HMI-115 PRLR antibody: The Most Promising Treatment Ever

[Dr sanches]

Take this to another thread

You have multiple trolling accounts

 

[RagnarLothbrok]

Forum going downhill pretty bad with late spammers who derail every single thread

 

[hairlossisevil]

Young teen balders will not maintain look at Reddit

They can. I'm one of them. Still NW2 at 44. And I'm actually a pretty poor responder. Never grew any hair. Just maintenance.

 

[Dr sanches]

They can. I'm one of them. Still NW2 at 44. And I'm actually a pretty poor responder. Never grew any hair. Just maintenance.

When did you start finasteride and how agressive was your balding lol you said you maintained for that long that’s impossible

 

[hairlossisevil]

When did you start finasteride and how agressive was your balding lol you said you maintained for that long that’s impossible

Started taking finasteride at 19. Been on finasteride most of my life. Been on both finasteride and dutasteride for at least 13 years.

As for how aggressive. Let's just say most of my male family and relatives are either NW7, died NW7 or on their way to NW7. My male pattern baldness is as aggressive as it gets. Including severe itching and inflammation which I treat with pretty regular use of hydrocortizone (extremely effective).

 

[Super Metroid]

HMI-115 is actually an interesting potential medication based on the macaque studies they did. Happy to see it going through trials and lets hope it is as effective and safe as we foresee. Would be nice to keep this topic only for relevant news

 

[Hairful]

They can. I'm one of them. Still NW2 at 44. And I'm actually a pretty poor responder. Never grew any hair. Just maintenance.

Take finasteride for a month, starts shedding. Oh noes, my hair got worse, finasteride doesn’t work.

 

[Dr sanches]

Started taking finasteride at 19. Been on finasteride most of my life. Been on both finasteride and dutasteride for at least 13 years.

As for how aggressive. Let's just say most of my male family and relatives are either NW7, died NW7 or on their way to NW7. My male pattern baldness is as aggressive as it gets. Including severe itching and inflammation which I treat with pretty regular use of hydrocortizone (extremely effective).

Well that’s incredible if you are 44 and started finasteride at 19 and have no hair loss

 

[Lokus423]

Vitamin B6 & Zinc is shown to lower prolactin levels. What do you guys think of this?

Zinc: an inhibitor of prolactin (PRL) secretion in humans - PubMed

The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women. Blood samples were collected at 10 and 30-min intervals over a period of 120 min after two basal times (-30 and 0 min). PRL...

pubmed.ncbi.nlm.nih.gov

The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women. Blood samples were collected at 10 and 30-min intervals over a period of 120 min after two basal times (-30 and 0 min). PRL concentrations significantly fell below basal levels in all subjects in response to the increase in plasma zinc levels, as compared to the controls. These results suggest that acute hyperzincemia can inhibit basal PRL secretion in normal individuals.

Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia - PMC

This study aimed to investigate the safety and efficacy of high-dose vitamin B6 (vB6) as an adjunct treatment for antipsychotic-induced hyperprolactinemia (AIHP) in male patients with treatment-resistant schizophrenia (TRS). In this randomized ...

www.ncbi.nlm.nih.gov

From baseline levels to the end of the 16 week study period, the vB6 group showed a 68.1% reduction in prolactin levels from 95.52 ± 6.30 μg/L to 30.43 ± 18.65 μg/L while the ARI group showed a 37.4% reduction from 89.07 ± 3.59 μg/L to 55.78 ± 7.39 μg/L.

 

[Dr sanches]

Vitamin B6 & Zinc is shown to lower prolactin levels. What do you guys think of this?

Zinc: an inhibitor of prolactin (PRL) secretion in humans - PubMed

The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women. Blood samples were collected at 10 and 30-min intervals over a period of 120 min after two basal times (-30 and 0 min). PRL...

pubmed.ncbi.nlm.nih.gov

Safety and Efficacy of High-Dose Vitamin B6 as an Adjunctive Treatment for Antipsychotic-Induced Hyperprolactinemia in Male Patients With Treatment-Resistant Schizophrenia - PMC

This study aimed to investigate the safety and efficacy of high-dose vitamin B6 (vB6) as an adjunct treatment for antipsychotic-induced hyperprolactinemia (AIHP) in male patients with treatment-resistant schizophrenia (TRS). In this randomized ...

www.ncbi.nlm.nih.gov

I think you are retarded because people over dose on those and don’t see anything.

