Kintor has started Phase 3 trial in China for Pyrilutamide

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Modill

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@Min0 what about this?

Trichoxidil | Fagron Ibérica

www.fagron.es www.fagron.es

Please use google translator. They say:

Natural option for hair growth
37% reduction of follicles in telogen phase in only 90 days

Natural option for hair growth by stimulating the production of growth factors
KGF, IGF-1 and VEGF. It is a phytocomplex with specific fractions of vegetable oils.

Mechanism of action
Stimulates the gene expression of the growth factors KGF, IGF-1 and VEGF, involved in the proliferation of the cellular matrix, dermal papilla and vascular system.
dermal papilla and vascular system; increases the amount of extracellular matrix in the dermal papilla and maintains the follicle in anagen phase.

Properties
- Stimulates hair growth.
- Conversion of the telogen to anagen phase of the hair fiber.
of the hair fiber.

Applications
Topical use of 2.5 - 5%.
- Androgenetic alopecia.
- Alopecia areata.
- Telogen effluvium.
- Anagen effluvium.
 
Min0

Min0

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Modill said:
@Min0

@Min0 in 45 days we know that Pyri works, but in 10 years I never saw that CB works for any body.

best
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according to the internet, pyri doesn't work, but it did work for me. i'm hoping the same thing with CB. i just ordered a premade 2.5% CB solution from actifolic, i don't believe in mixing it myself, perhaps that's what's making the difference. i always buy premade

i hope it will be enough to maintain for me. and looks like it is a well designed drug that degrades in the bloodstream into other metabolites so it means less or no side effects.
 
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Modill

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Min0 said:
according to the internet, pyri doesn't work, but it did work for me. i'm hoping the same thing with CB. i just ordered a premade 2.5% CB solution from actifolic, i don't believe in mixing it myself, perhaps that's what's making the difference. i always buy premade

i hope it will be enough to maintain for me. and looks like it is a well designed drug that degrades in the bloodstream into other metabolites so it means less or no side effects.
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According to internet Pyri doesn’t work? Where?? I have read several posts on reddit from people that works for them.

I have also read from people that doesn’t work, but who knows, maybe they are on finasteride and they cannot notice the real effect. For me works as crazy, in fact, if I use 1ml at 0,5% I have libido (not 100% but yes 85%) and at this dosage, pyri regrow hair enough. The problem is I am noticing chest pain, and I don’t like it. Low libido is ok, but chest pain is not ok.

Anyone else can share experiences?
 
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badnewsbearer

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Min0 said:
according to the internet, pyri doesn't work, but it did work for me. i'm hoping the same thing with CB. i just ordered a premade 2.5% CB solution from actifolic, i don't believe in mixing it myself, perhaps that's what's making the difference. i always buy premade

i hope it will be enough to maintain for me. and looks like it is a well designed drug that degrades in the bloodstream into other metabolites so it means less or no side effects.
Click to expand...
on CB there should be no sexual dysfunction, I think the molecule degrades into cortisone in the blood and that has no anti androgenic activity. thats why I find it so sad that Cassiopea is such a poorly managed company and thanks to covid as well there have been no further trials. I think people got stupid because of the 12 months phase 2 results. lets not forget that CB after 6 months was better than finasteride and on par with pyrilutamide in terms of hair growth. sure, the results got worse but it shows it gets to the hair follicle and does something there to at least mitigate the damage quite a bit. this could have been a legit product but its like a curse on this field, like a law of physics that no product shall ever pass phase 2 in hair loss research. its absurd. haven't heard about recruitment for phase 3 either. they said it'd be on the shelves in 2021 back in 2018 and now they dont even have another trial done. at this point id not be surprised if it never comes out. which would be insane because the product is already on the market in a different formulation so they have the safety data and they have the manufacturing all in place already they literally just make a second product and put a different label on it and done. its so retarded. I hope this works for you and that it'll be easier to acquire in the future and that this stupid company moves forward at some point. they even talked about "well FDA application might be quick for Breezula because we already have the drug on the market". I feel like covid damaged them quite a bit, its an Italian company as well and that was particularly affected in 2020 when they planned their phase 3 trial. such a shame
 
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badnewsbearer

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Min0 said:
according to the internet, pyri doesn't work, but it did work for me. i'm hoping the same thing with CB. i just ordered a premade 2.5% CB solution from actifolic, i don't believe in mixing it myself, perhaps that's what's making the difference. i always buy premade

i hope it will be enough to maintain for me. and looks like it is a well designed drug that degrades in the bloodstream into other metabolites so it means less or no side effects.
Click to expand...
 
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on their website it says

"Based on these results, we have selected the 75 mg BID dose for the phase III study, discussions are ongoing with the FDA and pending the successful outcome of these discussions we expect to commence the phase III trial in the second half of 2022."
 
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supermusic

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Rather than lower the dose, I would try to leave the lotion on the scalp for less time. leave it just a little while to make its anti-androgen effect and then remove it from your scalp.

If you leave it working for hours, at the end part of the substance will end up entering the body and that is when the problems come. I think It is not necessary, even a simple shampoo like ketoconazole 2% has been proven to have some anti androgen effect and we only let it act for a few minutes on the head.

I remember there was a guy who would upload videos on YouTube of himself applying Minoxidil foam, which he would leave on his scalp for only a short time and still had very good results for a while.
 
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supermusic said:
Rather than lower the dose, I would try to leave the lotion on the scalp for less time. leave it just a little while to make its anti-androgen effect and then remove it from your scalp.

If you leave it working for hours, at the end part of the substance will end up entering the body and that is when the problems come. I think It is not necessary, even a simple shampoo like ketoconazole 2% has been proven to have some anti androgen effect and we only let it act for a few minutes on the head.

I remember there was a guy who would upload videos on YouTube of himself applying Minoxidil foam, which he would leave on his scalp for only a short time and still had very good results for a while.
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It is a good idea. Maybe to do put it in the shampoo, so we could apply the shampoo 5 min each day instead of using 1 ml that will stay at the scalp all day
 
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Hope111

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Modill said:
It is a good idea. Maybe to do put it in the shampoo, so we could apply the shampoo 5 min each day instead of using 1 ml that will stay at the scalp all day
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Before adding it to the shampoo, I would apply it for a while before taking a shower.
 
DAVAT

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Modill said:
It is a good idea. Maybe to do put it in the shampoo, so we could apply the shampoo 5 min each day instead of using 1 ml that will stay at the scalp all day
Click to expand...

If this worked it would be incredible. for many its just not practical to apply topicals and leave it in
 
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DAVAT said:
If this worked it would be incredible. for many its just not practical to apply topicals and leave it in
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To put it in shampoo is not really a good idea because Pyri would be in contact with your hands and your full body.

It would be better to apply in the scalp, wait 5 min and then have a shower to remove it
 
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Ralph Wiggum

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75% of topical Minoxidil is absorbed after four hours, what is it that is making people think that Pyrilutamide can be washed off after five minutes?
 
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supermusic

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50% of Minoxidil is absorbed in the first hour. It is simply a matter of testing whether with less time of exposure to these antiandrogenic substances we obtain benefits with fewer or no side effects.
 
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Modill

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I definitely have not found a balance with Pyrilutamide. Even if I use a very small amount, the product must bioaccumulate in my body and I end up losing libido and erections, but that's not the worst. The worst thing is that it affects my heartbeat, so it's over.

I have purchased TrichoXidil, and I also have CB 2.5% which I will start using after a week or 2 as I want my body to get rid of the Pyrilutamide.
 
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