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You need progesterone to grow temples, progesterone grows temples
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Damn I just saw pictures of myself when I was 13... I had temples. Literally TEMPLES, female hairline. I can't believe my hairline changed in 4 years to a NW2. Rip
Might not be able to recover from this without transplants. Not even E would guarantee temple regrowth. I will soon start 100mg Bicalutamide, I still am thinking about using it with a SERM (Raloxifene 80/120mg), but I don't know if it is a good idea, as we discussed earlier.
Might not be able to recover from this without transplants. Not even E would guarantee temple regrowth. I will soon start 100mg Bicalutamide, I still am thinking about using it with a SERM (Raloxifene 80/120mg), but I don't know if it is a good idea, as we discussed earlier.
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Can anyone answer me if E3 in high serum amounts is able to inhibit aromatase?
This feedback from estrone, estradiol and estriol is strange
In what sense?
E3 is the end of the hormonal conversion cycle, but it is "weak" compared to E1 and E2
If a patient is being treated with E3, if the case reaches supraphysiological levels, would we inhibit T cover in E2?
Since it is E2 that becomes E3.
I think E3 is not able to inhibit the HPT AXIS, but is it able to inhibit conversion from T to E2?
I think that maybe the body imagines that high levels of E3 means high levels of E2 .
Someone know how does it work ?
This feedback from estrone, estradiol and estriol is strange
In what sense?
E3 is the end of the hormonal conversion cycle, but it is "weak" compared to E1 and E2
If a patient is being treated with E3, if the case reaches supraphysiological levels, would we inhibit T cover in E2?
Since it is E2 that becomes E3.
I think E3 is not able to inhibit the HPT AXIS, but is it able to inhibit conversion from T to E2?
I think that maybe the body imagines that high levels of E3 means high levels of E2 .
Someone know how does it work ?
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Not much at all, if i didn't had hair i'd look the same when i started. Except i have less acne and thinner skin.
yar's big science moment
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No one has conducted them,but this is logical since progesterone is produced in both sexes and protects against baldness.When women have problems with the cycle, that is, a lack of progesterone in the luteal phase ,hirsutism, alopecia, begins.In the same way, men produce progesterone, which protects men from baldness,and estrogen, it only prolongs the anagen phase of hair growth!Take progesterone!
Gergely those are pretty impressive results. Your hairline dropped a few cm and the overall quality of the hair just looks denser and more healthy. What was your regimen in those photos? and how long were you on it?
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I have never seen any articles on progesterone for hair loss. MtF's use it to attempt to reach Tanner Five in breast size and we aren't sure that it even does that. I cycle 300 mg ten days a month of P4 and also synthetic medroxyprogesterone acetate @10 mg daily. I don't see it doing as much for hair as estradiol but we would need people only using P4 to reach any conclusions via testing.
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Of course there were, I put it up, it's higher up the branch
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Would be awesome if member of this site would do a file where they upload their hair while on treatment every month or so every time change is cosmetically noticeable. Like @Itsnoahkennedy did.
Hmm could be an assumption, especially becauses E3 antagonizes E2 when it's not present in a continuous fashion.
->https://en.wikipedia.org/wiki/Estriol_(medication)
"Although estriol is an estrogen, it has also been reported to have mixed agonist–antagonist or partial agonist activity at the ERs. On its own, it is said to be weakly estrogenic, but in the presence of estradiol, it has been found to be antiestrogenic. However, this is again due to the fact that estriol is a "short-acting" estrogen. If estriol is present continuously with estradiol, it shows no antagonism of estradiol. The co-administration of estriol with estradiol has been found not to influence the effects of the latter in women, including neither enhancing nor antagonizing the effects of estradiol."
From studies:
"Short acting estrogens would not be antagonists if they were present in a continuous fashion which would result in constant or long term occupancy of the estrogen receptor. Pollard and Martin showed that frequent administration of DMS stimulated full estrogenic responses in the mouse vagina. They suggested that this effect was the result of continuous occupancy of receptors, We confirmed these observations in the rat by injecting estriol every 3 h for 15 h and observing full estrogenic stimulation of the uterus. Likewise, Martin et al. obtained similar results with the mouse uterus. These results demonstrate that short acting estrogens are neither ineffectual nor antagonistic when present in a continuous or chronic fashion."
"Whereas estradiol remains bound to the ER for 6 to 24 hours with a single short-acting injection, estriol dissociates from the receptor much more rapidly and stays bound for only 1 to 6 hours. As a result, estriol can only induce estrogenic effects which require short-term interaction with the ERs. Induction of endometrial mitoses requires the ligand to remain bound for at least 9 to 12 hours, and this is thought to be responsible for the lack of endometrial proliferation with estriol in many studies. If estriol is delivered more continuously than a single administration per day however, for instance if it is given as a subcutaneous pellet, as a depot injection, or in multiple doses two or three times per day, this results in more sustained exposure to estriol and full estrogenic responses equivalent to those of estradiol occur."
"Unlike oestrone, oestriol cannot be converted to oestradiol. It acts as a weak oestrogen, because the duration of nuclear receptor binding is relatively short. It therefore has no proliferative effect on the endometrium when 2 or 4 mg are ingested. However, where the presence of oestriol in the target cells at sufficient concentrations is prolonged, e.g., when 4 mg is taken twice, or 2 mg 3 times per day, or high doses are ingested (8 mg or more daily), the hormonal action of oestriol is enhanced."
"When oestriol is administered together with oestradiol it does not exert any demonstrable biological effect, neither enhancing nor antagonizing the action of oestradiol"
I guess that there won't be a problem if it's taken alone and not surpass the normal levels, because is acting like estrogen, weak, but estrogen. Although, when it's come to E2, they should be taken together, like the researches mentioning. Otherwise, I think it would/will be bad for hair in general. (though->The co-administration of estriol with estradiol has been found not to influence the effects of the latter in women, including neither enhancing nor antagonizing the effects of estradiol---So, I can't truly tell)
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I do it on average every two weeks and there has been a clear and unrelenting improvement in my situation the last 18 months. My crown has completely filled and hairline continues coming down. I also have posted on my blog at different junctures where I know what I was on. The younger guys are obviously not going to have nearly as impressive turnarounds as @bridgeburn and I since most of them are distinctly not "bald" albeit balding. The man in the street might not notice that Gergely's hairline has been restored but when you see before, during and after pics of XY's with bald heads that presents visual drama along with confirmation of results.
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This is helpful. My feeling is that for most XY's, estriol is likely to be only mildly feminizing. I doubt that it could offset breast growth if used in quantities large enough to theoretically antagonize the stronger estrogens (E2 and E1). To the body, estriol is likely to be deemed to be "estrogen" and I think that it is more likely to initiate breast growth than to halt it. The other thing is that generally, these attempts to distinguish between receptors and general strength go nowhere in terms of inducing one desired effect vs. others not wanted with the exception of SERMS which present other issues. To wit: it is not easy to only feminize one body area while leaving the others "masculine".
You cannot stay on estradiol all the time, I see it only as a short-term therapy for regrowth. I don’t know how long it should take to improve the hair, but if you use it too long, your testicles may stop producing T. And that’s forever, like castration.
I really hope that I don't have to touch E
I really hope that I don't have to touch E
It would be good to know how long it takes at least E to harm the testicles. And how long does it take E to restore your follicles. E is necessary for regrowth, it would be good for bald people to get regrowth like Bridgeburn on Bica + E, and then maintain the result on Bica. Minoxidil does not cure Androgenetic Alopecia, but hides its progression
However, I am scared to think about it. What I said implies that we need to go to the hormonal level of the woman for about six months, and then go back to the male levels. I'm not sure if it's painless. And such radical ways disturb me. However, we always have to take risks for the sake of beauty, so this is not a strong obstacle.
However, I am scared to think about it. What I said implies that we need to go to the hormonal level of the woman for about six months, and then go back to the male levels. I'm not sure if it's painless. And such radical ways disturb me. However, we always have to take risks for the sake of beauty, so this is not a strong obstacle.