Exploring The Hormonal Route. Hair=life.

[JaneyElizabeth]

In HRT for feminization and hair loss, do half-lives matter? I have seen no evidence that they do except in the sense of exceeding adult female targets of estrogen continuously for several months.

 

[JaneyElizabeth]

More rapid feminization​

Progesterone competes for the 5-alpha reductase enzyme that converts T into DHT (18), the hormone that masculinizes skin and hair follicles. Thus, progesterone decreases the masculinizing effects of DHT on unwanted male-pattern hair. My impression is that the slowness of improvement to feminine in facial and head hair is likely why transgender women may seek higher doses of E/E2. In my clinical experience, feminization occurred more rapidly with E2 and antiandrogens plus progesterone than with E2 and antiandrogens alone. Obviously spironolactone or cyproterone acetate play major roles in feminization by acting as direct androgen receptor blockers (7)

 

[JaneyElizabeth]

Oestrogen and anti-androgen therapy for transgender women

Transgender women experience lifelong gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. They often seek hormone therapy, with or without surgery, to improve their gender dysphoria and to better align ...

www.ncbi.nlm.nih.gov

]

There's a nice body diagram of all relevant changes including hair loss.

 

[JaneyElizabeth]

So yeah, I spend all day reading HRT articles but bang, check this out as to why AA's are often unnecessary and unsafe but again, you guys get freaked out by the letters E-S-T-R-O-G-E-N. None of that for me, gimme Bica, gimme spironolactone, gimme CPA.

The health risks attributed to estradiol doses high enough to suppress androgens have not been found in the parenteral or transdermal application of bioidentical estradiol. Thus it is unclear why those estradiol doses should be kept low in order to make the addition of androgen antagonists like CPA or spironolactone necessary.

Antiandrogens or estradiol treatments or both during hormone replacement therapy in transitioning transgender women

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:The objective of this proposed systematic review and meta‐analysis is to assess the efficacy and safety of hormone replacement therapy with antiandrogens or ...

www.ncbi.nlm.nih.gov

 

[JaneyElizabeth]

An important issue for many transgender women is breast development. But despite its importance, only a few low-quality studies have been done to investigate the effect of cross-sex hormone therapy on this outcome.39 Breast development starts within 2–3 months after initiation of combined oestrogen and anti-androgen treatment, and takes up to 2 years to complete. In a longitudinal study by Meyer and colleagues,34 breast hemi-circumference increased by 14 cm after 3 years of oestrogen therapy. The response to oestrogen can vary from individual to individual. Up to two-thirds of transgender women are unsatisfied with their breast development and apply for breast augmentation surgery .40 No evidence exists that the addition of progesterone improves breast development.39 Cross-sex hormone treatment has also been reported to lead to softening of the skin and feminine hair growth, but systematic studies have not been done.35,41

Oestrogen and anti-androgen therapy for transgender women

Transgender women experience lifelong gender dysphoria due to a gender assignment at birth that is incongruent with their gender identity. They often seek hormone therapy, with or without surgery, to improve their gender dysphoria and to better align ...

www.ncbi.nlm.nih.gov

 

[JaneyElizabeth]

Osteoporosis​

Cross-sex hormone treatment with oestrogens should be protective of bone density, since oestrogens are the major sex steroid hormone that prevents bone loss in both men and women.55 Low bone density is common after gonadectomy if oestrogen is not prescribed at adequate doses to prevent oestrogen concentrations from dropping into a menopausal range

 

[JaneyElizabeth]

Prostate cancer​

Since castration—either surgical or medical—is the primary treatment in prostate cancer, it might be expected that the incidence of prostate cancer is low in transgender women. Indeed, reports of prostate cancer have been limited to a few case reports.82 In a review of more than 1000 transgender women followed up by the Amsterdam clinic, only one case of prostate cancer was discovered.83 On the basis of the low overall prevalence of prostate cancer, these authors suggest screening for prostate cancer only after age 50 years.

