Jacob
Senior Member
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If one orders the PQQ from Amazon...you may see a paper inside with a code for 5% off your next purchase directly from Supervits. Keep that in mind when figuring out the prices...how much you order this first time via Amazon...etc.
Here's a good read from Dr. Murray on CoQ10, ubiquinol..etc.
http://www.doctormurray.com/2011/06/coenzyme-q10-uses-forms-and-dosage-recommendations/
Get's into the nano versions etc a bit:
Here's a good read from Dr. Murray on CoQ10, ubiquinol..etc.
http://www.doctormurray.com/2011/06/coenzyme-q10-uses-forms-and-dosage-recommendations/
Is it true that ubiquinol is 8 times better absorbed than ubiquinone?
No, this marketing statement is taking data out of context. It involved comparing the absorption of 300 mg of ubiquinol in the aforementioned absorption study with blood levels achieved in studies in Parkinson’s disease were dosages of 2,400 mg of ubiquinone were given along with 1,200 IU of vitamin E. The problem with this comparison is that high dosage vitamin E interferes with CoQ10 absorption and when dosages of ubiquinone exceed 300 mg the percentage of CoQ10 absorbed declines significantly. Plasma CoQ10 levels at a dosage of 2,400 mg per day are not significantly greater than a 600 mg per day dosage. So, a more accurate approximation is that ubiquinol is only slightly better absorbed compared to CoQ10 in soft gel capsules emulsified with rice bran oil at dosages of 100 mg per day and about two times better absorbed compared at 300 mg per day as shown in the tables above.
Get's into the nano versions etc a bit:
While many have jumped on the ubiquinol bandwagon, it is important to point out that ubiquinone has an extensive history of successful use, particularly in oil-based soft-gelatin capsules. Furthermore, several technologies are now used to enhance the bioavailability of ubiquinone such as particle size reduction (nanonization) and solubility enhancement via use of emulsifying agents, carriers, and self-emulsifying systems.14 For example, complexing ubiquinone to a soy peptide (BioQ10 SA) has shown exceptional bioavailability as the soy peptide emulsifies the CoQ10 and helps usher it into the blood stream.15 Given the excellent absorption of this form of ubiquinone, the advantage of ubiquinol over regular ubiquinone appears to have more to do with its improved solubility than because it is in the ubiquinol form.