Kintor Pharmaceuticals Furthers Baldness Treatment Drugs In Us And China

[Dimitri001]

Why would they be pushing forward 3 trials for it in the USA then? Acne and 2x Androgenetic Alopecia phase 2 are greenlit in the USA. If there was bunk science or poor methodology then the FDA wouldn't have already approved phase 2 after the USA phase 1 was successful.'

You can literally go look at the data yourself instead of posting bull sh*t. The phase 1 report has all the measurable serum levels by dose, including the trace serum concentrations by hour for all tested doses. We can literally see that the tested dose serum concentration was not measurable, while 2.5x the dose is where it becomes measurable in serum. So what are you even talking about?

Wow, not detectable in blood at tested dose? If tested dose is the dose intended for use that sounds good!

Where can this data be found?

 

[trialAcc]

Wow, not detectable in blood at tested dose? If tested dose is the dose intended for use that sounds good!

Where can this data be found?

Google the US or China phase 1 report. I've also posted it into this thread before.

 

[badnewsbearer]

This is the best I've learned about this drug, thanks to @pegasus2. Since then, everyone else has tried to avoid reading his post and keep posting BS about the company and the product or even the country where it's been developed. It's embarrassing beyond belief.

this is a direct quote of kintor though so of course it positive

 

[Flamingflaps]

who in their right mind would spend 1000$ a year to rub a topical into sour head twice a day just to have to stack it with other sh*t too?

I would. A lot on this forum would. As long as it was sideless and stacking it with finasteride provided a better result than either drug alone, why not? General public, possibly not - many would choose one or the other.

 

[badnewsbearer]

I would. A lot on this forum would. As long as it was sideless and stacking it with finasteride provided a better result than either drug alone, why not? General public, possibly not - many would choose one or the other.

well this is supposed to be an alternative to nuking your dht not an adjunct and another drug exposure. its no point if you have to combine it with finasteride still which many people dont tolerate. I do not see a big market opportunity for them, complacency with a topical in advanced diffuse stages in particular is a huge issue as well. I honestly think people who do not respond or cannot tolerate finasteride are pretty much f*****g for a good 10-15 years still

 

[Chads don't bald]

This is probably a stupid question but can pyrilutamide come in an oral form or will it have to be topical. I'm guessing there is no way for oral to localize to hair follicles only so topical will be the only way to go, but just curious.

Because if you already have mostly a full head of hair (NW2 ish), then applying a topical in areas you already have hair to prevent further hair loss will probably be a pain in the *** compared to taking finasteride.

 

[badnewsbearer]

you wont take it as oral or youll get serious sexual sides irs a very potent AA

 

[Chads don't bald]

Yeah but is there any way to localize an oral drug only to hair follicles

I'm guessing we don't have that kind of technology yet but just curious

 

[Willoway]

How Many More Times (Remaster) - YouTubehttps://www.youtube.com › watch

 

[John Difool]

Actually if we have a volunteer to try it oral like this gentleman, it would be interesting to understand what would be his hair regrowth.

 

[Kagaho]

what do you mean? like it took 30 years to get a topical anti androgen thaz does not even work as good as finasteride and still needs to be stacked with other drugs?? then that is not a maintenance treatment. who in their right mind would spend 1000$ a year to rub a topical into sour head twice a day just to have to stack it with other sh*t too? most people would never commit to that. andgood to know it will be so weak so thaz people with actual hair loss cant even benefit.and you are just plain wrong, hair count and hair weight and anagen telogen ratio are the only thing that mattersx pictures are pretty much useless, not usekess but theyunderlie more error and are not as exact. hair could and diamter are true indicators and how can yoi have a drug and sell it as a hair loss treatmenr when you do not know if it works for even a year??

Dude, Its not hard to understand. Target area hair count measures a prefixed tiny area of a few cm2. Human hair cycles asynchronously and therefore the impact on the numbers may not be related to the total cosmetic appearance. Even more so if it is in the long term. It suit best for measuring growth stims or the short term impact on hair growth.

ARIs or AAs are preventative therapies. Its been known for ages, since Hamilton studies in the 60s. So given their intrinsic nature long term investigator evaluation by HD Photographs as primary efficacy variable is the best way to go.

https://www.bernsteinmedical.com/downloads/Rossi_Finasteride_10Yr_%202011.pdf

They were evaluated by using a color standardized macrophotograph (Canfield Imaging Systems, Fairfield, NJ) before starting the treatment (baseline), after 1, 2, 5, and 10 years of treatment. At each follow-up, the photos were examined by the same three experts (two dermatologists experienced in assessment of changes in scalp hair growth and one junior dermatologist).
Together, the experts assigned to each subject a value (a score) from -3 (greatly decreased compared to the baseline) to +3 (greatly increased compared to the baseline); a value of 0 specified an unchanged hair state. The study was carried out at the Department of Dermatology and Plastic Surgery, Sapienza Medical School of Rome, Italy

@badnewsbearer

o in their right mind would spend 1000$ a year to rub a topical into sour head twice a day just to have to stack it with other sh*t too? most people would never commit to that. andgood to know it will be so weak so thaz people with actual hair loss cant even benefit

You're exaggerating what I said. Not everyone is going to need to use finasteride-dutasteride & Pyri- CB of course. They are drugs with potentially synergistic mechanisms of action, if KX manages to pass clinical trials it will be one more alternative to stop the most complicated cases.

