My point wasn't that you can't restore hair follicles that are beyond that point, it was that they won't restore themselves just because you block the AR. As Cotsarelis said, if you castrate someone they won't grow their hair back, if you also give them estrogen they might. Targeting the androgen receptor stops hair loss, but it won't repopulate the missing progenitor cells and activate the stem cells in the HM that repopulate the DP, only adding estrogen seems to do that.
Kintor new AR degrader w/o side effects
- Thread starter FollicleGuardian
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- ar degrader kintor
My question would be does it make it easier to achieve that once the AR is fully blocked. Either way, an ideal treatment seems to be a estrogen topical that only binds to the follicle cells through an antibody. New mnAb science has a very clear pathway to targeting certain cells and receptors, they're just very expensive to develop.
Meh they could get it on the market in 2.5-3 years in China if all goes well and they are well funded. They've taken 2-3 month breaks between phases for Pyralutamide. If they do the same with the Protac it would be in phase 2 late 2021 and phase 3 by late 2022 for an early 2024 launch.
They also just got approval for their IND in the USA for the protac as well, which means they could be doing a phase 1 in the US in 2021. Looking like 4-5 years for US approval.
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Is anyone working on anything like that?
Probably not. Average cost to patients of these drugs is high 5 figures to low 6 figures for a year. No one would develop that for hairloss.
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First dose delivered today in phase 1 Chinese trials
www.prnewswire.com
Kintor Pharmaceutical Announces Dosing of First Batch of Subjects in Phase I Clinical Trial of GT20029 in China
/PRNewswire/ -- Kintor Pharmaceutical Limited (HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecule and biological...
www.prnewswire.com
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This I think has a lot of promise. If this succeeds then we are all savedFirst dose delivered today in phase 1 Chinese trials
Kintor Pharmaceutical Announces Dosing of First Batch of Subjects in Phase I Clinical Trial of GT20029 in China
/PRNewswire/ -- Kintor Pharmaceutical Limited (HKEX: 9939), a clinical-stage biotechnology company developing innovative small molecule and biological...
Someone on this forum cut off his testicles and still didn't grow his hair back. Stopping AR signaling isn't going to reverse hair loss
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That’s largely becuase that also crashes estrogen since it can no longer be converted from testosterone. This is why blocking AR receptors with drugs like bica can produce such great improvements in density and hair diameter.
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It amazing how much faster this is moving in China, the US FDA has fucked all of us so hard
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I'm talking about prevention not a cure.
Never seen bica get good results without exogenous estrogen
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How many bica results have you even seen though? I know a few people only to use bica solo for more than 3 months and they all had great regrowth and never visit these forums or discords anymore
Only on these forums and reddit. Studies show poor regrowth with it in women and they have a lot more estrogen than we do. Some people do get really good results from finasteride. I'd argue these are the people getting good results from bica, but it's not the norm and it's not a cure
This makes me incredibly happy, thanks for sharing. God speed kintor.
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Actually in the studies I’m aware of most of the women were either happy or very happy with their results but keep in mind the obvious, female hairloss is far more aggressive than male hairloss so it was never a good comparison anyways. I only know of good results from long term usage in males
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Female hair loss is more aggressive?
That's because China is willing to sacrifice safety and even efficacy to allow it's companies to grow. It's not exactly universally a good thing, even though I do agree that the FDA is on the complete other end of the spectrum and f*****g over people who desperately need access to new treatments because they have failed to adapt their drug trial/screening process for the modern technological age.
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Sacrifice a few people now to save millions in the future. I'm ok with it lol
But jokes aside, I remember they set gene editing back big time when they had those gene editing deaths 20 years ago. We could have been much further with the technology by now had they been more cautious
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this is by far the most novel and interesting approach from a scientific perspective. all the other half hearted attempts of using growth factors by companies like histogen or that swedish company with their booster compounds are just shots in the darkness with the hopes that something hits, its non strategic drug development.
this is quite similar to the approach of the company Olix with the difference that Olix is trying to inhibit the production of AR after transcription, this one is the post translational approach where the AR protein has been formed and is now getting degraded. both could yield the same results if effective and even combined to assure a total nonexistence of AR in dermal papilla cells.
another interesting approach that in my opinion should be pushed forward by these companies is to also target the obvious, the 5AR enzyme which is also a protein and it can also be either inhibited post translation by iRNA for example or it could get degraded by a kintor compound, all they would really need to do it seems is to exchange the recruiting element POI from the AR recruiter to the 5AR recruiter. and then you have it, a combined androgen receptor, 5Areductase enzyme degrader. that would be extremely potent. sadly kintor seems to plan to target the AR for now only. but Olix seems to be interested in both targets from what i have read
this is quite similar to the approach of the company Olix with the difference that Olix is trying to inhibit the production of AR after transcription, this one is the post translational approach where the AR protein has been formed and is now getting degraded. both could yield the same results if effective and even combined to assure a total nonexistence of AR in dermal papilla cells.
another interesting approach that in my opinion should be pushed forward by these companies is to also target the obvious, the 5AR enzyme which is also a protein and it can also be either inhibited post translation by iRNA for example or it could get degraded by a kintor compound, all they would really need to do it seems is to exchange the recruiting element POI from the AR recruiter to the 5AR recruiter. and then you have it, a combined androgen receptor, 5Areductase enzyme degrader. that would be extremely potent. sadly kintor seems to plan to target the AR for now only. but Olix seems to be interested in both targets from what i have read