 

[JaneyElizabeth]

Cross-sex hormone treatment affects secondary sex characteristics of transgender women, making them more feminine in appearance; however, it has little effect on the primary sex organs except to cause some testicular atrophy.6 Therefore, many transgender women will seek gender reaffirming surgeries to remove the testes and to create a neovagina.84 Breast development under cross-sex hormone treatment can often be unsatisfactory and thus many transgender women might choose to have breast augmentation surgery.85 In transgender women who initiate cross-sex hormone treatment after puberty, secondary male sex characteristics might require surgery such as chondrolaryngoplasty (the so-called tracheal shave) for a prominent larynx or facial feminisation for frontal bossing.86,87 Laryngoplasty can also be done to change the pitch of the voice.88 Before laryngoplasty, transgender women can benefit from undergoing voice assessment, conditioning, and therapy by a voice and communication professional.89

 

[JaneyElizabeth]

The Effects of Topically Applied Hormones on Growth, Pigmentation and Keratinization of the Nipple and Areola



THEFECTSOFTOPICALYAPLIEDHORMONESONGROWTH, PIGMENTATIONANDKERATINIZATIONOFTHENIPLE ANDAREOLA





CLAYTONE.WHELER,M.D.*,EDWARDP.CAWLEY,M.D.*ANDARTHURC. CURTIS, M.D.t





Topicalaplicationofanalcoholicadrenalextractwasfoundtoproduce unilateralgrowthandpigmentationoftheareolasandniplesofcastratedmale guineapigsinthecourseofapreviousexperiment.Thisobservationwasa stimulustodeterminewhichofotheravailablehormonesmighthaveanefect whenapliedlocaly.Thepresentcomunicationdescribestheresultsofexperi- mentalobservationsalongthisline.





Previousinvestigators(1—8)haveshownthatcertainestrogenicsubstances (estrone,estradiol,andstilbestrol)whenapliedtopicalyinsmalamountsto





thenipleandareolaofmice,guineapigs,rabits,monkeysandman,produced unilateralgrowthoftheniple,increasedpigmentationofthenipleandareola,





andgrowthoftheunderlyingmamarygland.Whenlargertopicaldosesof thesehormoneswereused,bilateralchangeswereobserved,indicatingpercu- taneousabsorptionandsystemicor"hematogenous"efectofthehormones.In adition,hormonesofadrena'andtesticularorigininaqueoussolutionswere





recorded(8)ascausingunilateralniplegrowthofminordegre.

 

[Ephemeral-Kitten]

So my choice to do this is illusory? Maybe if I separate out preference of a partner's gender from that of my gender. I am not attracted to men's faces or the way they look but at least half or more are attracted to men so that to me is sort of a basic divide that makes me feel non-binary and I have no dead name; I use both. I always disliked being male more than I pined for female organs although I would prefer them. I have had a lot of therapy, hundreds of visits and I still haven't figured all of this out. I do like having guys be attracted to me.

Treating androgen poisoning is something I will always support. I'm just saying gender dysphoria is not something that is "late onset", so either you have had dysphoria for longer than you realize (but repressed it), or you have something other than typical gender dysphoria. Whatever the reason though, morphological autonomy should be maintained.

Sexuality also has nothing to do with it. So I wouldn't say that makes you non-binary by itself.

Part of my ethic is literally not wanting to possess something that can be used as a weapon in assault.

I'm very pro gun rights/gun ownership. The fact of the matter though, is that male biology tends to increase violent tendencies, more so than socialization. It is hormonal. Liberals don't like to acknowledge that fact because it goes against their tabula rasa ideology.

 

[JaneyElizabeth]

I am al left-wing libertarian.

 

[Ephemeral-Kitten]

I am al left-wing libertarian.

I see, I am Marxist-Leninist, so authoritarian left.

 

[Ephemeral-Kitten]

Prostate cancer​

Since castration—either surgical or medical—is the primary treatment in prostate cancer, it might be expected that the incidence of prostate cancer is low in transgender women. Indeed, reports of prostate cancer have been limited to a few case reports.82 In a review of more than 1000 transgender women followed up by the Amsterdam clinic, only one case of prostate cancer was discovered.83 On the basis of the low overall prevalence of prostate cancer, these authors suggest screening for prostate cancer only after age 50 years.

Yeah, trans women have prostate cancer risks way lower than untreated amabs and breast cancer risks somewhat lower than afab women. Overall a net benefit to health in terms of cancer risk I would say.

 

[JaneyElizabeth]

I see, I am Marxist-Leninist, so authoritarian left.

I grew up listening to Radio Habana Cuba wearing a beret and "Che" was my nickname after I read "Guerrilla Warfare.".

 

[JaneyElizabeth]

Yeah, trans women have prostate cancer risks way lower than untreated amabs and breast cancer risks somewhat lower than afab women. Overall a net benefit to health in terms of cancer risk I would say.

