Please wait until the end of 2021, the volunteer data will be published, and if the results are good, it can be put into production. I am not worried about the speed of construction in our country when it comes to production lines.
Kintor new AR degrader w/o side effects
- Thread starter FollicleGuardian
- Start date
-
- Tags
- ar degrader kintor
- Reaction score
- 732
Does it need to complete phase 3 in China? How fast can we buy it in China do you think? I heard Kintor already have a deal in place with JD Pharmacy for selling it.
- Reaction score
- 614
Proxalutamide will probably make it out first from their line up. Pretty long half life but I'm sure people on here will be willing to try it regardless.
- Reaction score
- 637
Prox has a >500 dalton size. Could be helpful to reduce systemic absorption if it was made into a topical
Are you talking about the AR degrader (GT20029) or Pyrilutamide?
KX-826
Thanks. Do you know more about GT20029?
- Reaction score
- 614
If we can get our hands on it it works to our benefit. Pricing could be an issue though if it's just going to be one of those extortionate insurance-only drugs.
That's not their core product right now. I don't know much about that
Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China
/PRNewswire/ -- Kintor Pharmaceutical Limited (stock code 9939.HK, "Kintor Pharmaceutical" or the "Company"), a clinical-stage biotechnology company developing...
www.prnewswire.com
- Reaction score
- 70
Kintor is now worth 2.3bn compared to Cassiopea with 526m and I think the COVID medication is not the only driver behind it. Pretty impressive if you ask me also if you compare it with with CRISPR being worth only four times more. So I'm pretty sure the science behind is legit and we'll see a speedrun through clinical trials. I can't wait to see how effective the treatment will be.
- Reaction score
- 188
Hey guys, check out the following link: https://www.zhihu.com/question/436422609 (second post in thread)
Google Chinese translation isn't perfect but this seems to be someone in the P2 pyrilutamide trials sharing progress pics and discussing efficacy? Can anyone translate?
Google Chinese translation isn't perfect but this seems to be someone in the P2 pyrilutamide trials sharing progress pics and discussing efficacy? Can anyone translate?
- Reaction score
- 70
You dug deep for that, well done! Yeah looks like not much has changed for him even though they attested him efficacy when he went back to check with the doctor. And if I understood that correctly he also reported that it worked better on some people who were balder than him. Very interesting find but we don't know if he was in the placebo group. Still if someone is curious there is your contact
Yes, this is the pyrilutamide (KX-826) trial.
He thinks he might be in the placebo group (from his other comments) or that he's had very slight improvement. He says that other people have had more significant improvements. 0 side effects.
Someone else said that the phase 2 trials could possibly conclude by the end of June with data coming out sometime Q3.
3 months into treatment he wasn't going to see much regardless. I see new follicles where he's "bald" in the temples though, but the first pic could just not be zoomed in enough.You dug deep for that, well done! Yeah looks like not much has changed for him even though they attested him efficacy when he went back to check with the doctor. And if I understood that correctly he also reported that it worked better on some people who were balder than him. Very interesting find but we don't know if he was in the placebo group. Still if someone is curious there is your contact
He could have easily been placebo.. also, this wouldn't be a growth drug anyways just the same as RU isn't one. Didn't you guys say that this stuff has 2-3x the binding affinity of RU? If you're using RU there would be no reason to doubt this could work.
Exactly, but people on here really go around thinking an AR antagonist will grow back their hair. RU does to a good degree, but I doubt any AR antagonist can beat it significantly. There's a max that can be achieved through this mechanism and RU is pretty much it.