Kintor's Pyrilutamide outcompetes RU-58841 (insane binding affinity)+ potential compound reveal?

[Isneezedsohard]

No

crap lol

 

[whatevr]

Sad. So there is literally nothing for male pattern baldness besides the BIG 3.

Hope stemson is legit and comes out sooner or later

The people designing topilutamide had the right idea - unfortunately the end product was too weak.

These guys look like they just made the strongest antiandrogen they could, but with that half-life and being non-degrading in the bloodstream, they didn't take real world usability into account.

 

[Pls_NW-1]

The people designing topilutamide had the right idea - unfortunately the end product was too weak.

These guys look like they just made the strongest antiandrogen they could, but with that half-life and being non-degrading in the bloodstream, they didn't take real world usability into account.

We still dont know how it actually works. They gotta publish more data, maybe it will be safe. We shall see... it actually looks like a good maintenance drug, but as of side effects... mh

 

[whatevr]

We still dont know how it actually works. They gotta publish more data, maybe it will be safe. We shall see... it actually looks like a good maintenance drug, but as of side effects... mh

Honestly I think the AR degrader has more potential to be side-effect free than this 'classic' anti-androgen. More powerful, too.

 

[Pls_NW-1]

Honestly I think the AR degrader has more potential to be side-effect free than this 'classic' anti-androgen. More powerful, too.

Yeah I share your opinion, nevertheless, Kintor is actually trying something. I like it! With dedication you actually 'can' cure your male pattern baldness, at best, when you catch it early.

 

[Pls_NW-1]

Hope new treatment comes out so we can maintain till a good solution, like the stempson solution, comes out

 

[el_duterino]

This Kintor seems to be the typical Chinese company coming strong and fast with bold and inflated claims without much of the groundwork being done to backup their claims.

If they seriously think that a super strong anti androgen with a super long serum half life is going to work in dermatology, they are either kidding themselves or just trying to propup stock prices.

I haven't seen the studies on the AR degrader - maybe someone can post a link - lets hope this is better

 

[Isneezedsohard]

This Kintor seems to be the typical Chinese company coming strong and fast with bold and inflated claims without much of the groundwork being done to backup their claims.

If they seriously think that a super strong anti androgen with a super long serum half life is going to work in dermatology, they are either kidding themselves or just trying to propup stock prices.

I haven't seen the studies on the AR degrader - maybe someone can post a link - lets hope this is better

I'm gonna try and stay optimistic. I'm sure it'll suck balls... but im gonna chose to think it'll be great

 

[trialAcc]

This Kintor seems to be the typical Chinese company coming strong and fast with bold and inflated claims without much of the groundwork being done to backup their claims.

If they seriously think that a super strong anti androgen with a super long serum half life is going to work in dermatology, they are either kidding themselves or just trying to propup stock prices.

I haven't seen the studies on the AR degrader - maybe someone can post a link - lets hope this is better

Why would they throw millions into trials in the US if they knew the product was going to fail?

 

[Tom4362]

Why would they throw millions into trials in the US if they knew the product was going to fail?

Yeah exactly. They are conducting trials in both China and the US simultaneously, you would't expect them to do this if they weren't sure

 

[trialAcc]

Yeah exactly. They are conducting trials in both China and the US simultaneously, you would't expect them to do this if they weren't sure

Yep. They'd actually probably want to stay as far away as possible from the US FDA process if they were doing trials just to boost the image of their company. The more rigorous trial requirements and safety checks will poke holes in their drug pipeline and end up hurting the company image.

 

[Shush]

I understand that we got burnt many times by false and deceiving claims, but these guys look really serious : low profile, little talk and moving forward. I'm very confident about this one, facts speak for themselves

 

[Briandesigns]

Honestly I think the AR degrader has more potential to be side-effect free than this 'classic' anti-androgen. More powerful, too.

Does the AR degrader only target scalp AR? If not then wouldn't it prevent DHT from binding to the ARs in genitals(and other places where you actually want DHT) and cause noodle anyway?

 

[John Difool]

I think any AA used for PC is absolutely awesome for hair especially second generation non steroid ones. The problem using anything topical is the systemic build up because haof life. You don't have to wait for this AA to use one. And I doubt it wouldn't go systemic if they call PC in the patent. Using Bica Daro Enzo will get you there. I am more interested about the down regulatir because as @pegasus2 was saying ASC-J9 is s real b**ch to manage discreetly.

