Stemson is going to use minipigs in the next stage of their hair cloning research

Pls_NW-1

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it seems that the treatment should be renewed every 10-15 years. The CEO strives for a cost-effective solution. He brought into play that further treatments could be free of charge.
Is this because they aren't androgen-isnensitive follicles? I mean, if you still get decent/amazing results, I can't complain.
 

werefckd

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yes but they must have had to spend a lot still on r&d for that and other things they patent. Their cell process is patented as well. Unlike tsuji they chose to differentiate into Neural crest cells and they said that played a significant role in hair induction using their method. From their publication "Our results suggest that the intermediate step of hESC differentiation into the NC lineage seems is critical, skipping the NC induction results in a complete loss of hair-inducing activity"
Yes. Notice that this quote is from one of the earliest studies, when they were still using human embryonic stem cells (hESC). They have switched to human iPSC for a while now, they work the same for what they want to do, have less regulatory problems and stigma, and are more practical.
 

werefckd

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Can you link me, because I read one of the press releases regarding fortunis investment and they mentioned R&D.. not clinical trials iirc.

Hairclones treatment isn't the same as stemsons at all, other than the fact they are using multiplication techniques. Hairclone is purely injections.

Stemson will be using a transplantation process, either with bio-degradable scaffolds or current techniques (surgeon insertion). This wont be covered by UK specials. I'm from the UK, I'd love stemson be able to utilise this route. But it's purely for 'medicines' currently.

"Funding from impact investor Fortunis will support research and development of the product solution and position the UK as a leading contender to conduct human clinical trials, including the construction of a clinical manufacturing facility."
 

werefckd

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Wait,
I just found this thread.

Is Stemson Therapeutics really, legit?
Like, a permanent solution!?
Can't find on their website if the new follicles are modified to be insensitive to androgens...

Would love to get more infos, as it sounds to be real, and I really think these kind of multiplication procedures can be a real thing in near future (2030-2060).
They are legit. Their approach, if it ends up working, will be able to potentially restore a slick bald NW7 into a NW0 with full density. We still don't now if the "cloned" hairs will be hormone sensible or not, but since they are bio engineering the new hairs from scratch I would bet anything is possible.

And Stemson is the only shot we have for a de facto cure so pray for them.
 
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werefckd

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I wonder if success in minipigs would be enough to attract big investors who can financially support their human trials. I personally don't feel like mice and minipig would make that much of a difference.
The minipig represents a huge step from the mice model. Minipigs have scalps that work more closely to humans, and it's where they will develop and test and perfect many different protocols and hopefully pick the right one that is going to be used in humans in the clinical trials. It's called pre clinical trials for a reason - totally different than experimenting on mice.

On mice it was just a proof of concept, the hair looked "natural" but not really. The minipigs will be the actually ones getting a real looking human hair (hopefully), with the protocol that will be later used on human beings.
 
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Pls_NW-1

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They are legit. Their approach, if it ends up working, will be able to potentially restore a slick bald NW7 into a NW0 with full density. We still don't now if the "cloned" hairs will be hormone sensible or not, but since they are bio engineering the new hairs from scratch I would bet anything is possible.

And Stemson is the only shot we have for a de facto cure so pray for them.
Seems like those hair will be like the ones you had when you were a baby, in theory. So they probably arent that "old" to be thaaat androgen sensitive. Every 10-15 years sounds plausible. What if you just do stemson and then maintain with finasteride and other stuff. That sounds pretty good.

I feel like the next decades will give us some new stuff. :) finally, there is something more to restore your hair besides HRT lol
 

JaneyElizabeth

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Yes. Nowadays people live up to their 100's years. And when you are 60 you just hit half of your life lol so whats wrong with having hair with the other half haha :)
And HRT has given me a decade back in terms of concomitant health improvements. We are all going to be refining our bodies and minds going forward more or less like Huxley predicted in Brave New World. I find it a thrilling time to be alive.
 

Pls_NW-1

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And HRT has given me a decade back in terms of concomitant health improvements. We are all going to be refining our bodies and minds going forward more or less like Huxley predicted in Brave New World. I find it a thrilling time to be alive.
Well... thats the power of estrogens = rejuvination. No joke.

Myb I will consider bite the bullet as well, as I get older haha
 

Pls_NW-1

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The studies with minipigs is the last step before we see people getting cloned hair. It won't take long for is to find out if Stemson is succeeding or not.

In 2 years from now tops we will be able to know.
I hope that this new stemson treatment will give you such a natural look, that people, who don't know you, wouldn't think you suffered of Androgenetic Alopecia. That would really be like a dream would come true, and I would pay for this dream a lot to become true :)
 

Pls_NW-1

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There is a fact that hairs have a finite cycles, Do these new hair have that information?
If you create completely new follicles, the new follicles should actually be like the ones made when you were in your mothers womb lol. Isn't that correct?! I wonder if this treatment will allow people have hair again, due to age, or even give old ladies and men hair back with juvenile texture, density and pigmentation.
That would be sick, ngl
 

Pls_NW-1

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trialAcc

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Rip, so that means they will align to the old follicles' cycle? And not work as completely new bioengenired follicles?

If so... then... that wont help much with Androgenetic Alopecia xD
What? No, because these follicles would be alive...and probably DHT resistant if I had to guess. The only characteristic they would probably share with your native hair is the color. The density and texture would be new.
 

eeyore

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The minipig represents a huge step from the mice model. Minipigs have scalps that work more closely to humans, and it's where they will develop and test and perfect many different protocols and hopefully pick the right one that is going to be used in humans in the clinical trials. It's called pre clinical trials for a reason - totally different than experimenting on mice.

On mice it was just a proof of concept, the hair looked "natural" but not really. The minipigs will be the actually ones getting a real looking human hair (hopefully), with the protocol that will be later used on human beings.
Ah, guess I was being too pessimistic, it makes sense when you put it like that. If they plan to do many trials and perfect the technique then $15M and 3-5 years of preclinical seems reasonable.

Can you also elaborate on why you think using IPS cells could lead to less regulatory roadblocks as opposed to ES cells?
 

jan_miezda

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What? No, because these follicles would be alive...and probably DHT resistant if I had to guess. The only characteristic they would probably share with your native hair is the color. The density and texture would be new.
Stemson didnt say they will be androgen resistant. