New Studies Show Vit D Implicated In Hair Loss And Calcipotriol

[Dontwannabeabetabob]

When I went to a derm for my hair once the lab results came back she called and said I was deficient in Vitamin D. Made sense since I was very depressed and didn't really go outside nor did I eat properly. Never did I think that plays a role in my hair loss, nor do I do now since I'm very skeptical on the subject. I started taking Vit D supplements though now I've stopped. I like to keep an open mind however, maybe it's just a coincidence I lost so much hair so fast. Who knows. Anyways it's interesting, our bodies are so complex.

 

[kennyl370]

Yes, and if you're allergic to peanut butter it will kill you.

But peanut butter is actually a fantastically healthy food overall, just as DHT does awesome things in the body. The issue is flawed sensitivity to peanut butter or DHT.

We need the EpiPen for hairloss. lol

 

[abcdefg]

One word, genes. DHT triggers hair loss, fact, what you're claiming is like saying fire kills trees so just put the fire out with water and expect it to regrow again. The conditions for it to happen just aren't there anymore.

Yeah tell that to all the people that criticize the new users here that post pictures of minor hair loss asking if its male pattern baldness. You have to prevent and risk sides of finasteride very early to try to keep what you have. Showing up here at Norwood 3 the finasteride aint gonna help you much anymore. You have to treat it almost before it gets noticeable, but then doctors wont take it seriously. Its tough to do

 

[mr_robot]

Increased DHT is n't the problem, it is increased local 5aR in the hair follicle that increases in follicle T->DHT conversion. Normal non balding follicles have both T and DHT present but T is halfed and DHT is doubled in balding follicles. Decreasing total serum DHT is a pretty crappy fix to the problem..

Anyhow getting back to the topic, I take 1000ui D3 every day due to low VitD. Cholecalciferol can applied taken topically, I'm going try pure cholecalciferol powder mixed in directly with my topicals and see what happens.

 

[Jk1]

Increased DHT is n't the problem, it is increased local 5aR in the hair follicle that increases in follicle T->DHT conversion. Normal non balding follicles have both T and DHT present but T is halfed and DHT is doubled in balding follicles. Decreasing total serum DHT is a pretty crappy fix to the problem..

Anyhow getting back to the topic, I take 1000ui D3 every day due to low VitD. Cholecalciferol can applied taken topically, I'm going try pure cholecalciferol powder mixed in directly with my topicals and see what happens.

Good idea robot, what do we have to loose by applying vitd or cod liver oil topicaly. Not much low cost low risk and that their is these studies showing faulty vit d receptors in us maybe worth a shot if we all try.

 

[mr_robot]

Good idea robot, what do we have to loose by applying vitd or cod liver oil topicaly. Not much low cost low risk and that their is these studies showing faulty vit d receptors in us maybe worth a shot if we all try.

Well in cases like mine where I also have seborrheic dermatitis that is linked to vitamin D deficiency and can cause hair loss, it is worth the experiment. I should have my powder in a few days.

 

[whoken]

I applied liquid vitamin D on my scalp for the sake of it, as I'm not convinced it will help, well the third day it gave me acne breakout on my scalp. That's weird. Of course I had to stop.

 

[mr_robot]

I applied liquid vitamin D on my scalp for the sake of it, as I'm not convinced it will help, well the third day it gave me acne breakout on my scalp. That's weird. Of course I had to stop.

Don't want to sound rude but was you scalp clean? Also, which liquid vitamin D did you use? After looking at all the ones available I decided to get the pure bulk powder.

 

[whoken]

Don't want to sound rude but was you scalp clean? Also, which liquid vitamin D did you use? After looking at all the ones available I decided to get the pure bulk powder.

Yes, it was clean, I don't have an oily scalp anyway. It's Solgar Liquid Vitamin D3.

 

[mr_robot]

Yes, it was clean, I don't have an oily scalp anyway. It's Solgar Liquid Vitamin D3.

Well maybe you had a reaction to the sunflower oil or "natural" orange flavoring. I doubt the cholecalciferol would cause acne.

 

[Jk1]

How long do u apply it ? The cod liver oil i leave on for 3 to 4 hours then shower off and havent experienced acne. Others who have tried cod liver oil do you notice a warm sensation after applying ?

Some people use cod liver oil for joint pain re athrtitis as it reduces inflammation

 

[baldco]

Cross-referencing a second study
https://www.hairlosstalk.com/intera...eration-in-male-androgenetic-alopecia.106097/

 

[abcdefg]

Except it's not. The majority of the population's hair, on this planet at least, does not produce a negative effect when exposed to androgens.........You have to look past the very first thing you see and use some thought. It's not that simple.

This is true though. Most men over time as they get older their sensitivity increases to the presence of DHT and they lose hair. Most men do lose their hair as they get older. Not very many women. Hormones make perfect sense although I agree its more complicated than just DHT and maybe even testosterone as well.
I think most men if given steroids or large doses of T would start to go bald. Most men and maybe even women are sensitive to androgens to some degree. Its very rare for an old man to have perfect brad pitt/elvis hair but it does exist.

 

[mr_robot]

This is true though. Most men over time as they get older their sensitivity increases to the presence of DHT and they lose hair. Most men do lose their hair as they get older. Not very many women. Hormones make perfect sense although I agree its more complicated than just DHT and maybe even testosterone as well.
I think most men if given steroids or large doses of T would start to go bald. Most men and maybe even women are sensitive to androgens to some degree. Its very rare for an old man to have perfect brad pitt/elvis hair but it does exist.

