Puretech Health - 2017 Annual Report (2018-04-16)

[d3nt3dsh0v3l]

Sorry but that is "bald" not balding. He's bald.

The point wasn't the aesthetics of that hole in his hair. The point was this isn't even his final form!

brb reaching my final NW7+ form by 32, probably (guess based on family members).

 

[Noisette]

Hey Noisette, thanks again

Do you have any idea if this treatment could work on FUE/FUT scars or in somehow scarred areas?

hey @MrV88

According to their patents, it will work on the FUE/FUT scars

It's A good question If you can give a look on their patent you can see that Follica use their device on the scar of an Hair transplant " hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method "

source: http://www.google.ch/patents/WO2012065065A1?cl=en

7.14 TREATMENT FOLLOWING FOLLICULAR UNIT

TRANSPLANTATION

[00741] A 51 year old white male with history Androgenic Alopecia undergoes Hair Transplant with the "Strip Harvesting Method" with donor area located at the posterior scalp along the occipital protuberance. Surgery requires a long scar on the posterior scalp measuring 28 cm. Starting Day 1 , topical Compound is applied only to the 14 cm "left" portion of the scar (in addition to routine wound care), one time per week. In 3 and 6 week follow-up, the right and left aspects of the scar are compared with respect to skin thickness, return of pigmentation, re-establishment of adnexal structures and global assessment the physician and patient's satisfaction regarding the cosmetic result of the 2 distinct lesions using a Visual Analogue Scale (VAS).

[00742] In a variation, hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method.

 

[MrV88]

hey @MrV88

According to their patents, it will work on the FUE/FUT scars

It's A good question If you can give a look on their patent you can see that Follica use their device on the scar of an Hair transplant " hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method "

source: http://www.google.ch/patents/WO2012065065A1?cl=en

7.14 TREATMENT FOLLOWING FOLLICULAR UNIT

TRANSPLANTATION

[00741] A 51 year old white male with history Androgenic Alopecia undergoes Hair Transplant with the "Strip Harvesting Method" with donor area located at the posterior scalp along the occipital protuberance. Surgery requires a long scar on the posterior scalp measuring 28 cm. Starting Day 1 , topical Compound is applied only to the 14 cm "left" portion of the scar (in addition to routine wound care), one time per week. In 3 and 6 week follow-up, the right and left aspects of the scar are compared with respect to skin thickness, return of pigmentation, re-establishment of adnexal structures and global assessment the physician and patient's satisfaction regarding the cosmetic result of the 2 distinct lesions using a Visual Analogue Scale (VAS).

[00742] In a variation, hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method.

Thank you! Time to get a transplant, follica will save us xD

Even if one or two transplants would be sufficient for a good coverage of already bald areas this could lead to a regenerated skin with new hair on it. No more FUE/FUT scars.

 

[THALL]

hey @MrV88

According to their patents, it will work on the FUE/FUT scars

It's A good question If you can give a look on their patent you can see that Follica use their device on the scar of an Hair transplant " hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method "

source: http://www.google.ch/patents/WO2012065065A1?cl=en

7.14 TREATMENT FOLLOWING FOLLICULAR UNIT

TRANSPLANTATION

[00741] A 51 year old white male with history Androgenic Alopecia undergoes Hair Transplant with the "Strip Harvesting Method" with donor area located at the posterior scalp along the occipital protuberance. Surgery requires a long scar on the posterior scalp measuring 28 cm. Starting Day 1 , topical Compound is applied only to the 14 cm "left" portion of the scar (in addition to routine wound care), one time per week. In 3 and 6 week follow-up, the right and left aspects of the scar are compared with respect to skin thickness, return of pigmentation, re-establishment of adnexal structures and global assessment the physician and patient's satisfaction regarding the cosmetic result of the 2 distinct lesions using a Visual Analogue Scale (VAS).

[00742] In a variation, hair that is regenerated in the treated donor area may -be used as a source of future, repeated hair transplants in accordance with the foregoing method.

Well, never thought about this, sounds good! But then, they would need to achieve a somewhat significant increase in hair percentage, something like 100 hairs per cm2...and then you could transplant the newly created, supposedly dht resistant hairs on the scalp. I wonder if Follica's method works best on the donor area than the balding areas

 

[MrV88]

Well, never thought about this, sounds good! But then, they would need to achieve a somewhat significant increase in hair percentage, something like 100 hairs per cm2...and then you could transplant the newly created, supposedly dht resistant hairs on the scalp. I wonder if Follica's method works best on the donor area than the balding areas

Good quequest, but I would be happy if it could just "repair" the donor area and 25-50 hairs/cm² because the donor area ain't fully empty like the bald ones

 

[PeggyPeterson]

Hey,

Newbie here. Can someone tell me what follica is exactly working on. I hear they have a device that wounds the scalp, and topical treatment that encourages follicle neo genesis. What’s in the compound? Is it known? Would neo-genesis mean we use it just once?