My effects in terms of rejuvenation of everything have been astounding and thrilling. I tout HRT as life-saver and beauty technique not to mention the exquisite.

 

[Ephemeral-Kitten]

So yeah, I spend all day reading HRT articles but bang, check this out as to why AA's are often unnecessary and unsafe but again, you guys get freaked out by the letters E-S-T-R-O-G-E-N. None of that for me, gimme Bica, gimme spironolactone, gimme CPA.

The health risks attributed to estradiol doses high enough to suppress androgens have not been found in the parenteral or transdermal application of bioidentical estradiol. Thus it is unclear why those estradiol doses should be kept low in order to make the addition of androgen antagonists like CPA or spironolactone necessary.

Antiandrogens or estradiol treatments or both during hormone replacement therapy in transitioning transgender women

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:The objective of this proposed systematic review and meta‐analysis is to assess the efficacy and safety of hormone replacement therapy with antiandrogens or ...

www.ncbi.nlm.nih.gov

This is true, however, I will add a caveat that female hormone levels alone is not necessarily enough to regrow temple hair. For that I think sub physiological levels of androgen transcription is needed due to how sensitive that area is to androgens. (You can also see this in the way lots of cis women have receded temples despite having "normal" range testosterone and estradiol levels, simply due to being prone to hair loss and having the receptor sensitivity there.)

 

[JaneyElizabeth]

This is true, however, I will add a caveat that female hormone levels alone is not necessarily enough to regrow temple hair. For that I think sub physiological levels of androgen transcription is needed due to how sensitive that area is to androgens. (You can also see this in the way lots of cis women have receded temples despite having "normal" range testosterone and estradiol levels, simply due to being prone to hair loss and having the receptor sensitivity there.)

I am far north of 400 pg/ml. I love the mind-set.

 

[Ephemeral-Kitten]

I am far north of 400 pg/ml. I love the mind-set.

That is good for reducing LH, so all of your androgens should come from the adrenals at that point. However, with unblocked receptors that is still enough androgens to do harm. The high E2 also helps with that a bit though as it spikes SHBG and binds the free T/DHT. But a receptor antagonist may still be indicated for full results.

You're on dutasteride though as I recall, which will help make up for not blocking the AR a bit.

 

[SnortingFinasteride]

– I am aggressively balding and really want my hair
– Take Bicalutamide
– Will my libido decrease?
– Dude you said you want your hair
– Only "male" procedures!

I will never understand these people. The Russian balding community consists entirely of such people, on this forum the situation is better
First, people whine that they do not want to become bald, and then they scream that they cannot afford a decrease in libido. Cowardly fools will go bald and I don't feel sorry for them

With all due respect, Bica is not a guarantee to regrow hair, not even Estrogen is a guarantee, nothing is a guarantee.




People need to weight the pros and cons of each treatment, and as for the case of Bica, it is not as much a "libido" issue as it is an 80% chance of gyno. So i can totally understand the "Err" on the Bica option. Messing with Androgen Receptors has always been a fear of mine, since we don't know many things about the matter to begin with..




You need to acknowledge that here we are speaking of prostate cancer drugs with liver failure as a side effect, Estradiol, birth controls, progesterone, medications that can cause brain tumours (a.k.a CPA) ect... it is not a "cowardly" act to have second thoughts.

 

[Almas]

With all due respect, Bica is not a guarantee to regrow hair, not even Estrogen is a guarantee, nothing is a guarantee.




People need to weight the pros and cons of each treatment, and as for the case of Bica, it is not as much a "libido" issue as it is an 80% chance of gyno. So i can totally understand the "Err" on the Bica option. Messing with Androgen Receptors has always been a fear of mine, since we don't know many things about the matter to begin with..




You need to acknowledge that here we are speaking of prostate cancer drugs with liver failure as a side effect, Estradiol, birth controls, progesterone, medications that can cause brain tumours (a.k.a CPA) ect... it is not a "cowardly" act to have second thoughts.

If a person says that he is very worried about baldness, and then whines that he is worried about a decrease in libido or something else, hair loss does not bother him that much
First they say how bad it is for them to go bald. And then they refuse treatment because of some trifles. You can live with reduced libido, gynecomastia is a solvable problem. Baldness + cowardice is a sentence
Either compromise or don't whine and watch your head turn into an ***