would combat that effect. I am definitely unsure about oral minoxidil, however... I am fearful of becoming dependant on it.
Do you use bicalutamide orally? I see that you use it in your regimen. What has your experience been?
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You can think a lot of that. another thing is practice. I have not yet seen any good results for bicalutamide and spironolactone.
Bicalutamide is used less commonly, however the limited amount of people who do use it experience better results as far as feminisation compared to spironolactone and CPA (e.g. body hair loss, breast growth). When it comes to hair loss, I have seen particular transgenders who experienced significant regrowth and there was @Ein who uses bicalutamide and has experienced great results. I have seen several great results with spironolactone, I'll link some in particular: https://www.hairlosstalk.com/interact/threads/you-might-be-interested-in-reading-this.110443/ https://www.hairlosstalk.com/intera...teride-but-now-looking-for-a-new-cure.110277/ https://www.hairlosstalk.com/intera...16-nw3-at-19-now-22-with-norwood-0-5-1.65485/ http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=109546
When it comes to these medications, I mainly rely on the experience of transgender people since they use these medications. Whether it's spironolactone, cyproterone acetate or bicalutamide, transgenders experience the effects of potent anti-androgens from all of them. It just depends on which one suits you, I guess...
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@bridgeburn ; Can Xanax cause hair loss if I am already suffering from male pattern baldness?
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I think you are somewhat naive to think just 25mg would be enough, you’d need a much higher dose than that. When I was considering switching to Bica I’d read nothing but bad things about it’s efficacy and so ultimately decided that I would be better off staying on CPA. spironolactone is pretty sh*t aswell in my experience.
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Do you take CPA 50 mg every day? In your experience, from which dosage CPA can see effect?
Incorrect. 25MG is enough, it builds up in your body overtime similar to dutasteride. It doesn't matter if you take 50MG/day or 25MG/day, it still builds up in your body in the long-term. What bad information have you read?
Not true, Bicalutamide binds itself to the androgen receptors and it goes inside the cell, but unlike androgens that have coactivator transcription, it has corepressor transcription, and it can have a huge benefit when treating hair loss. When it comes to mutant prostate cancer cells, they somehow manage to get coactivator transcription through anything that brings the receptors inside. Thus, certain prostate cancer cells become bicalutamide resistant.
When using Dutasteride, Spironolactone, or Cyproterone Acetate, these just lower your androgen levels without blocking the receptor sites (Cyproterone does a decent job at blocking receptors). So Reflex Hyperandrogenicity can still occur.
25mg Bicalutamide should be enough to completely block hair loss for someone with <250ng/dl of testosterone. 50mg Bicalutamide for someone with <500ng/dl testosterone.
"Accordingly, a study comparing the efficacy of 50 mg/day bicalutamide versus 300 mg/day CPA in preventing the PSA flare at the start of GnRH agonist therapy in men with prostate cancer found that the two regimens were equivalently effective."
50mg Bicalutamide=300mg CPA in terms of reduction of the prostate size
50mg Bicalutamide has been reported to have the same antiandrogenic effect as 130mg spironolactone per day as they both have the same chance of gynecomastia (38%)
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Yeah, I used bica orally in 2018, but got a heart problem (arrhythmia I think).
I also used tamoxifen and duta, dualgen 5%... and got arrhythmia, when I ate 1 bica tablet. When I skipped a day, the heart problem was gone. I got mini-breasts and panic attacks (maybe because of tamoxifen and bica).So now I take Escitalopram and Phenazepam to treat my depression.
I gave up the idea of treating baldness and went to a psychotherapist, lol.
Oh... That's scary... I hope I don't get that yikes
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This is a very rare side effect. You'll notice it immediately after 1 tablet if it shows up. I know a boy who takes 75 mg bica plus 0.5 mg duta (plus minoxidil 5%) and got his hair back. He didn't have any problems except mini-breasts. I envied him and decided to try too, but 25-50 mg bica. I used bica for 1 month and duta for 4 months.
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through translator
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you had to add estradiol to your regimen if it wasn’t and if it was then it was necessary to increase the dose