It doesn't matter how long you've been bald you can regrow hair. It just takes patience. I got on dutasteride around Thanksgiving. I only got really serious about my treatment around 5/2020 when I started adding more experimental treatments.
View attachment 144898 View attachment 144900 View attachment 144901 View attachment 144899 View attachment 144896 View attachment 144897 8-10-2020
View attachment 145671
9-12-2020
Here's a detailed breakdown of what I do for everyone asking about doses and scheduling. I make rotating batches of 40ml which lasts for 10 days. I apply 2ml morning and evening. Each batch consists of the following:
WAY-316606 100mg WAY is always added first and warmed to 50°C in order to fully dissolve
Dutasteride 20mg
RU58841 1000mg
Estriol 400mg
CHIR99021 10mg
Dinoprost 20mg
Bisindolylmaleimide I CAS 133052-90-1 20mg This is only used in the first batch when it is time to microneedle. I microneedle 24 hours after my first application of this batch.
SW033291 20mg
PGE2 20mg PGE2 is always added last to minimize degradation
It's very important to keep the solution in a tightly sealed container and protected from light. It's ok to store it at room temp. You can store it in the refrigerator too, but it may precipitate some. If it does you'll have to shake it until it dissolves.
The vehicle:
DMSO 4ml : 200 or 195 Ethanol 8ml : Benzyl Alcohol 2ml: PG 24ml : Oleic Acid 2ml : Tween80 just a few drops to a quarter ml.
I make one batch like this and
microneedle 24 hours after I begin using this batch. IOW I microneedle immediately before or after applying my third batch with BIM-I. Then I make one batch without BIM I before repeating. If I'm being lazy I'll put off microneedling for another ten days and make two batches without BIM-I. Note: BIM-I mildly stains the scalp, but it washes off easily.
Per the latest Cotsarelis
patent I apply 2ml of SAG once a day on days 5-8 after wounding, using 1.5mg/ml. I've also tried adding SAG to my entire first batch. This seemed to work quite well, and it's easier to just add 20mg to the first batch rather than making a second solution for SAG. It's also easier on the scalp. The downside is this is riskier and obviously more costly.
To make 4 days worth of
SAG I use:
195 ethanol 2ml : PG 5.5ml : Oleic Acid .5ml : SAG 12mg.
That's it for the topicals, now the oral part of the regimen.
Eplerenone 50mg twice a day. I might increase this to 100mg twice a day, but always start lower
Oral Minoxidil 5mg twice a day
Dutasteride .5mg once a day
Rapamycin 7mg once a week
This is a visual of everything I do except for supplements and peptides.
View attachment 147904
Optimal
microneedling time will vary depending on the device used. I use a
Derminator2 with
12-needle cartridges on the fastest setting, which is 24hz. I never reuse cartridges.
Notes:
At the listed dosages the total cost for everything here is under $300/mo. when bought in bulk. I wasted a lot of money experimenting with different doses and compounds so you don't have to. Concentrations listed here should be sufficient, and you could probably even cut it down to 1ml twice a day to cut the cost in half.
You could also add 120mg of ASC-J9 to each batch for a concentration of .3%. This will degrade the AR in your scalp. The problem with this is ASC is very messy. Also it downregulates NF-kB, so it's not the ideal SARD. A better option would be UT-155, but the price I was quoted would be around 20 grand for a month's supply. Maybe a big group buy could bring it down to a reasonable price.
At some point I will replace CHIR99021 with
KY19382 at .05% concentration.
I'm probably going to add
TM30089 at .1% because SW increases
PGD2 in addition to PGE2 and PGF2a.
This is not a regimen for people who have cancer or other health problems like heart disease, liver or kidney problems, and it's not something to be on indefinitely. This is an aggressive way to get your hair back without feminization, and then maintain with dutasteride.
Some people may want to forego oral dutasteride and only use topical dutasteride, or vice versa. I can say that with this vehicle the absorption rate is high, and topical dutasteride having a long half-life will go systemic. Also, some people may get some sides with estriol at this dosage. In that case they can lower the dosage to 10mg/day where almost no one should get sides. If you're extra sensitive to AA therapy then you could eliminate dutasteride altogether and still likely get excellent results.
Edit:
A couple more before pictures. The shaved head is when I started treatment. The next one is grown out a couple months later in brighter light. Then two pics from the other day under neutral light and bright light, respectively. I took a month off treatment due to my travel schedule and some other factors. My scalp is healed and ready to begin needling again soon. It doesn't look like I lost any ground during the time off.
