Italian Hair Loss Lotion To Hit The Market In 2016

[I.D WALKER]

http://www.ncbi.nlm.nih.gov/pubmed/19710188

 

[Swoop]

http://www.ncbi.nlm.nih.gov/pubmed/19710188

That study seems to suggest that both R- and S-equol have high bioavailability actually?

In conclusion, we defined in healthy adults the pharmacokinetics and disposition of the diastereoisomers of equol by uniquely using tracer stable-isotope-labeled analogs of S-(−)[2-13C]equol and R-(+)[2-13C]equol produced by novel chiral chemistry (38). Our findings showed that, in contrast with published data for the soy isoflavones daidzein or genistein (46, 47), both equol enantiomers have high systemic bioavailability, although R-(+)[2-13C]equol exhibits greater bioavailability than its diastereoisomer, S-(−)[2-13C]equol or a racemic mixture. The latter behaves differently, ie, has a slower uptake and lower peak plasma concentrations.

S-equol only seems to have somewhat of a lower peak plasma concentration in this study in comparison to R-equol but that's fine.

You can see overall that they are both pretty fast absorped but after 6-12 hours the plasma concentrations are already lessened by quite a bit. The half life isn't that long. That's why they also ran 2x a day dosages with S-equol in all the clinical trials (because of the pharmacokinetics). From what I have read in all other studies S-equol certainly absorbs very well through oral administration.

Anyway was just wondering since Brotzu says that S-equol contributes a great deal to this topical, so was surprised so few people are on s-equol. That supplement from Otsuka is 100% legit, no doubt.

 

[I.D WALKER]

Well my dear boy, only because YOU mentioned them.
https://www.otsuka.co.jp/en/index.php

 

[Hairismylife]

S-equol and finasteride which one is more effective?

 

[kuba197]

https://rivoluzionecapelli.blogspot...omment=1468870181335&m=1#c8543085863284264356

 

[Crespo88]

Is this hair lotion out on market? Where can I buy it?

 

[rlf]

https://rivoluzionecapelli.blogspot...omment=1468870181335&m=1#c8543085863284264356

I don't know, is this legal what they're doing?

 

[abcdefg]

Are there any cheaper s-equol supplements? So it sounds like you could take it orally then, but there are still very few suppliers it seems which kind of sucks because it keeps costs higher. Id like a cheap 15 or less a month s-equol supplier
The more I think about this I think I just want the s-equol screw the rest of it I just want to maintain

 

[bags]

No difference in libido, but then again i have only been taking it for a bit over a week. I am also on finasteride (for 9+months) and haven't gotten any sides yet so I may be an exception

May I ask your ethnic background. You said you had no sides from finasteride so if you don't mind I am just curious as to your lineage. Thanks.

 

[kuba197]

https://m.facebook.com/photo.php?fb...19153234987.2161079.1173584803&type=1&theater

 

[BTW]

https://m.facebook.com/photo.php?fb...19153234987.2161079.1173584803&type=1&theater

they keep saying brotzu published something in a dermatology journal, where is it

 

[gagost02]

they keep saying brotzu published something in a dermatology journal, where is it

Il Dermatologo anno XXXVII n.1-2015 marzo (in Italian language)

https://www.dropbox.com/s/7j1a99vibfyyc6r/Brotzu Il Dermatologo anno XXXVII n.1-2015 marzo.pdf?dl=0

 

[big_head]

Holy f***, this thread is getting really complicated and hard to follow. This is what I have gathered to sum it up for anyone looking for answers, someone correct me if I am wrong.

1. The lotion is expected some time in 2017. They are currently in trials.

2. The company and doctor behind this are reputable.

3. The ingredients involved COULD have a systemic affect on hormones like finasteride, but nobody knows for sure.

4. People are or have attempted to make a knock off lotion using ingredients but it's difficult and costly to do without a proper lab.

I am still eagerly awaiting this stuff. finasteride is not causing any regrowth yet 4 months in and I am almost thinking about starting minoxidil with the finasteride again. I just need some damn regrowth on my left temple. I am not asking for much.

 

[JLC]

Holy f***, this thread is getting really complicated and hard to follow. This is what I have gathered to sum it up for anyone looking for answers, someone correct me if I am wrong.

1. The lotion is expected some time in 2017. They are currently in trials.

2. The company and doctor behind this are reputable.

3. The ingredients involved COULD have a systemic affect on hormones like finasteride, but nobody knows for sure.

4. People are or have attempted to make a knock off lotion using ingredients but it's difficult and costly to do without a proper lab.

I am still eagerly awaiting this stuff. finasteride is not causing any regrowth yet 4 months in and I am almost thinking about starting minoxidil with the finasteride again. I just need some damn regrowth on my left temple. I am not asking for much.