 

[Micky_007]

Phase 2 is almost done and phase 3 starts this year. So you would not expect side effects to be an issue

I agree with @el_duterino and @whatevr about the highly possible side effects.

We've already seen drugs, such as Finasteride, that have passed FDA approval but clearly a lot of people get side effects. And it was only after a decade since its came to market, only then were a substantial amount of studies done that proved there were much more side effects than initially claimed.

So just because something is FDA approved, doesn't necessarily mean something is safe.

Also, Finasteride was far less potent than Pyrilutamide will be so there's an even higher probability of sexual or even mental side effects.

But time will tell.

 

[frank33]

I agree with @el_duterino and @whatevr about the highly possible side effects.

We've already seen drugs, such as Finasteride, that have passed FDA approval but clearly a lot of people get side effects. And it was only after a decade since its came to market, only then were a substantial amount of studies done that proved there were much more side effects than initially claimed.

So just because something is FDA approved, doesn't necessarily mean something is safe.

Also, Finasteride was far less potent than Pyrilutamide will be so there's an even higher probability of sexual or even mental side effects.

But time will tell.

Finasteride has a different MoA, so the two are not comparable.
I agree that there's a pretty big chance of this causing side effects, but i guess clinical trials will tell us something more.
I think i've read that phase 1 studies had not showed sexual side effects, which doesen't mean it's 100% safe, but considering its insane affinity, it is a good first step in the right direction.

 

[inmyhead]

I haven't done proper research on this, but what's the binding affinity of this to the AR? And in comparison to other AA?

Do we also know something about this for the, in-development, AR degrader?

Dude, that's literally written in the first post.

 

[Micky_007]

Finasteride has a different MoA, so the two are not comparable.
I agree that there's a pretty big chance of this causing side effects, but i guess clinical trials will tell us something more.
I think i've read that phase 1 studies had not showed sexual side effects, which doesen't mean it's 100% safe, but considering its insane affinity, it is a good first step in the right direction.

If pyrilutamide goes systemic as an anti-androgen, which is very possible, it would have similar side effects as Finasteride which is also an Anti-androgen.

I am glad Kintor is working hard and fast though, but the safety is of main concern.

At this current moment, based only on the information we have now, I feel Kintors AR degrader is going to be far more safer and effective treatment for everyone.

 

[Tom4362]

I agree with @el_duterino and @whatevr about the highly possible side effects.

We've already seen drugs, such as Finasteride, that have passed FDA approval but clearly a lot of people get side effects. And it was only after a decade since its came to market, only then were a substantial amount of studies done that proved there were much more side effects than initially claimed.

So just because something is FDA approved, doesn't necessarily mean something is safe.

Also, Finasteride was far less potent than Pyrilutamide will be so there's an even higher probability of sexual or even mental side effects.

But time will tell.

According to the scientific literature the incidence of getting sides from Finasteride is still low.

The MoA is also very different from finasteride

 

[trialAcc]

I agree with @el_duterino and @whatevr about the highly possible side effects.

We've already seen drugs, such as Finasteride, that have passed FDA approval but clearly a lot of people get side effects. And it was only after a decade since its came to market, only then were a substantial amount of studies done that proved there were much more side effects than initially claimed.

So just because something is FDA approved, doesn't necessarily mean something is safe.

Also, Finasteride was far less potent than Pyrilutamide will be so there's an even higher probability of sexual or even mental side effects.

But time will tell.

None of this is really true. finasteride/Pry are completely different drugs with different methods of action and delivery methods, so to say that there is a higher probability of any sides is just useless speculation at this point.

In addition, many independent studies have shown finasteride side effects to be in a similar range to the original studies, which is still low and largley reversible when you stop the drug. What the studies can't really test for is longer term issues that might develop outside of the trial scope, which is why it does remain true that FDA approval doesn't equal long term safety for all drugs. Doesn't mean that the drugs that pass FDA are not generally "safe" from the perspective in which we view drug safety. These drugs just happen to be for "cosmetic" purposes rather then to stop or prevent serious health issues.