Been on seti for 2 months now as part of pg protocol.
There is no consensus as of yet speaking long term use.
Topical vs oral: at current prices, topical is waaaay more efficient. Oral could be better at ~1mg/day, could be not, who knows? Right now, topical is the way to go.
One thing is clear, seti stops shedding. Almost right away.
In my case(diffuse thinner), almost all of my miniaturized hairs fell out and new thick hairs are growing in their place plus more. Clear signs or regrowth. Not bad for 2 months use.
Areas of my temples that were bald for awhile reacted a little different. First i saw some really thin almost invisible hairs cover the whole area. I could pull them out easily. Now those hairs are getting darker and becoming thicker, but still not anywhere near my real hair.
There are compounds in developments that are even better pgd2 inhibitors compared to seti(ADC3680).