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Scalp and forehead turn reddish for a couple of hours.
Hair Today Hair Tomorrow Hair Forever
- Thread starter pegasus2
- Start date
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This is spectacular. Can't believe I missed this until just now. Sadly this regimen is out of my reach logistically and financially.
Wow, was that previously slick bald in those temples?
@pegasus2
I'm a diffuse thinner who has been struggling to maintain on dutasteride since the start of my hair loss over 7 years. In your opinion what is the best thing I can add to my regime to help maintain that is not an androgen receptor blocker/antagonist reason being is I believe in the AR blocker and AR upregulation theory.
Note: I'm also a minoxidil non-responder.
I'm a diffuse thinner who has been struggling to maintain on dutasteride since the start of my hair loss over 7 years. In your opinion what is the best thing I can add to my regime to help maintain that is not an androgen receptor blocker/antagonist reason being is I believe in the AR blocker and AR upregulation theory.
Note: I'm also a minoxidil non-responder.
Estrogen downregulates the AR. I would recommend estriol and minoxidil sulphate, which works for non-responders.
Estriol orally or topically? How much would you recommend daily?
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Topical please. I've used from 40mg up to 100mg daily
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Do you have studies saying that estriol downregulates AR ?
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Autoregulation of estrogen and androgen receptor mRNAs and downregulation of androgen receptor mRNA by estrogen in primary cultures of lizard testis cells - PubMed
Steroid hormones regulate many developmental and physiological processes via specific receptors whose number can be up- or downregulated. The regulation of estrogen (ER) and androgen (AR) receptor mRNAs in primary cultures of lizard testis is described. The high degree of homology between the...
pubmed.ncbi.nlm.nih.gov
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That's for lizards tho, this doesnt necessarily translates to humans :/
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Unless you believe that it all started with Adam and Eve...
Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of spermatogenesis. Studies on reptile spermatogenesis are negligible hence this study will prove to be an important resource.
www.ncbi.nlm.nih.gov
Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of spermatogenesis. Studies on reptile spermatogenesis are negligible hence this study will prove to be an important resource.
Transcriptome Analysis of Spermatogenically Regressed, Recrudescent and Active Phase Testis of Seasonally Breeding Wall Lizards Hemidactylus flaviviridis - PMC
Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of ...
www.ncbi.nlm.nih.gov
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Unless you believe that it all started with Adam and Eve.
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I don't lmao, that's a low blowUnless you believe that it all started with Adam and Eve...
Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of spermatogenesis. Studies on reptile spermatogenesis are negligible hence this study will prove to be an important resource.
Transcriptome Analysis of Spermatogenically Regressed, Recrudescent and Active Phase Testis of Seasonally Breeding Wall Lizards Hemidactylus flaviviridis - PMC
Reptiles are phylogenically important group of organisms as mammals have evolved from them. Wall lizard testis exhibits clearly distinct morphology during various phases of a reproductive cycle making them an interesting model to study regulation of ...
Because again, stuff that happens in other animals wont necessarily translate to us humans. Cats are mammals like us, but they can't produce arachidonic acid, and they also die if they touch minoxidil. But they still are closer to us than reptiles. I ofc won't stop using estriol if it doesnt downregulate AR (it has a lot of other cool and useful effects for the skin and the hair), but i just wanted to have a good source of evidence I could point to if it did.
TLDR : If you have a study on humans, I would really appreciate that. Still, thanks for the info on lizards.
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Pegasus2 You had comented in october that you had taken a month off without treatment .... Are you currently with all initial protocol (Ru, dutas, estriol, way,chir, sw, pge, dinoprost , minoxidil....) ¿?
You recommend not to be on with this regimen indefinitely ..., but in many aggressive AGAs the maintain with only dutasteride and minoxidil is not sufficient... In that case which of these protocol products you would recommend to continue using with dutasteride ¿?
In reference to pathway RSPO2/ 3 Pegasus and john difool , are you using Infigratinib ¿?
You recommend not to be on with this regimen indefinitely ..., but in many aggressive AGAs the maintain with only dutasteride and minoxidil is not sufficient... In that case which of these protocol products you would recommend to continue using with dutasteride ¿?
In reference to pathway RSPO2/ 3 Pegasus and john difool , are you using Infigratinib ¿?
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Estriol has been shown to be safe long-term at around 10mg/day.
I just got my infigratinib finally in the last week. I'm doing a senolytic course right now, and I'll start using that after I finish at the end of the month.
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Regardless of whether you microneedle or not? I notice needled areas seem to darken, but if I apply without needling, there doesn't seem to be an effect.
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Everyone is different. Apparently some folks get side even on saw palmetto so it's hard to cookie cut what's working or not. This and how long you need to do it to see some results is why it makes this darn thing so hard to find a treatment for.
Ok , I guess that with Wnt activators its convenient will have rest-off
And sw033291 could be used long-term .... ¿? In the studies carried out with rats there are no adverse side effects even at very high doses... ,it would be interesting , for example in people not responding to minoxidil