RU 250mg per day is actually working

Doingitright

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Update: using a single dose of 0.5mg ORM-15341 made my gyno flare up. It subsided now so I'm going to start on a super low dose of 0.01mg because this stuff is POTENT af.
You need to be careful sounds like your bodies hormones are in chaos, I really do not agree with the stacking of multiple drugs to counter act the sides of another drug, where does this end? if its making you happy then crack on but this is not sustainable in the long term and you do not want to cause permanent damage.
 

AndrewBarnes

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You need to be careful sounds like your bodies hormones are in chaos, I really do not agree with the stacking of multiple drugs to counter act the sides of another drug, where does this end? if its making you happy then crack on but this is not sustainable in the long term and you do not want to cause permanent damage.
Thanks for looking out and I agree with you that what I'm doing right now isn't recommended from a health stand point. What I'm trying to accomplish right now is determine the lowest dose of ORM-15341 I can tolerate without getting gyno sides. After I find that dose, my plan is to get off the Ralox and hopefully the AI but I think a low dose of AI is required for ORM to not get sides, no matter the dose. The reason I'm sticking with ORM is because it's the most potent anti-androgen I tried, it's FDA approved, and it's by far the cheapest antiandrogen for hair. At 0.5mg a day (which is a really potent dose), it would cost me 17.5 cents a day / $64 per year. I speculate that the highest dose I could tolerate per day would be 0.1mg a day, which would cost me $13 per year (not including the money spent on AI and the ethanol/PG vehicle).
 

Pls_NW-1

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For how long?
A few weeks.

I will give it another 6 months, and I will extend my regimen.

People with severe hair loss at young age shouldn't stick with only 5ARi's, they're literally powerless (I faced many cases).
 

AndrewBarnes

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Update: I over did it with the AI recently because the past couple of days I felt lethargic, no libido at all, very emotional, depressed, and honestly a little suicidal (I never feel suicidal). I woke up today feeling the same way but I decided to take 2-3 pumps of Dermacrine to increase my estrogen and I swear within literally 10 minutes of me applying the Dermacrine to my legs, I felt my lethargy evaporate, my libido came rushing back, and I gained more energy than even the coffee this morning gave me. Dermacrine is incredible. I can't recommend it enough and it could literally be a life saver. Please be careful with AI everyone. They're no joke.
 

Isneezedsohard

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Update: I over did it with the AI recently because the past couple of days I felt lethargic, no libido at all, very emotional, depressed, and honestly a little suicidal (I never feel suicidal). I woke up today feeling the same way but I decided to take 2-3 pumps of Dermacrine to increase my estrogen and I swear within literally 10 minutes of me applying the Dermacrine to my legs, I felt my lethargy evaporate, my libido came rushing back, and I gained more energy than even the coffee this morning gave me. Dermacrine is incredible. I can't recommend it enough and it could literally be a life saver. Please be careful with AI everyone. They're no joke.
Be careful, my dude. Hormones r no joke. That's why im so hesitant to use my biestro.
 

AndrewBarnes

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Be careful, my dude. Hormones r no joke. That's why im so hesitant to use my biestro.
Couldn't agree more. Hormones are powerful and will give you benefits but there is always a cost. Just to add to my previous post, I also experienced my first ever anxiety attack from low estrogen. I also had no appetite at all. I would barely eat anything but after taking the Dermacrine, I actually feel hungry.
 

BetaBoy

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Thanks for looking out and I agree with you that what I'm doing right now isn't recommended from a health stand point. What I'm trying to accomplish right now is determine the lowest dose of ORM-15341 I can tolerate without getting gyno sides. After I find that dose, my plan is to get off the Ralox and hopefully the AI but I think a low dose of AI is required for ORM to not get sides, no matter the dose. The reason I'm sticking with ORM is because it's the most potent anti-androgen I tried, it's FDA approved, and it's by far the cheapest antiandrogen for hair. At 0.5mg a day (which is a really potent dose), it would cost me 17.5 cents a day / $64 per year. I speculate that the highest dose I could tolerate per day would be 0.1mg a day, which would cost me $13 per year (not including the money spent on AI and the ethanol/PG vehicle).
Maybe focus more on sorting out the vehicle because it sounds like your current solution is as effective as IV administration.
 

GRme11

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Be careful, my dude. Hormones r no joke. That's why im so hesitant to use my biestro.
I am wondering if Bi-Estro could be helpful for my low E2 levels (But maybe I am wrong since there is a difference in the tissues than serum, but from the systemic absorption I guess it could raise it. Still pretty risky though). My latest blood test came only 4.5 pg/ml.

@AndrewBarnes Sorry for that and if I am screwing your thread, I just wanted to mentioned it since we talked about hormones. Thank you.
 

Doingitright

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Update: I over did it with the AI recently because the past couple of days I felt lethargic, no libido at all, very emotional, depressed, and honestly a little suicidal (I never feel suicidal). I woke up today feeling the same way but I decided to take 2-3 pumps of Dermacrine to increase my estrogen and I swear within literally 10 minutes of me applying the Dermacrine to my legs, I felt my lethargy evaporate, my libido came rushing back, and I gained more energy than even the coffee this morning gave me. Dermacrine is incredible. I can't recommend it enough and it could literally be a life saver. Please be careful with AI everyone. They're no joke.
What kicked off my hair loss journey was a steroid cycle in my early 20s which lead to me using letrozole for mild gyno, reversed the problem almost instantly but I had a shed which took years to recover from. I am very apprehensive about toying with aromatase inhibitors now for this reason, I honestly do not believe there is a healthy medium.

