not really male pattern baldness but interesting - arthritis treatment cures alopecia

JZA70

JZA70

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IDW2BB

IDW2BB

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http://www.ncbi.nlm.nih.gov/pubmed/24979347

Severe androgenetic alopecia as a proxy of metabolic syndrome in male psoriatic patients older than 59 years.

Descamps V1, Mahé E2, Maccari F3, Begon E4, Barthelemy H5, Reguiai Z6, Bénéton N7, Estève E8, Chaby G9, Ruer-Mulard M10, Steiner HG11, Thomas-Beaulieu D12, Avenel-Audran M13, Goujon-Henry C14, Sigal ML2, Ezzedine K15, Beauchet A16.


Abstract

Background: Whereas several studies have underlined the association between severe psoriasis and metabolic syndrome (MetS), the association of androgenetic alopecia (Androgenetic Alopecia) and MetS have yielded inconsistent results. Objective: To investigate the relationship between Androgenetic Alopecia and the components of MetS in a population of psoriatic male patients. Methods: A non-interventional, cross-sectional, multicenter study was conducted in France. A standardized questionnaire was completed, including information on components of MetS and other possible risk factors. MetS was defined in this study as a combination of three or more of the four components of MetS: waist circumference, hyperlipidemia, diabetes mellitus and hypertension. In addition, a standardized simplified Norwood classification limited into 5 grades (0-4) was used. Results: In a total of 1073 male patients, hypertension, high waist circumference, diabetes mellitus and hyperlipidemia were observed in 28%, 59%, 11%, and 31%, respectively. In age-adjusted multivariate analysis, severe Androgenetic Alopecia (grade 3-4 versus grade 0) was associated with the presence of at least one component of MetS. By groups of age, a statistically significant association of severe Androgenetic Alopecia and MetS was demonstrated in patients over 59 years. Severe Androgenetic Alopecia was also associated with a first degree familial history of major cardiovascular event in patients older than 59 years. Conclusions: Our study, based on a simplified but stringent definition of MetS, confirmed the link between severe Androgenetic Alopecia and individual components of MetS in psoriatic patients. This argues for careful follow-up with regular screening in male psoriatic patients with severe Androgenetic Alopecia in order to early detect determinants of MetS.
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uncomfortable man

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Well how else are the devils going to keep us in purgatory unless they rile us up from time to time?
 
hellouser

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Here's some more info on arthritis drugs having some potential on hair loss reversal:

http://www.hairsite.com/hair-loss/forum_entry-id-85302.html
[url]http://www.hairlosstalk.com/interact/showthread.php/81010-Taiwan-University-Hospital-Human-Clinical-Trials

[/URL]And a really old thread from 2011 posted by the late Squeegee:

http://www.hairlosstalk.com/interac...ale-pattern-baldness-hypertrichosis-and-accel

Notice that benoxaprofen was used. Perhaps if turned into a topical it could lead to some results?
 
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bald29

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Python said:
You're very late to the party, this has been discussed ready. We are just waiting on someone to take the plunge with the drug. Maybe we can get a homeless guy to try it?
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I volunteer :p Where do I sign?
 
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bald29 said:
I volunteer :p Where do I sign?
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Okay, what is your current regimen, hair status. We will set you up as a control patient. Then we will deal with the protocol, people will have to donate for the cost.
 
uncomfortable man

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Roll those dice like there hot!
 
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Python

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Someone get on this sh!t already. This can be the cure but we need more attention on it. How hard is it to make an ****!ng cream for localized treatment
 
hellouser

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Python said:
Someone get on this sh!t already. This can be the cure but we need more attention on it. How hard is it to make an ****!ng cream for localized treatment
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No need to turn it into a 'cream' its molecular weight is pretty damn small so it'll pass through skin fairly easily. It's actually smaller than RU.

Don't worry... someone will be trialing it soon ;)
 
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hellouser said:
No need to turn it into a 'cream' its molecular weight is pretty damn small so it'll pass through skin fairly easily. It's actually smaller than RU.

Don't worry... someone will be trialing it soon ;)
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Do you know where I can get it cheap? I'm willing to try it, dilute it in water then filter and maybe in alcohol?
 
hellouser

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Python said:
Do you know where I can get it cheap? I'm willing to try it, dilute it in water then filter and maybe in alcohol?
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There's no 'cheap' option, the stuff is ridiculously expensive; 25k/year.

However, it is a Janus Kinase inhibitor and there are other drugs that work similarly:

Azulfidine (or Salazopyrin/Sulazine in Europe/Hong Kong)
http://en.wikipedia.org/wiki/Sulfasalazine

It's pretty inexpensive, about 15 bucks for 60 tablets at 500mg per tablet. Give it a go in topical form with Everclear/PG and report back. I think 500mg in 1-2ml may be overkill for a topical solution application, so perhaps try crushing the pill into 5ml of everclear/pg for a 100mg application per 1ml.
 
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bald29

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hellouser said:
There's no 'cheap' option, the stuff is ridiculously expensive; 25k/year.

However, it is a Janus Kinase inhibitor and there are other drugs that work similarly:

Azulfidine (or Salazopyrin/Sulazine in Europe/Hong Kong)
http://en.wikipedia.org/wiki/Sulfasalazine

It's pretty inexpensive, about 15 bucks for 60 tablets at 500mg per tablet. Give it a go in topical form with Everclear/PG and report back. I think 500mg in 1-2ml may be overkill for a topical solution application, so perhaps try crushing the pill into 5ml of everclear/pg for a 100mg application per 1ml.
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It doesn't sound like a bad plan, but what makes you think that 100mg would work? Why not more? Or less?
 
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Python

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bald29 said:
It doesn't sound like a bad plan, but what makes you think that 100mg would work? Why not more? Or less?
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I would think the best dosage would be the one the guy got daily. Do you know what dosage it is usually given in?

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hellouser said:
There's no 'cheap' option, the stuff is ridiculously expensive; 25k/year.

However, it is a Janus Kinase inhibitor and there are other drugs that work similarly:

Azulfidine (or Salazopyrin/Sulazine in Europe/Hong Kong)
http://en.wikipedia.org/wiki/Sulfasalazine

It's pretty inexpensive, about 15 bucks for 60 tablets at 500mg per tablet. Give it a go in topical form with Everclear/PG and report back. I think 500mg in 1-2ml may be overkill for a topical solution application, so perhaps try crushing the pill into 5ml of everclear/pg for a 100mg application per 1ml.
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Okay, I will see if I can find an online site that sells them, or do you have a reputable one in mind? Despite having heard of PG an everclear, you wouldn't know if it's for sell on California? As I have heard many times on that huge RU thread that it's not legal in some places. Will research though.

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Also, I would assume a topical form would be less harmful?
 
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Python

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Man... the one site I used to but from now requires prescription for this crap. I wouldn't know if the doctor would let me get a prescription for something experimental like this. Anyone know where I can buy it without prescription? Or how can this even be done.
 
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bald29

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Python said:
Man... the one site I used to but from now requires prescription for this crap. I wouldn't know if the doctor would let me get a prescription for something experimental like this. Anyone know where I can buy it without prescription? Or how can this even be done.
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It might be a bit risky for your health to do that experiment on your own... Maybe you can find a doctor and work together on this. These drugs have multiple side effects, and we also don't know what would happen if they enter the scalp directly, as they are supposed to be taken orally.

Notice that on the original experiment there was a team of physicians involved, who did constant tests on the patient to make sure everything was OK.
 
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