The reason why people get results from minoxidil is because it's a VASODILATOR. Nothing more, nothing less. People go off on how it can promote certain things.... Well OF COURSE it can it promotes BLOOD FLOW... Lol. The reason why some people don't see results is because some people (such as sparx for example) have too much of a tight scalp to have it work on them. Their blood flow is severely disrupted by a tight Galea. On the other hand, you may have other people who experience results from almost anything because their Galeas aren't too tight and thus their blood flow isn't as disrupted.
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Number one: Disrupted blood flow leads to all of this... It isn't the other way around, my friend.
Number two: Dermarolling is supposed to regenerate subcutaneous fat and get rid of fibrotic tissue... hence why it works so well.
Number three: Emu oil is an anti-fibrotic oil which also helps replenish subcutaneous fat cells. Check out Dr.Hollicks work.
I also THINK that stimulating the area via increased blood flow regenerates this fatty layer.... The body is extremely resilient and I believe if we reverse this process via addressing the main culprit of things (tight scalp=> disrupted blood flow) that we can accomplish replenishment of these cells. Don't most fat cells have memory anyways?
Disrupted blood to the scalp leads to Male Pattern baldness..??? If I hit your pumpkin with a 2x4.. I bet you gonna bleed like pig. Stop being ridiculous. Baldness is triggered by DHT. Male Pattern baldness is caused by the lack of migration of progenitor cells to the follicles due to the accumulation of collagen and fibrosis induced by DHT. Androgen significantly increases production of collagen which strangle the hair follicles and stop the migration of the stem cell. By dumping minoxidil to your pumpkin ( Nitric Oxide) you facilitate the migration of the progenitor cells to the follicles by vasodilation. It also fight the collagen accumulation.
Effects of minoxidil on cultured human skin fibroblasts.
Pinnell SR, Murad S.
Source
Department of Medicine, Duke University Medical Center, Durham, N.C.
Abstract
Two important findings related to the effect of minoxidil on human skin fibroblasts in culture are reviewed. Treatment of cells with minoxidil is associated with a specific loss of lysyl hydroxylase activity; this loss occurs gradually and is reversed by removing minoxidil from the culture medium. Experiments with inhibitors of protein and RNA synthesis reveal that minoxidil may inhibit the synthesis of lysyl hydroxylase by acting at the transcriptional level. Treatment of cells with minoxidil is also associated with inhibition of proliferation, without any sign of cytotoxicity. This effect of minoxidil is accompanied by inhibition of DNA synthesis. Since collagen is the major product of fibroblast activity and lysyl hydroxylase catalyzes a crucial reaction in collagen biosynthesis,
the combined effects of minoxidil offer the potential for its use as an antifibrotic agent. Thus, minoxidil may prove to be beneficial in treating skin conditions associated with collagen accumulation.
Action of androgen on fibroblast collagen synthesis: a receptor-dependent response.
C Loire[SUP]
1[/SUP], B Kern[SUP]
1[/SUP] and Ch Sultan[SUP]
1[/SUP]
[SUP]1[/SUP]INSERM U.58, MONTPELLIER and CNRS GR.40, CRETEIL, France.
Top of pageAbstract
Several groups are still investigating an "in vitro" biological response of androgen action. The purpose of this study was to determine whether dihydrotestosterone (DHT) influences the secretion of collagen by cultured foreskin fibroblasts raised from patients with normal or undetectable DHT-binding activity (complete androgen resistance). Collagen synthesis and secretion were evaluated by [SUP]3[/SUP]H-proline incorporation in newly synthetized collagen by confluent fibroblasts alone, or in the presence of DHT (10[SUP]−5[/SUP] to -10[SUP]−10[/SUP]M). Production of collagen is expressed as a ratio between tritiated OH-proline and OH-proline plus proline,within the cells or in the culture medium.
These data show that : -in control cells,
DHT significantly increases production of collagen released in the culture medium (p < 0.001), -In complete androgen resistance with no detectable androgen binding activity, DHT does not modify basal collagen synthesis. These results strongly suggest that this hormonal response is mediated via a DHT-receptor or is receptor-dependent. This could be used as a biological response of androgen action in patients with androgen resistance associated with a "post-receptor" defect.
I am still trying to find a free version of their study from L’Oreal.
L’Oreal was bang-on with their study earlier.. which is thought to prevent the build-up of collagen around follicles. “During the hair cycle the follicle has to be rebuilt from stem cells,” explains Dr Bruno Bernard, director of research for life sciences at L’Oreal. “Stem cells in human hair follicles are localised in two different reservoirs – one is in the upper part of the follicle and the other in the lower part. “The cells in the lower part are required to activate the cells in the upper part and so help to maintain the follicle function. The thickening of collagen in the connective tissue sheath, which sits around the base of the hair follicle, prevents the movement of stem cells from the lower reservoir to the upper reservoir. Bit by bit, the follicle is squeezed and causes the follicles to grow smaller and smaller.” Indeed, research from The Rockefeller University in New York suggests movement between the two groups of stem cells is crucial in normal hair growth.
Another recent study, at the University of Pennsylvania, has shown that bald areas of scalp contain the same number of stem cells as hairy areas. It disproved theories that hair loss in androgenic alopecia was due to a loss of follicle stem cells suggesting that they have just become inactive.
Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.
Garza LA,
Yang CC,
Zhao T,
Blatt HB,
Lee M,
He H,
Stanton DC,
Carrasco L,
Spiegel JH,
Tobias JW,
Cotsarelis G.
Source
Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Abstract
Androgenetic alopecia (Androgenetic Alopecia), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from Androgenetic Alopecia individuals for the presence of hair follicle stem and progenitor cells. Cells expressing cytokeratin15 (KRT15), CD200, CD34, and integrin, α6 (ITGA6) were quantitated via flow cytometry. High levels of KRT15 expression correlated with stem cell properties of small cell size and quiescence. These KRT15(hi) stem cells were maintained in bald scalp samples. However, CD200(hi)ITGA6(hi) and CD34(hi) cell populations--which both possessed a progenitor phenotype, in that they localized closely to the stem cell-rich bulge area but were larger and more proliferative than the KRT15(hi) stem cells--were markedly diminished. In functional assays, analogous CD200(hi)Itga6(hi) cells from murine hair follicles were multipotent and generated new hair follicles in skin reconstitution assays. These findings support the notion that a defect in conversion of hair follicle stem cells to progenitor cells plays a role in the pathogenesis of Androgenetic Alopecia.
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then u maybe never were in a gym. I see like 9/10 ppl in the gym who are balding ,are balding on temples only.
also beeing fat leads to more estrogen production since fat cells are producin alot of aromatase. They have quite different hormon specs than low fat ppl
I am in the Military, I am at the gym 6 days a week. Body composition have nothing to do with hairloss. Stop it already with your dumbasses observations and keep it to another threads or for yourself. You misleading people with your stupid personal perception on baldness. There is some relationship with aromatase activity and body fat distribution but has nothing to do with baldness.
... the in vitro study above used an upper bound level of 25ug per ml... since a minoxidil bottle has only 60ml, 2-3 pills (1000ug per pill) would be more than enough, this also reflects how cheap and easy this simple addition is
