Kintor's Pyrilutamide outcompetes RU-58841 (insane binding affinity)+ potential compound reveal?

[John Difool]

Atleast we agree on something that the under 2% or even under 5% side effects rate is absurd.

However, the rest are not all from law suits. They are separate, I intentionally put the years there and different Medical Professionals* who conducted those studies. They are definitely not nonsense. There's atleast 8 different studies there all claiming the side effects are much worse than Finasteride.

Yes there is one post regarding 1100 Law Suits filed against Merck from people in America alone which Merck had to pay out a whopping $4.3 million.

Blocked. I don't have time reading stupid posts like this.

 

[Micky_007]

Ibuprofen was launched as a treatment for rheumatoid arthritis in the United Kingdom in 1969, and in the United States in 1974. Later, in 1983 and 1984, it became the first NSAID (other than aspirin) to be available over the counter (OTC) in these two countries.

Ibuprofen has side effects too. If it's bad for you, stop using it.

Honestly for you to come crashing a thread on an AA and start your propaganda on Finasteride one more time is wrong. You demonstrated your lack of knowledge by wrongly categorising the drug you are criticising so I would suggest you do some home work first then create your own thread preferably not in the science & study section of this forum and witness the number of visitors interested in your diatribes. Good luck.

They are all anti-androgens technically. General HRT usage though limits the term AA to Bica, spironolactone and CPA.

Yes, the difference is that "AA's" block receptor sites. Reductase inhibitors like Serms for estrogen, are targeted at a specific androgen, DHT. Medroxyprogesterone lowers T in general as does progesterone.

Janey Elizabeth explained it well. Yes I'm aware they have different MoA however, they all are technically anti-androgens.

Although, I will admit I do not like the turn this thread has taken being a discussion about Finasteride when the thread was intended for Kintors Drugs.

Let us all rather get back to discussing Kintors.

 

[Micky_007]

What is abhorrent is the attempt to force the product off the market. This to me indicates a lot of busy-bodies who don't want others to have the same choice that they had. Plus, balding people want others to go bald, subliminally so that they don't stand out. YMMV, indeed.

I would never want anyone to go bald. I do believe there's several other treatments that can be used instead of Finasteride that are often equally or more effective with less or no side effects.

 

[frank33]

Surfing this forum simply gives you a distorted view of treatments efficacy and side effect profile and that is for one simple reason:
This, just like every other hair loss forum is mainly frequented by two cathegories of people:
1. People who are worried about their hair loss (usually early stages) but don't take anything yet.
2. People who tried the (in)famous medications but didn't get results either because of inefficacy, or side effects that made them stop.
The ones who simply go to a dermatologist, hook on MIN and/or finasteride and maintain/regrow without problems whatsoever, don't need to spend time on this forum, so their stories will never show here.
If this forum was the real world:
Minoxidil = snake oil.
Finasteride = poison that at 80% gives you sides, permanently in many cases.
P.S.
I'm not a Finasteride supporter, i don't approve how it tackles hair loss, so i don't think i will ever take it, but, nevertheless, IMO this and other forums make it seem much worse than it really is.

 

[Pls_NW-1]

Surfing this forum simply gives you a distorted view of treatments efficacy and side effect profile and that is for one simple reason:
This, just like every other hair loss forum is frequented by two cathegories of people:
1. People who are worried about their hair loss (usually early stages) but don't take anything yet.
2. People who tried the (in)famous medications but didn't get results either because of inefficacy, or side effects that made them stop.
The ones who simply go to a dermatologist, hook on MIN and/or finasteride and maintain/regrow without problems whatsoever, don't need to spend time on this forum, so their stories will never show here.
If this forum was the real world:
Minoxidil = snake oil.
Finasteride = poison that at 80% gives you sides, permanently in many cases.
P.S.
I'm not a Finasteride supporter, i don't approve how it tackles hair loss, so i don't think i will ever take it, but, nevertheless, IMO this and other forums make it seem much worse than it really is.

