Exploring The Hormonal Route. Hair=life.

[Pls_NW-1]

Hello everyone. I have a special intolerance to finasteride and dutasteride. many say reductase inhibitors are essential. can i take estradiol cyproterone or spironolactone. will that be enough?

Dont touch cyproterone. I dont understand why people bother with that. Dont take it if you take dutasteride. They both interact together in a bad way. And especially dont take a NSAA with a SAA.

 

[Pls_NW-1]

Can just someone explain me how I work as a full male when my Testosterone is only 300 ng/dl?! Lol

This is really scary lol

 

[DHTHUNTER]

Please test your DHEA-S, Androsterone/Pregnane-...-dione

You might be a DHT mutant and your body tanks all the androgens through the alternate pathway, the adrenal one. Like mine dose.

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my DHEA S is very high. 2 times more. I need spironolactone and estradiol. I can’t take dutasteride. is it possible to do without dutasteride

 

[Pls_NW-1]

my DHEA S is very high. 2 times more. I need spironolactone and estradiol. I can’t take dutasteride. is it possible to do without dutasteride

My DHEA-S is as well very high, 1,5 times more than normal, as well.

The only thing which can help eleminating adrenal androgen precursors is supplementing Resveratrol (500-1000mg).

The other thing is Abiraterone Acetate, a drug stoping the ACTH signaling to produce DHEA-S through the adrenal gland, used for resistant prostate cancer. This is too harsh for us.

Bicalutamide is a great option, but yes, Spironolactone as well, because it essentially blocks Androsterone, urinating it off your body. Androsterone is essential I think for creating alternate DHT in certain tissues, like skin/follicle. (See graphic is posted earlier.)

Why can't you take Dutasteride?

 

[DHTHUNTER]

My DHEA-S is as well very high, 1,5 times more than normal, as well.

The only thing which can help eleminating adrenal androgen precursors is supplementing Resveratrol (500-1000mg).

The other thing is Abiraterone Acetate, a drug stoping the ACTH signaling to produce DHEA-S through the adrenal gland, used for resistant prostate cancer. This is too harsh for us.

Bicalutamide is a great option, but yes, Spironolactone as well, because it essentially blocks Androsterone, urinating it off your body. Androsterone is essential I think for creating alternate DHT in certain tissues, like skin/follicle. (See graphic is posted earlier.)

Why can't you take Dutasteride?

I have a fog in my head from Avodart. like a drunk. I become very weak and overwhelmed. rasveratrol is very expensive. Do you think a regular dietary supplement can suppress the adrenal glands better than spironolactone?

 

[JaneyElizabeth]

I have a fog in my head from Avodart. like a drunk. I become very weak and overwhelmed. rasveratrol is very expensive. Do you think a regular dietary supplement can suppress the adrenal glands better than spironolactone?

But how is blocking T with spironolactone going to make you feel less drunk? Most people will tell you that spironolactone has by far the most effect on strength and conditioning. Duta isn't even close or in the ballpark and I have used both extensively. spironolactone is associated with fatigue, brain fog, depletion of Nacl, loss of strength and I could go on and on, excessive sweating is another side and I had all of them and I never had a side with any other medication of any kind my entire life. Estrogen pales in sides to spironolactone.

 

[Pls_NW-1]

I have a fog in my head from Avodart. like a drunk. I become very weak and overwhelmed. rasveratrol is very expensive. Do you think a regular dietary supplement can suppress the adrenal glands better than spironolactone?

I would check if my adrenal gland works well firstly. I only can recommend Resveratrol, it's really healthy, eleminates (free) radicals, reduces oxidative stress, promotes better oxygen supply and eleminates (adrenal) androgen precursors by -50%.

Spironolactone is very great as it is a SAA and affects negativly the HPTA axis, but I am not sure if it's great for a cis male tbh. Tho the AA properties are very weak.

Thats a shame that avodart does not work.

