If you're extracting anything and you're not using heat, you're going to want to leave it for at least a few days. Use ethanol. Forskolin is aliphatic and has a ton of hydroxyl groups, so ethanol should work well. DMSO will work well, too, but if you're going to be putting this on your skin, I don't think you'll need that much DMSO. I would advise using ethanol and then adding DMSO later to act as a penetration enhancer if you want to use DMSO. Either way will work, though.. just skip the water.
I'm curious to see how it affects you. Use of compounds to upregulate aromatase and cAMP are things that I've researched the past couple years. The only one I tried was PGE2, which was definitely a success, but not complete without dealing with the 5AR issue. I was thinking of purchasing dibutyryl-cAMP to see what effects it might have, but never did.
I am curious myself.
DHT inferior? No way. DHT is the king hormone. It is needed for a host of functions.
I didn't say it wasn't needed. There's no such thing as a "king hormone". Every hormone serves a physiological purpose and I believe have DHT in the skin is inferior to having testosterone in the skin. More specifically, over expressing 5AR in the skin and hair follicle is inferior. DHT is definitely needed. In fact, I think it's probably most important as a neurosteroid. There's no doubt it's important in sexual function, too. Without it, estrogenic activity goes unregulated and out of control. But it's definitely inferior to have in the skin and hair follicles.
DHT is highly neuroactive and seems to also be critical for mucosal tissue function (mouth, gut/digestive tissues) as well as vascular tissue. It's an absolute necessity for physical performance due to the vascular effects and neurological effects. It gives you this electric feeling almost.. you wouldn't really recognize it unless you've lost it from taking finasteride, though.
You probably don't have much 5AR expression in certain areas of the body and likewise you may have lower aromatase expression in those areas too. So, suppression of 5AR activity doesn't have much effect in those areas. Or finasteride is perhaps not as effective in you. Finasteride is extremely potent for me even at microdoses and I get all of the worst side effects from it.
They responded well to finasteride because it put them in an androgen deprived state. The effect finasteride has on HPTA regulation of steroid synthesis is what would cause a hairy person to become less hairy. For me, it causes my body hair to increase in thickness and darkness for a short time and later it ends up thinner and less dense after finasteride has done it's metabolic damage and caused HPTA dysregulation.
The only way to avoid losing effectiveness is to cycle finasteride.. Give yourself breaks where you let you 5AR expression return to complete normal and start again. Long term, it's just a really shitty way to deal with hair loss because it helps with DHT while simultaneously ruining your body's ability to provide what hair needs to be healthy. For healthy functioning hair follicles, you need high aromatase expression within the follicle and a good supply of testosterone. Finasteride will ruin both of those eventually.
