Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)

[byebyehair]

Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.

Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg

Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)

- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week

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View attachment 164864

That regrowth looks really good. Did you note any side effects, starting smi?

 

[Photon]

That regrowth looks really good. Did you note any side effects, starting smi?

Not really. Some people claimed vivid dreams but I didn't notice.

 

[Chads don't bald]

Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.

Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg

Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)

- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week

View attachment 164863

View attachment 164864

You take metformin, rapamycin, and fisetin + querecetin for anti aging?

 

[Photon]

You take metformin, rapamycin, and fisetin + querecetin for anti aging?

Yup, along with Hyaluronic Acid, Pure Apigenin, Niacin, and Pure TMG. They're meant to boost NAD.

 

[French]

What about your shedding since your start of SMI ?

 

[Chads don't bald]

Yup, along with Hyaluronic Acid, Pure Apigenin and Pure TMG. They're meant to boost NAD.

Why not just take NMN in that case?

 

[Dimitri001]

Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.

Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 30mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg

Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 30mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)

- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week

View attachment 164863

View attachment 164864

How long have you been on SMI for?

 

[pegasus2]

Why not just take NMN in that case?

Why does everybody take NMN when it has to be converted to NR before it can be absorbed?

 

[Chads don't bald]

Why does everybody take NMN when it has to be converted to NR before it can be absorbed?

I don't think this has been proven. SLC12A8 is expressed in humans and it can transport NMN across the cell membrane. NMN is the direct precursor to NAD+ so it would be more efficient than NR

 

[pegasus2]

I don't think this has been proven. SLC12A8 is expressed in humans and it can transport NMN across the cell membrane. NMN is the direct precursor to NAD+ so it would be more efficient than NR

NAD and NMN must first undergo extracellular degradation to nicotinamide, nicotinic acid, or nicotinamide riboside in order to be taken up into cells (Felici et al., 2013; Ratajczak et al., 2016

This would make NR more efficient, and it's also cheaper.

Chris Masterjohn, Phd, on the Peter Attia podcast, agrees that oral NMN is a waste, and at best just gets turned into NR:

"I would bet money that oral NMN is not absorbed intact, and that’s because NMN has a charged phosphate group on it, and generally charged phosphates cannot cross cells, and so they are hydrolyzed. And even if it were true that there were transporters in the intestine that could take up NMN intact, it probably still would not be absorbed intact because the phosphatases in the small intestine cleave the phosphates off of everything that you are eat non-specifically, because generally phosphates can’t cross cells. So I doubt that the NMN gets in there intact, and if anything maybe it gets cleaved to NR, and the NR does. I believe the NR gets there intact because that’s what the Rabinowitz group’s paper showed."

NMN v. NR -- Which Is More Effective?

NR and NMN are chemically very similar, but they don't cost the same, and some studies show diifferent effects

www.right-of-assembly.org

 

[byebyehair]

It was about 10 days in that I noticed reduced shedding. 4 weeks now and I'm noticing some regrowth starting to occur

Any further progress

 

[Photon]

What about your shedding since your start of SMI ?

I didn't notice major shedding.

 

[Photon]

Why not just take NMN in that case?

NMN might be something I take in the future. I took NR for a few months and didn't notice any difference. I then read that it might be better to boost NAD with some of the stuff I'm taking if you're a bit younger.

My understanding is that once you reach 35, your NAD levels drop dramatically, so that's when NMN and NR are a better option. I'm not that far from 35, so I may consider it in the future. It's expensive af though. I buy from donotage website.

 

[Photon]

How long have you been on SMI for?

A little over three weeks.

 

[Chads don't bald]

This would make NR more efficient, and it's also cheaper.

NMN v. NR -- Which Is More Effective?

NR and NMN are chemically very similar, but they don't cost the same, and some studies show diifferent effects

www.right-of-assembly.org

Right I know that, but I was saying that it hasn't been proven NR is more effective as there are pathways for NMN to enter cells directly: https://www.nature.com/articles/s42255-018-0009-4#change-history

That being said, I don't really have a dog in this fight. I don't take either NR or NMN as I'm too young for it to do anything. If there are human clinical trials showing which one is more effective then I would be interested, otherwise it's just speculation. NR is cheaper and more stable so it's probably the safer choice to go with as of now.

