Buddy, E is toxic for testicles. It will shut down your HPG/HPT axis, you might not recover well and will need to do TRT or/and HCG to recover somehow at the worst case.It would be good to know how long it takes at least E to harm the testicles. And how long does it take E to restore your follicles. E is necessary for regrowth, it would be good for bald people to get regrowth like Bridgeburn on Bica + E, and then maintain the result on Bica. Minoxidil does not cure Androgenetic Alopecia, but hides its progression
However, I am scared to think about it. What I said implies that we need to go to the hormonal level of the woman for about six months, and then go back to the male levels. I'm not sure if it's painless. And such radical ways disturb me. However, we always have to take risks for the sake of beauty, so this is not a strong obstacle.
Yes, it is dangerous if you are not a trance. Therefore, we hope for Bicalutamide.Buddy, E is toxic for testicles. It will shut down your HPG/HPT axis, you might not recover well and will need to do TRT or/and HCG to recover somehow at the worst case.
Hmm could be an assumption, especially becauses E3 antagonizes E2 when it's not present in a continuous fashion.
->https://en.wikipedia.org/wiki/Estriol_(medication)
"Although estriol is an estrogen, it has also been reported to have mixed agonist–antagonist or partial agonist activity at the ERs. On its own, it is said to be weakly estrogenic, but in the presence of estradiol, it has been found to be antiestrogenic. However, this is again due to the fact that estriol is a "short-acting" estrogen. If estriol is present continuously with estradiol, it shows no antagonism of estradiol. The co-administration of estriol with estradiol has been found not to influence the effects of the latter in women, including neither enhancing nor antagonizing the effects of estradiol."
From studies:
"Short acting estrogens would not be antagonists if they were present in a continuous fashion which would result in constant or long term occupancy of the estrogen receptor. Pollard and Martin showed that frequent administration of DMS stimulated full estrogenic responses in the mouse vagina. They suggested that this effect was the result of continuous occupancy of receptors, We confirmed these observations in the rat by injecting estriol every 3 h for 15 h and observing full estrogenic stimulation of the uterus. Likewise, Martin et al. obtained similar results with the mouse uterus. These results demonstrate that short acting estrogens are neither ineffectual nor antagonistic when present in a continuous or chronic fashion."
"Whereas estradiol remains bound to the ER for 6 to 24 hours with a single short-acting injection, estriol dissociates from the receptor much more rapidly and stays bound for only 1 to 6 hours. As a result, estriol can only induce estrogenic effects which require short-term interaction with the ERs. Induction of endometrial mitoses requires the ligand to remain bound for at least 9 to 12 hours, and this is thought to be responsible for the lack of endometrial proliferation with estriol in many studies. If estriol is delivered more continuously than a single administration per day however, for instance if it is given as a subcutaneous pellet, as a depot injection, or in multiple doses two or three times per day, this results in more sustained exposure to estriol and full estrogenic responses equivalent to those of estradiol occur."
"Unlike oestrone, oestriol cannot be converted to oestradiol. It acts as a weak oestrogen, because the duration of nuclear receptor binding is relatively short. It therefore has no proliferative effect on the endometrium when 2 or 4 mg are ingested. However, where the presence of oestriol in the target cells at sufficient concentrations is prolonged, e.g., when 4 mg is taken twice, or 2 mg 3 times per day, or high doses are ingested (8 mg or more daily), the hormonal action of oestriol is enhanced."
"When oestriol is administered together with oestradiol it does not exert any demonstrable biological effect, neither enhancing nor antagonizing the action of oestradiol"
I guess that there won't be a problem if it's taken alone and not surpass the normal levels, because is acting like estrogen, weak, but estrogen. Although, when it's come to E2, they should be taken together, like the researches mentioning. Otherwise, I think it would/will be bad for hair in general. (though->The co-administration of estriol with estradiol has been found not to influence the effects of the latter in women, including neither enhancing nor antagonizing the effects of estradiol---So, I can't truly tell)
Estrogen and anti-androgen since 2019 december, if i didn't had a constant shed i think my results would be perfect.Gergely those are pretty impressive results. Your hairline dropped a few cm and the overall quality of the hair just looks denser and more healthy. What was your regimen in those photos? and how long were you on it?
what dosage was your estrogen and what what your dosage of AA and which one were you taking?Estrogen and anti-androgen since 2019 december, if i didn't had a constant shed i think my results would be perfect.
The general mtf hrt, i start with 2 mg sublingual E2 and up from there. 100mg spironolactone to 200mg, switched to bica 50mg and incresed E2 to 4mg graduali uped my dosage to 8mg at one point but i had to cut it because the supply shortage. Tryed 100mg progesterone for a while +oestrogel.what dosage was your estrogen and what what your dosage of AA and which one were you taking?
Do you have hair right?Take progesterone at night and you will be happy, do not take any finasterides or bic,.Take just progesterone and you will save your hair!The body needs progesterone,you can add estrogen for the overall effect!
Will progesterone feminize you on its own?Take progesterone at night and you will be happy, do not take any finasterides or bic,.Take just progesterone and you will save your hair!The body needs progesterone,you can add estrogen for the overall effect!
I don’t think so. He got a full regrowth, there is no point in making the regime stronger. On the contrary, it made sense to reduce the dosage to 75-100mg. 150mg is too muchDo we know if DHTcel used something more than just 150mg Bicalutamide and 0,5mg Dutasteride?
Bicalutamide is the only medicine. We can wait for developments in the field of hair transplant for those whose follicles have died, but my follicles are alive, so I want to keep Norwood 0. I need hair thickening, Bicalutamide can give it.Will we be able to sustain till the "CURE" comes out!?
My god thank you!!! Cant wait collecting all these studies and spamming my Doctor. He can't deny lmaoDihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia - PubMed
Androgenic alopecia (Androgenetic Alopecia), also known as male pattern baldness, is one of the most common hair loss diseases worldwide. The main treatments of Androgenetic Alopecia include hair transplant surgery, oral medicines, and LDL laser irradiation, although no treatment to date can fully cure this disease. Animal models...pubmed.ncbi.nlm.nih.gov
Bicalutamide Treats Androgenetic Alopecia in Mice