New Studies Show Vit D Implicated In Hair Loss And Calcipotriol

[Min0]

baldness exists all over the world, even in some primates, this sun adaptation theory is unlikely.
also females need more vit D because they generate another skeleton when they're pregnant. you don't see them losing hair.

 

[Medina]

https://www.ncbi.nlm.nih.gov/pubmed/20592360

CONCLUSION:
The inverse correlation between VDR and both COX-2 and 15-PGDH, as well as between PGE2 and 25(OH)(2)D(3) levels, suggests a possible link between VDR-associated target genes and prostaglandin metabolism.

I keep thinking of that prostaglandin thing from a while ago, I seem to remember they got the best results after adding UV light.

 

[Medina]

View attachment 54734

baldness exists all over the world, even in some primates, this sun adaptation theory is unlikely.
also females need more vit D because they generate another skeleton when they're pregnant. you don't see them losing hair.

I don't believe in the sun adaption theory either, many black dudes are bald. But the issue isn't Vitamin D. The issue is the receptors. Maybe scalp tissue starts to change the way it metabolizes VD and without the protection of estrodiol (like women have) the hair cycle gets fucked. Which causes inflammation and the rise of bad prostaglandins.

There needs to be a scientific study on the relationship between VD/VDR and DHT.

 

[Jk1]

View attachment 54734

baldness exists all over the world, even in some primates, this sun adaptation theory is unlikely.
also females need more vit D because they generate another skeleton when they're pregnant. you don't see them losing hair.

And yes baldness exists all over the world because people work indoors all over the world Some do and some don't so their will always be this difference.. OR even old primates loose VIT d receptors with age. Where i look is to see which people are often outside often and who is inside most often. Homeless people often have very strong hair... they can still have some recession it seems. Compared to office people who spend most time indoors. if you are behind glass you will get zero vit D. worst case scenario is night shift workers .. and look at their risk of hairloss or cancers due to low VIT D https://www.ncbi.nlm.nih.gov/pubmed/15930183

The reason why womens hair gets better during pregnancy is due to estrogen increase.

And in this study here Estrogen binds to and boosts Vitamin D receptor.
https://www.ncbi.nlm.nih.gov/pubmed/15930183

 

[mr_robot]

https://www.ncbi.nlm.nih.gov/pubmed/20592360

CONCLUSION:
The inverse correlation between VDR and both COX-2 and 15-PGDH, as well as between PGE2 and 25(OH)(2)D(3) levels, suggests a possible link between VDR-associated target genes and prostaglandin metabolism.

I keep thinking of that prostaglandin thing from a while ago, I seem to remember they got the best results after adding UV light.

UV light is basically wounding the skin, completely different method of action.

I don't believe in the sun adaption theory either, many black dudes are bald. But the issue isn't Vitamin D. The issue is the receptors. Maybe scalp tissue starts to change the way it metabolizes VD and without the protection of estrodiol (like women have) the hair cycle gets fucked. Which causes inflammation and the rise of bad prostaglandins.

There needs to be a scientific study on the relationship between VD/VDR and DHT.

A large percentage of black males have European ancestry due to slaves being ****ed by their owners. If you look at tribes in southern Africa they don't go bald.

VDR and DHT would be pointless, what you want is VDR and 5aR or better still the enzymes that are responsible for its production.

 

[Medina]

UV light is basically wounding the skin, completely different method of action.



A large percentage of black males have European ancestry due to slaves being ****ed by their owners. If you look at tribes in southern Africa they don't go bald.

VDR and DHT would be pointless, what you want is VDR and 5aR or better still the enzymes that are responsible for its production.

African leaders and statesmen

 

[Jk1]

I don't believe in the sun adaption theory either, many black dudes are bald. But the issue isn't Vitamin D. The issue is the receptors. Maybe scalp tissue starts to change the way it metabolizes VD and without the protection of estrodiol (like women have) the hair cycle gets fucked. Which causes inflammation and the rise of bad prostaglandins.
Thy ere needs to be a scientific study on the relationship between VD/VDR and DHT.