 

[Nsas]

Before I post my progress, I want to mention that I switched from finasteride to dutasteride, and from topical minoxidil to oral around 6 months ago. So any regrowth could be due to dutasteride and minoxidil, but personally I think it's SMI doing some of the work. Also, I have DUPA, most of the improvement I've seen has been on the top and back of my head, a little on the sides but there's a noticeable improvement imo.

Regimen:
Daily
Morning:
- Sulforaphane
- Vitamin D3
- Qualia (only weekdays)
- Pure Hyaluronic Acid
- Pure Apigenin
- Pure TMG
- Niacin
- Oral SMI 60mg
- Fisetin & Quercetin (only last week of the month)
- Oral minoxidil 2.5mg
- Krill Oil 1k mg

Night:
- Biotin
- ksm-66 Ashwagandha
- Oral SMI 60mg
- Oral minoxidil 2.5mg
- dutasteride 1mg
- Metformin 1kmg (3 times a week)

- Rapamycin 10 mg once a week
- Dermanator 2, 1.5mm every two weeks
- Keto shampoo, three times a week

View attachment 164863

View attachment 164864

when you take oral SMI, do you take it by itself without mixing it with anything? also, how are you measuring it? i bought a scale off amazon, but it's completely useless.

 

[pegasus2]

Right I know that, but I was saying that it hasn't been proven NR is more effective as there are pathways for NMN to enter cells directly: https://www.nature.com/articles/s42255-018-0009-4#change-history

Ok, but the study I just posted contradicts that. "NMN must first undergo extracellular degradation to nicotinamide, nicotinic acid, or nicotinamide riboside in order to be taken up into cells". I don't understand how you say you know that and then you go on to say the opposite. Perhaps you missed that part. Maybe this is not accurate, but if it is then NMN is not nearly as good as NR so you'd be taking a big risk taking NMN whereas you know NR works. Further studies have to be conducted on humans to determine which of these studies is correct. What we can say for sure is that NR works, so I see no reason to risk taking NMN instead. Even in best case scenario it won't work much better since NR is very good at converting to NAD. As of now there are more studies showing that NR works in humans than NMN. This could change, and NMN could be slightly better. I assume NMM popularity comes from David Sinclair, but even he admits that NR might be better, they need more study to find out. For now I will stick with the more stable molecule.

 

[Will Be an Egg in 5 years]

Where did the Bayer thread go?

 

[Nsas]

We are dissolving it in PEG400 and in my case 10% DMSO also to dissolve 60mg/ml. Some people put that under the tongue. I put it in a gelatin capsule and swallow it.

Hi. Can you please direct me to where you’re ordering the 10% DMSO from? I’m only able to find pure or near pure DMSO. I know you mentioned in another post that you’re seeing decreased shedding. Are you experiencing regrowth yet?

 

[Chads don't bald]

Ok, but the study I just posted contradicts that. "NMN must first undergo extracellular degradation to nicotinamide, nicotinic acid, or nicotinamide riboside in order to be taken up into cells". I don't understand how you say you know that and then you go on to say the opposite. Perhaps you missed that part. Maybe this is not accurate, but if it is then NMN is not nearly as good as NR so you'd be taking a big risk taking NMN whereas you know NR works. Further studies have to be conducted on humans to determine which of these studies is correct. What we can say for sure is that NR works, so I see no reason to risk taking NMN instead. Even in best case scenario it won't work much better since NR is very good at converting to NAD. As of now there are more studies showing that NR works in humans than NMN. This could change, and NMN could be slightly better. I assume NMM popularity comes from David Sinclair, but even he admits that NR might be better, they need more study to find out. For now I will stick with the more stable molecule.

Yes I agree with you that for right now taking NR is the smart move.

I was just mentioning that there is another pathway for NMN to enter the cell where it doesn't have to convert to NR first.

So if that pathway is indeed present in humans, then it would be more efficient than NR. That's why there needs to be actual human studies comparing NR vs NMN head to head in humans.

Also there is the factor of bioavailibility, I believe NR has lower bioavailibility than NMN. That doesn't necessarily make it worse than NMN though if NMN has to convert to NR first.

All that being said though, I don't think NR or NMN have that much of an effect in humans as it does in mice. Are there any studies which show significant age reversal in humans with NAD+ boosters?