1. The lotion has no time frame confirmed.

2. Yes Dr Brotzu is very credible

3. Brotzu said there was no side effects at all, he used the lotion on children.

4. Nobody yet has successfully made a lotion with the same ingredients. Someone from Italy is trying to at the moment.
Someone also made a lotion with not the same but related ingredients and showed what appeared to be growth of small vellus hairs on a previously slick bald head.

 

[abcdefg]

Quality and source of ingredients though is a pretty big deal with something like this. You can buy RU from lots of different places but how many of them meet all the purity and potency tick marks for the true high grade RU? Also consistently batch after batch because if not the results dont mean much, and the person taking it probably wont ever know.
There are lots of details to consider is buying a common supplement of equol and crushing/dissolving it into some solution the same as a pure liquid grade form made by a lab? All those details can and do matter in real life but many people on forums dont ever think or care about them. They just get the first/cheapest one they can and try it then proclaim 5 months later it does nothing.
So the source of getting these ingredients is pretty key.

 

[gagost02]

it is not costly at all to make such a lotion; i have just recently made a batch with the main ingredient (Equol) as well as Borage oil and Carnitine and the cost was minimal for the amount i was able to make. I've been using it for only a couple of days and also taking Equol orally but no results to report yet given short time frame. Anyone with half a brain can mix such a lotion up. Just look up how to make lotions on youtube and invest in some Equol, Carnitine, Borage Oil, Isopropyl Myristate and wax/coconut oil/essential oils (optional). All you need is a few bowls, a blender, some container(s) and a clean workspace.

Where did you purchase the S-equol? ..... And cationic liposomes (emulated)?

Professor Brotzu bought the S-equol in China (Wuhan HengHeDa Pharm Co - source Il Dermatologo anno XXXVII n.1-2015 marzo)

Thanks

 

[I.D WALKER]

Bought the Equol in pill format from Amazon - just search for Equolibrium from Nature's Sunshine; opened pills and mixed with Isopropyl Myristate which enables fast absorption of components (such as Equol for example) and is commonly used to make lotions, etc. DGLA s covered by using Borage oil; also mixed it with coconut oil, Carnitine, Vitamin D and some bees wax for cosmetics to give it some stiffness. It is not Brotzu's lotion and may not be effective, but it isn't that far off so i'm testing it out to see if any results can be had. I don't like to wait around for test results, especially when ingredients seem readily available off the shelf - it's a small investment for me and keeps me entertained (i like this sort of thing)

Macaronaroni, approximately what amount of s-equol is in each dosage of your custom blend,
and how often are you applying it?
My apologies for the oversight if you've already provided this info. Thanks and best of luck with your endeavors.

 

[I.D WALKER]

Thanks for your quick and detailed response.
For all intents and purposes, your methodology sounds just fine right now Macaronaroni.
Are you also using a "delivery vehicle" (for improving absorption) or atm do you find this measure superfluous?
Btw I saw the photo you shared of your novel cream and just wanted to say,
from where I sit, I'll score it high marks in presentation for it's nice, clear coloration and consistency.
while we await for more telling results, I'll be hoping it finishes with at least a bronze in the performance category.

 

[worm]

@I.D WALKER
I am usually more methodical when i mix my lotions/creams, but in this case i was a bit looser in the formula since i could not find any downsides of using too much Equol (i guess i'll find out). Anyways, i used 50 pills - each pill is 6mg so that means 300mg total added to the mix. The total batch is about 400ml / 13.5 oz which i divided into two containers. That means i should roughly have 0.75mg Equol / ml. Each application is about ~5ml (~1 teaspoon), which would mean for each application there should be at least ~ 3.75mg Equol.
I apply it once every night - the hair becomes instantly slick because of the oils i used in the mix but the Isopropyl Myristate reduces the oiliness and the wax stiffens it up so it is comfortable to wear. I haven't perfected the mix enough to be able to wear it outside as a real hair gel since i think it is still too liquid but honestly that would be super easy to do by simply adding a bit more wax when i mix this up. If i did that, i could easily have a full on hair gel that would be indistinguishable from other commercial products and actually smells pretty unbelievable (i added some essential oils to it).
It doesn't feel like a nuisance to apply and it is easy so i'll keep applying it unless it all of a sudden makes all my hair fall out (fingers crossed).
Side note - i also take 1 pill of Equol every morning so that is 6mg oral and ~3.75 topical.

Please keep us updated, I have my finger on the click to buy button as soon as i hear some good feedback from you

 

[I.D WALKER]

As for transdermal delivery i am relying 100% on the Isopropyl Myristate to do the job; with the oils in the mixture, it should do a fine job at carrying the Equol to the transdermal layers, though i am no scientist so this is more s in the mixture it trial and error (DIY science experiment!).

Good work!