Agree with most of this, but its not realy black or white guy thing.

One issue is this genetic difference in VIT D receptors makeing some more people more susceptible to low vit D as they are starting off with a VDR receptor handicap on scalp hair growth.

The other issue is , is your skin colour adapted to the coutry you live in and the sun hours of your day schedule.
Black people in their natural environment can have very thick hair, if you see african affros or Aboriginal Australians had little hairloss if you look at photos. But these same people in the modern day liveing in suburbia indoors seem to have a lot more hairloss.

Regarding the VDR receptor, yes for me its also cannot be by random luck . its an evolutionary safety mechanism, that the spot on the body that has the most sun exposure the top of the head, is also the first place that male pattern baldness starts. their must be some feedback mechanism, maybe on the scalp their is the most VIT D receptors when you are born, but then over time due to lack of VIT d or sun scalp or DHT , this is the first place that hairloss starts. i.e the most sensitive place to sun exposure to counteract the low sun exposure. if you look at underground mammals they have the least hair or no hair i.e the naked mole rat.

 

[mr_robot]

African leaders and statesmen

I said tribes, there is another thread specifically about this in this section.

 

[Medina]

I said tribes, there is another thread specifically about this in this section.

Not sure how this is relevant?

And my point about the UV light is he may have accidentally interfered with VDR. But who knows.

 

[Jk1]

African leaders and statesmen

View attachment 54737

View attachment 54738

MEdina photos of some old black guys with male pattern baldness does not surprise me. with old AGE VIT D receptors drop, black people have some of the lowest VIT d in the USA. What does surprise me today is photos of young white guys at 18 YO with male pattern baldness. I.e early ONSET male pattern baldness is the main issue today. in the past i think it occured a lot later and less often. And this matches with our more indoor lifestyle, glass that blocks UV and low VIT D.
But seems to be luck of the draw if you have the VDR genetic variation of low expression where it matters only.

 

[mr_robot]

Not sure how this is relevant?

And my point about the UV light is he may have accidentally interfered with VDR. But who knows.

There are a few tribes in south Africa that have no interbreeding with outside populations. These people have the most diverse DNA yet no male pattern baldness.

 

[Medina]

Ok it doesn't explain that our cousin primates go bald but let's stay on topic guys.

Wasn't that prostoglandin guy was on dutaseride? Maybe it took care of the hormones internally and took care of the VDR problem externally. The conditions of his scalp would almost be like that of a woman. Especially with the raised estrogen? I dunno

 

[Min0]

didn't want to make a new thread for this theory.
Gravity and Baldness : http://www.beIgraviacentre.com/blog/is-gravity-responsible-for-baldness/

does anyone have information on which primates have male pattern baldness ? if it's only the erect ones then we might be into something here.

 

[Medina]

didn't want to make a new thread for this theory.
Gravity and Baldness : http://www.beIgraviacentre.com/blog/is-gravity-responsible-for-baldness/

does anyone have information on which primates have male pattern baldness ? if it's only the erect ones then we might be into something here.

I don't believe in that theory at all I'm afraid, again, what about the women? And no, it's not only "erect ones", macaques also

 

[abcdefg]

How exactly do you change VDR levels to make any practical use of this? There is nothing you can do with this info yourself. It has nothing to do with vitamin D itself.

 

[IvanXproject]

How exactly do you change VDR levels to make any practical use of this? There is nothing you can do with this info yourself. It has nothing to do with vitamin D itself.

Estrogen increases VDR count, but it would have been nice if there was something else too (without side effects)

 

[Medina]

Below is a list that increases Calcitrol and VDR Gene Expression. I'm not f*****g smart enough to understand half of this sh*t but the whole VDR thing is exciting to me because it may answers questions like: Why would a 50 year old man who had DHT his whole begin the balding process? Especially as hormones are supposed to decrease with age. Guess what else decreases with age? Motherfucking VDR.

