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thanks
Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)
- Thread starter FollicleGuardian
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SMI or not, this is amazing regrow in such a small period
bluesuedeshoes
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Curious to know how much the SMI cost. If any of you are in the discord group and have an invite please DM me. I need some hair for this supposed sl*t summer.
thatguydrinksbeer
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Not sure if it's already been said in this thread, but it appears orgasms cause a prolactin rush. I always thought the anti-fap crowd was nutty, but maybe there's a nugget of truth to it.
Not only after orgasm but during sexual activity as well. I believe edging to be very bad for hair, but the effect of moderate sexual activity to be negligible.
Prolactin concentrations increased (P < .05) immediately after SS[sexual stimulation] and SSE[sexual stimulation + ejaculation] and tended to rise during control bleedings in stallions previously exposed to SS or SSE. We conclude that 1) prolactin and Cortisol were secreted rapidly in response to SS and SSE, 2) the rise in Cortisol concentrations likely suppressed testosterone secretion within the next hour, and 3) stallions appeared to associate the distant sounds of other stallions with their own previous exposure to SS and SSE, resulting in a Cortisol response (and perhaps a prolactin response) even in the absence of direct stimulation.
Effects of Sexual Stimulation, with and without Ejaculation, on Serum Concentrations of LH, FSH, Testosterone, Cortisol and Prolactin in Stallions
Abstract. Six lighthorse stallions with previous sexual experience were used to determine the short-term effects of sexual stimulation (SS; 5 min exposure to an
academic.oup.com
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I had to mix it with 95% peg400 and 5% DMSO. But I think that's about it.
I found some evidence that extrapituitary prolactin is mediated by testosterone (maybe by dht?) in mice prostate.
Indeed it is an inference from the fact that in castrated mice there is no trace of ePRL in prostate tissue, while with the administration of exogenous testosterone we find ePRL.
If ePRL in follicles were mediated by androgens in humans, we would have found the connecting link of why antiandrogens work for Androgenetic Alopecia.
It must be said that there is also evidence that the expression of ePRL in the follicles appears to be increased by estrogen, but only with regard to the regulation of follicular cycles.
If this intuition were correct, obviously there would be no other way than silencing PRLR with antibody, or antagonizing it (I am referring to those who still believe that the chaste tree or other dopaminergics can help)
Indeed it is an inference from the fact that in castrated mice there is no trace of ePRL in prostate tissue, while with the administration of exogenous testosterone we find ePRL.
If ePRL in follicles were mediated by androgens in humans, we would have found the connecting link of why antiandrogens work for Androgenetic Alopecia.
It must be said that there is also evidence that the expression of ePRL in the follicles appears to be increased by estrogen, but only with regard to the regulation of follicular cycles.
If this intuition were correct, obviously there would be no other way than silencing PRLR with antibody, or antagonizing it (I am referring to those who still believe that the chaste tree or other dopaminergics can help)
"Increasing evidence demonstrates the presence of ePRL, as well as its receptors, in male reproductive organs. ePRL mRNA was detected in the dorsal and lateral prostate of rats using Northern blotting and in situ hybridization. Immunostaining localized the protein to secretory granules of the apical cytoplasm of epithelial cells. Expression within the prostate was activated by testosterone, with castrated rats producing no ePRL whereas treatment with exogenous testosterone restored its production. This was confirmed in vitro using cultured prostatic cells, which express ePRL only in the presence of testosterone..."
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Interesting study, thanks for sharing. Just browsing it and here's some more interesting bits.
My theory has been that DHT increases binding of prolactin to its receptor by increasing oxygen, which increases intracellular pH. There is a 500-fold change in the dissociation rate of PRL to its receptor between pH 8.3 and pH 5.8. DHT>Oxygen/ROS>alkaline PH>increased PRLR binding>IL-6/STAT3/5/Twist1>Wnt shutdown>loss of progenitor cells>hair miniaturization>shiny dome. There's much more to it than this of course, but hair loss is caused by interruption of the Wnt pathway and this is triggered by the AR and PRLR. This study you found further supports this.
Dermal papilla cells under hypoxia do not react the same way to DHT. https://pubmed.ncbi.nlm.nih.gov/25647436/
Frontiers | Amelioration of Androgenetic Alopecia by Algal Oligosaccharides Prepared by Deep-Sea Bacterium Biodegradation
Androgenetic alopecia (Androgenetic Alopecia) is a dihydrotestosterone (DHT)-mediated hair loss disorder characterized by shortened anagen hair cycle. Oligosaccharides derived...
www.frontiersin.org
It seems more clear all the time that blocking the PRLR is more important than the AR.
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Isn't that too short a period for it to have made any difference?
Nyet
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@pegasus2 in a joking mood, that's pretty unusual. Good to know your spoofs are of great quality, just as the rest of your posts
As a buffoon myself, I can only invite you to pull more of these. Thanks for the good laugh
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We're doing a second round of the group buy for larger quantities. DM me if interested and you missed out the first time
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Have there been any dose-ranging studies with oral SMI-1? If known. how long is the half-life? I'm not interested in using it topically, just orally.
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Did anyone in australia participate in the first round of the group buy? I'm cautious about the stuff potentially getting confiscated by customs.
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Just one I believe, and some kiwis too
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I know Pegasus said topical SMI was 'cope'. Is there anyone still pursuing the topical route with this or share any experience of it. Am considering jumping into this next or a subsequent group buy and just wanted to know if topical is a no-go. Thanks.
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We haven't done enough dose ranging yet, we know at least two of our members have been consistent with topical right from the start and have been experiencing good results so far. We've pulled the trigger on the GB but you can still get in on it in the next few days if you want to.