Diet and stressless life helps a lot with adrenal androgens. Especially diet, try no sugar, low calories etc/ low carb.... etc. and movement, walking in morning and night is really healthy.

 

[Pls_NW-1]

But how is blocking T with spironolactone going to make you feel less drunk? Most people will tell you that spironolactone has by far the most effect on strength and conditioning. Duta isn't even close or in the ballpark and I have used both extensively. spironolactone is associated with fatigue, brain fog, depletion of Nacl, loss of strength and I could go on and on, excessive sweating is another side and I had all of them and I never had a side with any other medication of any kind my entire life. Estrogen pales in sides to spironolactone.

I have to agree here.

 

[DHTHUNTER]

But how is blocking T with spironolactone going to make you feel less drunk? Most people will tell you that spironolactone has by far the most effect on strength and conditioning. Duta isn't even close or in the ballpark and I have used both extensively. spironolactone is associated with fatigue, brain fog, depletion of Nacl, loss of strength and I could go on and on, excessive sweating is another side and I had all of them and I never had a side with any other medication of any kind my entire life. Estrogen pales in sides to spironolactone.

do you use a lot of estrogen without AA? don't you take dutasteride too?

 

[JaneyElizabeth]

do you use a lot of estrogen without AA? don't you take dutasteride too?

I do although AA is a term of art in HRT. Technically reductase inhibitors are a type of anti-androgen but a selective type. I do use medroxyprogesterone acetate and progesterone which lower T but not like "AA's" do. The main three AA's are bicalutamide, CPA and spironolactone and they all work more so by blocking receptors than actually lowering T, especially bica and spironolactone. CPA is sort of in the middle between MPA/provera and bica and spironolactone in terms of how it works.

 

[Pls_NW-1]

I wouldn't clasify bicalutamide as a transgender drug, especially not in a monotherapy. Only if it is used in conjunction with Estorgen, then it is heavily feminizing and a real transgender drug.

 

[JaneyElizabeth]

I wouldn't clasify bicalutamide as a transgender drug, especially not in a monotherapy. Only if it is used in conjunction with Estorgen, then it is heavily feminizing and a real transgender drug.

Well, we need terms that males feel comfortable with. We could call all of them prostate medications and I wish I had used that excuse with my family some times. But in general, anything that works for the treatment of prostate cancer tends to promote scalp hair growth and diminishes body hair growth.

 

[Pls_NW-1]

Well, we need terms that males feel comfortable with. We could call all of them prostate medications and I wish I had used that excuse with my family some times. But in general, anything that works for the treatment of prostate cancer tends to promote scalp hair growth and diminishes body hair growth.

Bicalutamide does not cause heavy feminization. I just don't buy it. The only thing it can cause is severe gynecomastia and estrogenic skin.

 

[DHTHUNTER]

I would gladly take resveratrol if it could work like AA. But it seems to me that this will not be enough

 

[JaneyElizabeth]

Bicalutamide does not cause heavy feminization. I just don't buy it. The only thing it can cause is severe gynecomastia and estrogenic skin.

I am agnostic on it. I don't plan on using any of the three main AA's. They all have sides and they all have liver effects unlike parenteral estrogen. I do know that the Dr. Will Powers folks seem to proclaim that more bica means more breasts....

 

[Pls_NW-1]

I would gladly take resveratrol if it could work like AA. But it seems to me that this will not be enough

Yes, it's just a supportive role.

 

[JaneyElizabeth]

By the way, Pls and I are just about the fastest typists on the planet....

 

[JaneyElizabeth]

By the way, Pls and I are just about the fastest typists on the planet....

I am even missing three keys, lol but I have learned just to press those even harder....

 

[DHTHUNTER]

the fact is that MTF do not take Avodart and Finasteride at all. they accept AA and E. So there is no point in avodart. I am not mtf, I just grow hair

 

[Pls_NW-1]

the fact is that MTF do not take Avodart and Finasteride at all. they accept AA and E. So there is no point in avodart. I am not mtf, I just grow hair

MtF take Avodart. It's a must lol