• RXR (and retinol) is needed to produce proteins with the VDR (R). 1,25D3 binds to the VDR, which then combines with RXR to activate gene expression. (Not all VDR dependent genes need RXR.)
• Parathyroid hormone (PTH) – increases Calcitriol/1,25 D3 (R) and PTH -related peptide (R),
• SIRT1 -potentiates VDR (R, R2) – acetylation of VDR lessens 1,25D/VDR signaling. SIRT1 increased the ability of VDR to associate with RXR.
• PGC-1a (R) – potentiates VDR. It is a coactivator of the VDR, but it still needs 1,25D3.
• Dopamine (R)
• Bile – specifically Lithocholic acid or LCA (R),
  The VDR evolved from its ancient role as a detoxification nuclear receptor. LCA is produced from the gut bacteria (metabolizing liver derived chenodeoxycholic acid). LCA travels to the colon, where the VDR binds to LCA or 1,25 D and activates the CYP3A4 and SULT2A genes facilitates disposal from the cell via the ABC efflux transporter (R).
• Omega-3: DHA, EPA (R), – Fish oil/DHA
• Omega-6: Linolenic acid, Arachidonic acid (R),
• Curcumin (R) – Curcumin is more active than LCA/Bile in driving VDR-mediated
  transcription and that it binds to VDR with approximately the same affinity as LCA.
• Resveratrol (R) – Potentiates VDR by: (1) potentiating 1,25D binding to VDR; (2) activating RXR; (3) stimulating SIRT1.
• Forskolin (R), – increases 1,25D3 from 25D3 in-vitro.
• Gamma Tocotrienol (R)- Tocotrienols or Tocopherols (IHERB)
• Vitamin E/alpha-tocopherol (R)- doesn’t compete with calcitriol for the VDR.
• Dexamethasone (R) – doesn’t compete with 1,25
• Interferon gamma -IFN-γ treatment inhibited 1,25D3 induction of 24-hydroxylase, the enzyme that breaks down 1,25 D3. This means 1,25D3 increased. (Technical: IFNy did not change the base level activity of the promoter, or change 1,25D binding to the VDR or nuclear VDR levels. IFN-γ impairs VDR-RXR binding to VDRE through a Stat1-mediated mechanism) (R),
• Estradiol increases VDR expression (R, R2) and calcitriol levels (R).
• Phytoestrogens (R),
• Testosterone (R),
• Prostaglandins (R),
• Bisphosphonates (R),

 

[Medina]

Here's a question, I wonder if men and women have the SAME amount of androgen and estrogen receptors?

It's interesting how women age, they grow a light moustache, or get thin hair. So the answer to this question would probably be yes.
But estrogen is fighting this sh*t for them? Obviously estrogen isn't helping us. DHT is winning the battle in the scalp. But why?

It's enough to want to shoot yourself.

SOMETHING MUST BE PROTECTING THESE MEN AND WOMEN WHO DON'T LOSE HAIR. Or at least don't lose hair for decades.

Is this great protector the vitamin D receptor?

(Sorry for the rant)

 

[Medina]

It doesn't make any sense because of beards.

If VDR was so important for hair growth, men must have sh*t tons of it (in the face, on the chest, the arms, legs) Yet balding guys are somehow Vit D deficient? Unless that's the reason baldness happens... to get more vitamin D to places that need it.

 

[resu]

It doesn't make any sense because of beards.

If VDR was so important for hair growth, men must have sh*t tons of it (in the face, on the chest, the arms, legs) Yet balding guys are somehow Vit D deficient? Unless that's the reason baldness happens... to get more vitamin D to places that need it.

It's not about Vitamin D levels, it's the VDR, we have less active ones in our scalps according to the study.

The follicles are triggered by our genes to be start miniaturizing, some right at puberty, others later in life or all NW5 and more at once.