 

[LouisSarkozy]

This is the best I've learned about this drug, thanks to @pegasus2. Since then, everyone else has tried to avoid reading his post and keep posting BS about the company and the product or even the country where it's been developed. It's embarrassing beyond belief.

sorry to ask but what would be the vehicle we could used for pyr? if their i no pg involved

 

[Chads don't bald]

Actually if we have a volunteer to try it oral like this gentleman, it would be interesting to understand what would be his hair regrowth.

I'm definitely not volunteering haha, just wondering if there is anyone in biotech developing a drug delivery system which can localize drugs to certain parts of the body

Do you think this would cause much regrowth anyways? I would assume it's more for maintenance right?

 

[badnewsbearer]

s

Dude, Its not hard to understand. Target area hair count measures a prefixed tiny area of a few cm2. Human hair cycles asynchronously and therefore the impact on the numbers may not be related to the total cosmetic appearance. Even more so if it is in the long term. It suit best for measuring growth stims or the short term impact on hair growth.

ARIs or AAs are preventative therapies. Its been known for ages, since Hamilton studies in the 60s. So given their intrinsic nature long term investigator evaluation by HD Photographs as primary efficacy variable is the best way to go.

https://www.bernsteinmedical.com/downloads/Rossi_Finasteride_10Yr_%202011.pdf

@badnewsbearer

You're exaggerating what I said. Not everyone is going to need to use finasteride-dutasteride & Pyri- CB of course. They are drugs with potentially synergistic mechanisms of action, if KX manages to pass clinical trials it will be one more alternative to stop the most complicated cases.

this is again inaccurate. haircount is the only scientific way to go about. i woukd say equally important is hair weight so diamter which is largely fesponsible for the cosmetic appearance. whenyou bald two things happen, the anagen to telegon ratio is continiously loweres and this is captured by a decrease in hair count. inaddition further minaturization and depletion of dermal papilla makes the hairs thinner and that is captured in hair weight. themajority of men experience an improvement in their hair on finasteride meaning, finasteride promotes anagen to telegon ration increase as well as an increase in hair weight. thatis regrowth. mostpeople do experience this and the reason is simply. the body has some self renewal capabilities itself and if you do not completely bombard the har root with androgens it can obviously regenerate itself a bit whoch is why some people experiende such amazing regrowth on anti androgens. anti androgens allow the DP to excrete growth factors and cellular signaling molecules again leading to recovery in many especially young men where cell senesence is low.

this is a legitimate way ro measure how effective a drug is. ifkintor does not beat finasteride on those mentrics i think it is quite worthless and a huge dissapointment it means ir cant address the root prpblem

 

[Kagaho]

Inaccurate? And what do you think its evaluated on pics? I think its hair diameter, my man. And what you are failing to see, most of the scalp is under scrutiny, not a small prefixed area. But its pretty obvious you want to believe topical antiandrogens are useless. Maybe you are beyond NW3

 

[trialAcc]

sorry to ask but what would be the vehicle we could used for pyr? if their i no pg involved

Just any non-pg vehicle. Lots of companies like minoxidilmax or anywhere that sells RU sell stock non-pg solutions.

 

[trialAcc]

Inaccurate? And what do you think its evaluated on pics? I think its hair diameter, my man. And what you are failing to see, most of the scalp is under scrutiny, not a small prefixed area. But its pretty obvious you want to believe topical antiandrogens are useless. Maybe you are beyond NW3

No. The measurement count for KX is non-vellus new terminal hair count, which is a better measurement standard than CB used in their trials. CB tested for new hair count including vellus, which is probably why the gain at 6 months was so high and people were so impressed by 6 month results, when in reality the drug was strong enough to allow some vellus to grow but nothing more. KX will certainly have better interim results then CB, it's a much stronger compound.

Diameter was not a primary end point, maybe secondary though you'd have to check.

The results will have a 10%+ increase in hair count (almost guaranteed), but remember this is 6 months. The staying power of results will be unknown.

 

[badnewsbearer]

Inaccurate? And what do you think its evaluated on pics? I think its hair diameter, my man. And what you are failing to see, most of the scalp is under scrutiny, not a small prefixed area. But its pretty obvious you want to believe topical antiandrogens are useless. Maybe you are beyond NW3

for aure i am beyond Norwood 3 what kind of shitty treatment is it for who, a bunch of middled aged insecure men with mature Norwood 2-3 haielines, its not a hair loss product rhen. sadlynothing will beat finasteride until 2035 at least

 

[badnewsbearer]

No. The measurement count for KX is non-vellus new terminal hair count, which is a better measurement standard than CB used in their trials. CB tested for new hair count including vellus, which is probably why the gain at 6 months was so high and people were so impressed by 6 month results, when in reality the drug was strong enough to allow some vellus to grow but nothing more. KX will certainly have better interim results then CB, it's a much stronger compound.

Diameter was not a primary end point, maybe secondary though you'd have to check.

The results will have a 10%+ increase in hair count (almost guaranteed), but remember this is 6 months. The staying power of results will be unknown.

i think CB used temrinal hair count no?

 

[John Difool]

Why don't you ask them

I'm definitely not volunteering haha, just wondering if there is anyone in biotech developing a drug delivery system which can localize drugs to certain parts of the body

I think it's more complicated than what you are picturing in your head. Leave it to the big boys in white blouse.

Do you think this would cause much regrowth anyways? I would assume it's more for maintenance right?

Who knows. We've seen people regrowing on Fina and people balding on HRT. So who can predict what it will do to YOU?