 

[Lokus423]

I think you are retarded because people over dose on those and don’t see anything.

Maybe male pattern baldness has different etiology and lowering prolactin only works in those who have elevated levels leading to hair loss? I haven't read this thread, so I have no idea. Just seems strange to think a drug that lowers prolactin will work but taking natural vitamin pills that do the same won't. Why would this be?

 

[pegasus2]

Maybe male pattern baldness has different etiology and lowering prolactin only works in those who have elevated levels leading to hair loss? I haven't read this thread, so I have no idea. Just seems strange to think a drug that lowers prolactin will work but taking natural vitamin pills that do the same won't. Why would this be?

Might want to read the thread before posting. It's common internet etiquette.

 

[coolio]

Short answer:

The prolactin that is relevant for hair loss is being produced in the follicle. Monkeying with systemic prolactin levels doesn't help. It's different mechanisms.

 

[notoriousone]

CPA stimulates pituitary prolactin production. The hair follicle produces its own prolactin with a different promoter. Hair cycling is regulated by this autocrine prolactin production and not affected by serum prolactin unless the serum levesl become very high. CPA may not work in people whom it induces severe hyperprolactinemia. I wouldn't be shocked if it still worked though, because DHT upregulates the PRLR. By blocking the AR with CPA you would have less PRLR, and the intrafollicular levels of prolactin wouldn't increase that much, so it may be a net postitive.

This is the same reason why cabergoline and bromocriptine don't work. They reduce serum prolactin greatly by activating dopamine receptors in the pituitary gland. The Pituary gland responds by drastically reducing prolactin production. It's been shown that this has no effect on prolactin and PRLR expression in the hair follicle. They continue to produce their own. The intrafollicular levels are not upregulated or downregulated by the same mechanism as the pituitary gland

Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are the key factors in terminal hair growth. They act on...

www.mdpi.com

So what is your hypothesis on why people don't heavily shed on adderall then?

 

[pegasus2]

So what is your hypothesis on why people don't heavily shed on adderall then?

Adderall does cause hair loss, but what does that have to do with this? AFAIK it doesn't upregulate prolactin.

Also, I'm going to put this at the very top of the first post so that maybe people will read it:

dopamine, known as an inhibitor of PRL pituitary secretions, has no effect on PRL or PRL-R expression in human HFs

Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are the key factors in terminal hair growth. They act on...

www.mdpi.com

We also show that the catagen-promoting activity of PRL is independent of the hypothalamus-pituitary-adrenal axis and systemic hormone levels. It applies to HFs of a mammalian species with mosaic and seasonally independent HF cycling

 

[notoriousone]

Adderall does cause hair loss, but what does that have to do with this? AFAIK it doesn't upregulate prolactin.

Also, I'm going to put this at the very top of the first post so that maybe people will read it:

Hormonal Effects on Hair Follicles

The hair cycle and hair follicle structure are highly affected by various hormones. Androgens—such as testosterone (T); dihydrotestosterone (DHT); and their prohormones, dehydroepiandrosterone sulfate (DHEAS) and androstendione (A)—are the key factors in terminal hair growth. They act on...

www.mdpi.com

Are you claiming it causes shedding or progression of male pattern baldness? I've been taking adderall for about a year and haven't noticed anything out of the ordinary.

"Interestingly, dopamine, known as an inhibitor of PRL pituitary secretions, has no effect on PRL or PRL-R expression in human HFs [22]. The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase"

 

[pegasus2]

Are you claiming it causes shedding or progression of male pattern baldness? I've been taking adderall for about a year and haven't noticed anything out of the ordinary.

"Interestingly, dopamine, known as an inhibitor of PRL pituitary secretions, has no effect on PRL or PRL-R expression in human HFs [22]. The mechanism whereby prolactin directly regulates hair growth is connected with its inhibitory influence on hair shaft elongation and the premature induction of the catagen phase"

It doesn't cause male pattern baldness, just shedding. Obviously not in everyone who takes it.

I don't know why you bolded that

 

[Hairful]

They really need to figure out a way to target only the HF prolactin. That’s the cure right there for hairloss. But that’s easier said than done lol

 

[norwood_spotter]

i got post finasteride snydrome from
HMI-115 PRLR antibody treatment.

 

[corkmeister]

i have pre-finasteride syndrome