However if you find something that works for you then good stuff!
 

BetaBoy

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What kicked off my hair loss journey was a steroid cycle in my early 20s which lead to me using letrozole for mild gyno, reversed the problem almost instantly but I had a shed which took years to recover from. I am very apprehensive about toying with aromatase inhibitors now for this reason, I honestly do not believe there is a healthy medium.

However if you find something that works for you then good stuff!
Should have used Raloxifene, better efficacy against gyno and pretty hair safe but it's more likely aas's caused the shed and loss theres no hair safe way of doing cycles.
 

Doingitright

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Should have used Raloxifene, better efficacy against gyno and pretty hair safe but it's more likely aas's caused the shed and loss theres no hair safe way of doing cycles.
Yup true, I learned the hard way!
 

AndrewBarnes

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Maybe focus more on sorting out the vehicle because it sounds like your current solution is as effective as IV administration.
I'm not sure why I'm getting sides from such a small dose (0.5 mg) but maybe other people who have used ORM or Daro in the past with no sides didn't have legit substances? Also, what vehicle would you recommend? DMSO, Liposomal, PG, KB, ethanol, etc.?
 

BetaBoy

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I'm not sure why I'm getting sides from such a small dose (0.5 mg) but maybe other people who have used ORM or Daro in the past with no sides didn't have legit substances? Also, what vehicle would you recommend? DMSO, Liposomal, PG, KB, ethanol, etc.?
I'm not well versed on transdermal delivery vehicles but clearly you need to significantly reduce the percent of penetration enhancers so, yeah no DMSO lol. So putting my broscience cap on, I'd iteratively reduce the concentration of ethanol, and add purified/distilled water and assess if the solution is still producing systemic sides.
 

AndrewBarnes

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I'm not well versed on transdermal delivery vehicles but clearly you need to significantly reduce the percent of penetration enhancers so, yeah no DMSO lol. So putting my broscience cap on, I'd reduce the concentration of ethanol, and add purified/distilled water and assess if the solution is still producing systemic sides.
The vehicle I'm using right now is 52.5% ethanol / 17.5% water / 30% PG. I'm using everclear 75%, thus 17.5% water. Do you know the purpose of PG in a vehicle? The only reason I use it is because that's what everyone recommends.
 

BetaBoy

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The vehicle I'm using right now is 52.5% ethanol / 17.5% water / 30% PG. I'm using everclear 75%, thus 17.5% water. Do you know the purpose of PG in a vehicle? The only reason I use it is because that's what everyone recommends.
Didn't realise you were using water, just noticed you mentioning ethanol and PG earlier. No doubt more knowledgable people can chime in.
 

AndrewBarnes

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Update: I'm noticing that my gyno slightly flared up from 0.01mg of ORM-15341, even though I'm on 60mg Ralox. I'm cutting the dose down even further to an absurd 0.0025mg. This stuff will either literally last me my entire lifetime (0.0025mg per day = 1 gram per year) or it's not going to be effective due to it going systemic.
 

Pls_NW-1

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Update: I'm noticing that my gyno slightly flared up from 0.01mg of ORM-15341, even though I'm on 60mg Ralox. I'm cutting the dose down even further to an absurd 0.0025mg. This stuff will either literally last me my entire lifetime (0.0025mg per day = 1 gram per year) or it's not going to be effective due to it going systemic.
Do you experience any anti-androgenic sides?
No more oily skin, no oily scalp, dry hair!?
 

AndrewBarnes

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Do you experience any anti-androgenic sides?
No more oily skin, no oily scalp, dry hair!?
I definitely don't have an itch but aside from that I experience no other effects from the ORM besides the gyno flare ups. I want to find the dose that I can take daily or every other day to finally see the results it has for hair over a period of a month. This stuff is no joke. 250mg of RU per day makes my gyno flare up but it only takes 0.01mg of this stuff (the half life is 10x longer tho).

My gyno isn't even that bad compared to actual prostate cancer patients who take anti androgens. All I have is a puffy right nipple. I have seen pictures where a guy literally grew out double D breasts on flutamide. I didn't know that was possible until I saw those photos.
 

Pls_NW-1

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I definitely don't have an itch but aside from that I experience no other effects from the ORM besides the gyno flare ups. I want to find the dose that I can take daily or every other day to finally see the results it has for hair over a period of a month. This stuff is no joke. 250mg of RU per day makes my gyno flare up but it only takes 0.01mg of this stuff (the half life is 10x longer tho).

My gyno isn't even that bad compared to actual prostate cancer patients who take anti androgens. All I have is a puffy right nipple. I have seen pictures where a guy literally grew out double D breasts on flutamide. I didn't know that was possible until I saw those photos.
Crazy, I can't believe that you literally can develop female breasts only by AA. I wonder if gyno surgery will put that off permanently....
 
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