Any journals? Clinical trials? Proof of concept?

I’m in no way doubting this emerging treatment, just want to learn a bit more and the official page for follica lacks substance.

 

[dermrafok]

Hey,

Newbie here. Can someone tell me what follica is exactly working on. I hear they have a device that wounds the scalp, and topical treatment that encourages follicle neo genesis. What’s in the compound? Is it known? Would neo-genesis mean we use it just once?

Any journals? Clinical trials? Proof of concept?

I’m in no way doubting this emerging treatment, just want to learn a bit more and the official page for follica lacks substance.

Europe Clinical Trial Register:
A Study to Explore the Effect of Controlled Cutaneous Perturbation and Pharmacologic Modulation for Inducing Follicular Neogenesis
Link:
https://www.clinicaltrialsregister.eu/ctr-search/search?query=follica

Start Date: 2010-07-21. It's old but now you can imagine that they are quite advanced.
On the other hand they are a private company. They are not required to disclose information to anyone.

 

[PeggyPeterson]

How do I get access to the full thing? Doesn’t show any results. I’m guessing it’s not available for public eyes?

I’m guessing the commentary from follica is positive, hence why people are optimistic ?

 

[RoyMunsonned]

What happens next? How long will support work these hair? Minoxidil for many does not work in 3-5 years.?

At that point you use whichever other treatments have come along (Tsuji ideally)

 

[H]

Dude that's pretty good for his age. Almost 60 with an intact hair line and like a NW3v? I'd easily trade with him. He's not bald. He's balding still, at his age. If he pulls off Follica, then he can probably fill that spot within a year.

At ~ 25 hairs per cm I don't believe that's filling in with Follica.

 

[Jake lake]

http://puretechhealth.com/our-pipeline/wound-induced-neogenesis-rain

don't know if repost but they have updated their 'expected milestones and timing' text:

• Our RAIN pivotal study is expected to commence following the completion of an ongoing optimization study.

 

[Kagaho]

At ~ 25 hairs per cm I don't believe that's filling in with Follica.

You have been following Follica threads for long but still you cant even grasp the basics

This is what follica expects for the average users:

 

[THALL]

You have been following Follica threads for long but still you cant even grasp the basics

This is what follica expects for the average users:

3-4x times? How many hairs is that?

 

[Kagaho]

3-4x times? How many hairs is that?

Difficult to say precisely but the the average minoxidil responder: increase of 20 - 25 hairs per cm2.

I think a good responder (based on anecdotal, clinical evidence and Follica's estimations) can expect 70 - 100 hairs maybe?

 

[H]

Difficult to say precisely but the the average minoxidil responder: increase of 20 - 25 hairs per cm2.

Please site your source.

 

[Kagaho]

Please site your source.

posted it on this very same thread. Cant do everything for you

 

[H]

posted it on this very same thread. Cant do everything for you

No where on this thread have you sited any sources claiming that the average minoxidil user regrows ~20 to 25 hair per cm? Not anywhere ive seen which is good because it's false. Some people on current methods get some regrowth but that is the exception rather than the rule most people get a stabilization of hair loss from current therapies.

I think a good responder (based on anecdotal, clinical evidence and Follica's estimations) can expect 70 - 100 hairs maybe?

You've also not provided the source for this clinical evidence at all you posted an old picture from follica with blue hairs saying it'll regrow ~3 4x hairs the current interventions which is not a lot and certainly not 70 - 100 hairs given the evidence thus far.

 

[Kagaho]

No where on this thread have you sited any sources claiming that the average minoxidil user regrows ~20 to 25 hair per cm? Not anywhere ive seen which is good because it's false. Some people on current methods get some regrowth but that is the exception rather than the rule most people get a stabilization of hair loss from current therapies.


You've also not provided the source for this clinical evidence at all you posted an old picture from follica with blue hairs saying it'll regrow ~3 4x hairs the current interventions which is not a lot and certainly not 70 - 100 hairs given the evidence thus far.

My bad, it was on a similar thread
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746236/
https://www.ncbi.nlm.nih.gov/pubmed/29028377

Remember that the first iteration of Follica will not differ much from minoxidil + Some form of Skin Disruption

 

[Kagaho]

Also, here you have some pics showing why you shoudnt discourage people

 

[H]

Also, here you have some pics showing why you shoudnt discourage people

If people want those results I would encourage them to use the same methods the study used and not even have to wait for Follica.