You frogot the category of people:
Hair=life

 

[Micky_007]

$4.3 million is literally nothing lmao, if that case had any weight or substance at all they would have paid in the hundreds of millions.

The 4.3 million is less then the costs it would take to litigate the case for Merck, yet the class action lawyers still took the money because they knew the case was a shakedown.

Actually no, people were not sueing because they died or because it was life threatening side effects so of course the law suits wouldn't have gone into the hundreds of millions.

 

[trialAcc]

Surfing this forum simply gives you a distorted view of treatments efficacy and side effect profile and that is for one simple reason:
This, just like every other hair loss forum is mainly frequented by two cathegories of people:
1. People who are worried about their hair loss (usually early stages) but don't take anything yet.
2. People who tried the (in)famous medications but didn't get results either because of inefficacy, or side effects that made them stop.
The ones who simply go to a dermatologist, hook on MIN and/or finasteride and maintain/regrow without problems whatsoever, don't need to spend time on this forum, so their stories will never show here.
If this forum was the real world:
Minoxidil = snake oil.
Finasteride = poison that at 80% gives you sides, permanently in many cases.
P.S.
I'm not a Finasteride supporter, i don't approve how it tackles hair loss, so i don't think i will ever take it, but, nevertheless, IMO this and other forums make it seem much worse than it really is.

Exactly this. Confirmation bias at it's finest.

 

[JaneyElizabeth]

You frogot the category of people:
Hair=life

I specifically made sure that no one would contemplate suicide on my thread by changing @bridgeburn's slogan:

https://www.hairlosstalk.com/interact/threads/hair-is-not-life-but-its-pretty-damn-close-hrt-and-pictorial-posts-prove-it.130425/page-23

 

[Pls_NW-1]

I wonder why people complain about side effects, meanwhile you actually decrease a strong androgen systemically in your body lol.

The side effects you experience are actually the effects you want! Don't complain, be happy.

 

[Micky_007]

Surfing this forum simply gives you a distorted view of treatments efficacy and side effect profile and that is for one simple reason:
This, just like every other hair loss forum is mainly frequented by two cathegories of people:
1. People who are worried about their hair loss (usually early stages) but don't take anything yet.
2. People who tried the (in)famous medications but didn't get results either because of inefficacy, or side effects that made them stop.
The ones who simply go to a dermatologist, hook on MIN and/or finasteride and maintain/regrow without problems whatsoever, don't need to spend time on this forum, so their stories will never show here.
If this forum was the real world:
Minoxidil = snake oil.
Finasteride = poison that at 80% gives you sides, permanently in many cases.
P.S.
I'm not a Finasteride supporter, i don't approve how it tackles hair loss, so i don't think i will ever take it, but, nevertheless, IMO this and other forums make it seem much worse than it really is.

Mate, the reason I'm so adamant about my statements against Finasteride is because I myself used Finasteride and experienced side effects. I would not make claims without thoroughly testing it myself.

I was one of the people who experienced sides 2 months in and went onto hair loss forums and the majority of people at the time were all saying side effects aren't really real and it's usually just in people's heads. So I continued the treatment even though it made my hair significantly worse, made me super depressed, lots of anxiety, sexual sides,etc.

But I continued because people on this forum as well told people who experience sides they will subside over time.

I stuck on Finasteride for 1 year and 2 months. Through the brutal sheds and it really destroyed my hair and made my hair so much thinner. I had no positive effect from Finasteride it just made things exponentially worse.

Due to that I ended up with very long side effects.

The mental side effects cleared after about a 3 years after stopping Finasteride. Some people would be like "at least it went away so its nothing to be concerned about", not realizing those are major chunks of peoples lives and can affect peoples lives severely, jobs, relationships, etc.

Some sexual side effects went away after a while but not up until till this very day. This is the reason I tend to advise people to stop Finasteride the moment they first notice side effects.

Sometimes you really gotta think for yourself.

 

[Micky_007]

You have to understand the psychology of it. To these guys, any decrease in T or even DHT is something that they believe will make them impotent. I went impotent at 20 without any meds at all. Baldness can make you impotent and nothing worked until I found polysorbates and then everything started magically working again.

Baldness before 23 (college years) is just staggering in terms of how one approaches women and in its periphery of effects.

I definitely believe such a generalization is wrong. Every person is different, some people are more sensitive to changes in DHT and T and E and can't handle it as well.

 

[Pls_NW-1]

You have to understand the psychology of it. To these guys, any decrease in T or even DHT is something that they believe will make them impotent. I went impotent at 20 without any meds at all. Baldness can make you impotent and nothing worked until I found polysorbates and then everything started magically working again.

Baldness before 23 (college years) is just staggering in terms of how one approaches women and in its periphery of effects.

Ask that the teens suffering of male pattern baldness, like I did! Its just *horrible*.

 

[JaneyElizabeth]

Ask that the teens suffering of male pattern baldness, like I did! Its just *horrible*.

Indeed. There's nothing worse. Acne relents at some point and is associated with youth, not aging like male pattern baldness.

 

[trialAcc]

Actually no, people were not sueing because they died or because it was life threatening side effects so of course the law suits wouldn't have gone into the hundreds of millions.

You honestly don't have a clue what you are talking about. You literally just posted quotes of this drug apparently destroying men's endocrine systems and causing crippling depression. The resulting lawsuit yielded less then the cost of lawyers for the accused? Does that sound like a lawsuit that carried much weight?

 

[JaneyElizabeth]

Lmfao, the tranny gang is coping hard itt.

And I strongly doubt this will be "safe" either.

Some people find usage of that term offensive but eh. I don't care.

 

[Micky_007]

You honestly don't have a clue what you are talking about. You literally just posted quotes of this drug apparently destroying men's endocrine systems and causing crippling depression. The resulting lawsuit yielded less then the cost of lawyers for the accused? Does that sound like a lawsuit that carried much weight?

It was a class action law suit. They did not require 1100 lawyers (a lawyer per person). And yes it does sound like a law suit that carried much weight because if they were wrong, they wouldnt have gotten paid out firstly and secondly it was due to all these opposing studies in the first place that forced* Merck and Finasteride to increase their side effects profile.

I see that as a victory.

 

[JaneyElizabeth]

Janey Elizabeth explained it well. Yes I'm aware they have different MoA however, they all are technically anti-androgens.

Although, I will admit I do not like the turn this thread has taken being a discussion about Finasteride when the thread was intended for Kintors Drugs.

Let us all rather get back to discussing Kintors.

You might get mad at me but the anti-finasteride people and the new experimental drug people have some things in common.

 

[Micky_007]

I simply don't believe that finasteride causes impotence so I discard all of those folks' opinions basically. Some of the other sides, maybe but I think that 4 percent might be the high end. I don't believe that the effects are permanent either. Anti-finasteride people come off terribly on message boards and fora because they all seem to not understand that some of us don't care about their sides even if they happened. It amounts to proselytizing.

Literally the most reported side effect of Finasteride is low libido. Any web site you go to will tell you that, literally even Merck and Finasteride state low libido is a side effect, but since you don't care about the side effects of others then maybe the fact that based on the statement that you claimed in your next comment "Finasteride definitely doesn't cause decreased libido" then maybe your opinions* shouldn't be considered either.

 

[Micky_007]

Also, how I know for a fact Finasteride messed my hair up, is because after I stopped Finasteride, my hair got exponentially better.

 

[frank33]

Also, how I know for a fact Finasteride messed my hair up, is because after I stopped Finasteride for a few months my hair got exponentially better.

I've read a study a while ago that said DHT, in low quantities, promotes hair growth, so maybe DHT is not the cause of your hair loss