Prolactin "minitherapy" with SMI-1 (novel protocol for lowering prolactin locally)

[Tom4362]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

It wasn't for Androgenetic Alopecia, but for women that have Endometriosis

 

[Throwaway94]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

There's no such thing as a phase 1 specifically for Androgenetic Alopecia. There's phase 1 for the drug itself which is something of a dose / safety / tolerability trial rather than a measure of response.

 

[trialAcc]

I didn't know the Phase 1 was conducted already for Androgenetic Alopecia*.. Can you link the study?

Phase 1 just measures safety, they don't look at results. For Kintor's topical AA/degrader they applied it on people's backs for phase 1.

Only issue I have with this phase 1 is that without males in the study, there could be surprises in the phase 2 when it's conducted on males. Otherwise the HMI drug seems pretty safe imo.

 

[Micky_007]

Phase 1 just measures safety, they don't look at results. For Kintor's topical AA/degrader they applied it on people's backs for phase 1.

Only issue I have with this phase 1 is that without males in the study, there could be surprises in the phase 2 when it's conducted on males. Otherwise the HMI drug seems pretty safe imo.

Exactly the reason I'm also concerned about the safety for males since they weren't in the safety study.

 

[trialAcc]

Exactly the reason I'm also concerned about the safety for males since they weren't in the safety study.

I wouldn't be too concerned, there will be more then enough safety data from phase 2.

 

[RolfLeeBuckler]

I wouldn't be too concerned, there will be more then enough safety data from phase 2.

Can you pleite gute us the link about the Fact that only women participated in the Trial?

How is it passable that they can start a Phase 2 trial in men without even doing Phase 1 for them?
Which dangerous Effects could only happen in men but not in women in Phase 2?

 

[kuba197]

Can you pleite gute us the link about the Fact that only women participated in the Trial?

How is it passable that they can start a Phase 2 trial in men without even doing Phase 1 for them?
Which dangerous Effects could only happen in men but not in women in Phase 2?

Just take into account that for researchers, sexual side effects are not dangerous.

 

[RolfLeeBuckler]

Just take into account that for researchers, sexual side effects are not dangerous.

So the worst thing you Can get is erectyle dysfunction and loss of libido?

But getting cancer wouldnt be possible?

 

[scientist_0005]

people here do not understand how phase 1 clinical trials work and what they are looking out for

 

[roxie0k]

hi everyone, I`m the new one

 

[RolfLeeBuckler]

people here do not understand how phase 1 clinical trials work and what they are looking out for

Yes we don’t Unterstand. Thats why we are in this Forum and ask questions

 

[RolfLeeBuckler]

How could they possibly know that from a 3 month trial?

I always thought that Phase 1 is For safety. If they only control the patients After 3 months For safety concerns this trial Makes no sense in my opinion...

Phase 2 should be a dosing and a efficacy trials without serious risks For the patients

 

[justinbieberscombover]

 

[RolfLeeBuckler]

Phase I is just for dose ranging and making sure people won't drop dead immediately

Replicel/Shiseido Phase 1 Trial was 5 year follow Up data. Thats what i Call „safety Trial“

 

[RolfLeeBuckler]

HMI will have follow-up data too. Unlike Replicel they won't wait for 5 years of follow-up data before starting their next trials lol

They Did Phase 1 Trial in 2019 do there should be 3 Years data. But Where it is?!

 

[RolfLeeBuckler]

That doesn't typically get released, anyways it's only 2 years and they were only in the drug for 90 days so it wouldn't prove safety anyway. Even Phase III doesn't prove safety. Drugs have looked safe in all trials then come on the market and killed people

If you had the Choice to participate in Phase 2 trials of HMI-115 would you do that?

What is your opinion of These Treatment regarding dangerous events? I think it is just prolactin receptor, no stem cells no Castor oil. This should be safe i think...

 

[trialAcc]

They Did Phase 1 Trial in 2019 do there should be 3 Years data. But Where it is?!

Dude, no one supplies this information. They dose patients for 3 months and ask for patient feedback, test blood for liver/kidney damage, and see if they drop dead. Then they report that data.

Welcome to the global clinical trial process.

 

[RolfLeeBuckler]

Dude, no one supplies this information. They dose patients for 3 months and ask for patient feedback, test blood for liver/kidney damage, and see if they drop dead. Then they report that data.

Welcome to the global clinical trial process.

So Replicel was lot more professional then bayer regarding the data review of 5 Years phase 1 Trial

 

[RolfLeeBuckler]

Replicel has to keep reporting new stuff to get more money from suckers. Forget you ever heard the name replicel

Hope Medicine raised 65 Million Dollar!!!‘ and i don’t know Where they put the money in. They didnt Start Trial they don’t have a website...

 

[baldlygoing]

They bought a really nice yacht. The rest went to hookers and drugs

So basically $65 mill is the cure lol.