But the majority of male pattern baldness cases are n't due to increased T serum levels and we know that T levels reduce as men get older. Follicles do not suddenly become more sensitive to androgens and cause hair loss, if that was the case then T/DHT ratio in balding hair follicles would be exactly the same as non balding but they are not as they become skewed towards DHT via increased local 5ar. DHT being a 3-5x more potent androgen is the issue here and the increase of 5ar produced in the follicle is the culprit. What is causing the increase in 5ar production? That is the question that should be being asked rather than concentrating on DHT/AR as these are simply symptoms.

 

[abcdefg]

If someone regrows all their hair or even stops male pattern baldness for years just with vitamin D can they post some pictures of that? I dont buy into the idea of vitamin D like levels of that in your body causing male pattern baldness. If you are outside 15 minutes that is enough time for body to convert into vitamin D its not like you have to sit outside for 7 hours or something. Vitamin D and most vitamins are in lots of foods it would be hard to be deficient in that to the point of causing male pattern baldness.

 

[IvanXproject]

What about vitamin D3 injections to the scalp? Maybe that could do something

 

[resu]

Let's congregate all the studies about the role of VDR.

"Role of Vitamin D receptor in adult hair follicle cycling"

Among the large number of molecules playing a role in the control of this oscillator system, one of the most interesting is the vitamin D receptor (VDR). Lack or alteration of VDR in both human and mouse lead to an absence of adult hair follicle cycling, with a defect in anagen re-initiation.

http://www.fasebj.org/cgi/content/meeting_abstract/20/5/A1079-a

--

"Does D matter? The role of vitamin D in hair disorders and hair follicle cycling."

RESULTS:

The vitamin D receptor, independent of vitamin D, plays an important role in hair cycling, specifically anagen initiation. The role of vitamin D in hair follicle cycling is not as well understood.

https://www.ncbi.nlm.nih.gov/pubmed/20178699

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"ROLE OF THE VITAMIN D RECEPTOR IN HAIR FOLLICLE BIOLOGY"

These studies demonstrate that absence of the VDR leads to the development of alopecia. The hair follicle is formed by reciprocal interactions between an epidermal placode, which gives rise to the hair follicle keratinocytes and the underlying mesoderm which gives rise to the dermal papilla. Hair follicle morphogenesis ends the second week of life in mice. Studies in VDR null mice have failed to demonstrate a cutaneous abnormality during this period of hair follicle morphogenesis. However, VDR null mice are unable to initiate a new hair cycle after the period of morphogenesis is complete, therefore, do not grow new hair.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876678/

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"Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth"

Results
Phenotypic abnormalities of VDRKO mice
Homozygous VDRKO mice showed normal growth after birth until 3 wk. After 3 wk, the VDRKO mice showed modest growth retardation and developed rickets. The skin and hair appeared grossly normal after birth until about 3 mo, although some animals showed noticeable hair loss by 6 wk. After 3 mo, the VDRKO mouse showed progressive alopecia, which led to nearly total hair loss by 8 mo (Figure 1); however, no overt abnormalities were found in the heterozygotes (data not shown).

http://www.sciencedirect.com/science/article/pii/S0022202X15415246

 

[IvanXproject]

So those with male pattern baldness have fewer Vit D receptors on the scalp, correct?

 

[Medina]

So those with male pattern baldness have fewer Vit D receptors on the scalp, correct?

It would appear so.

And guess what increases those receptors?
Estradiol, Prostaglandins, Curcumin, Linolenic acid, Lithocholic acid, Fish oil omega-3 (All kinds of sh*t we've seen before)

And guess what inhibits the receptor?
Thyroid hormones, cortisol, prolactin (Again, all kinds of sh*t we've heard about before)

So maybe there is a connection, maybe DHT blocks VDR in the scalp? I don't know. Again, bro science.

 

[Grasshüpfer]

Best Thread this year probably.

So maybe there is a connection, maybe DHT blocks VDR in the scalp? I don't know. Again, bro science.

We know that eventually it's really dht directly causing the cells to go senescent.

We also know from the genome wide association study that the vdr is closely related to baldness. So maybe it's the other way round: The vdr messes with the Ar.

We also speculated already here that male pattern baldness could be an adjustment to the few hours of sun in northern regions.

What few people know is that in North of Europe the sun is only for a few hours a day capable of inducing vit D synthesis.

Also the whole north of Europe, different from the savannah, was covered almost entirely in dense forest, so that sunlight would enter at a steep angle unfit to hit the exposed face and hands, but only shining on clothing and hair.

So male pattern baldness could be an evolutionary adjustment.

 

[Grasshüpfer]

I was right:

The production of sex hormones is regulated by multiple enzymes. Vitamin D has been reported to affect the expression and activity of several of these enzymes.

17β-hydroxysteroiddehydrogenases. Wang and Tuohimaa62 have reported that 1α,25-dihydroxyvitamin D3 upregulates the mRNA level for 17β-hydroxysteroid dehydrogenases (17β-HSD) type 2, 4 and 5 in cell lines derived from human prostate. In keratinocytes, Hughes et al.63 have reported that 1α,25-dihydroxyvitamin D3stimulates the expression of 17β-HSD type 1 and 2.

Aromatase. It has been shown that 1α,25-dihydroxyvitamin D3 alters the aromatase activity in placental cells64,65, prostate cells66 and osteoblasts67,68. Kinuta et al.69have reported that vitamin D receptor null mutant mice have a decreased aromatase activity in the ovary, testis and epididymis.


https://f1000research.com/articles/3-155/v1


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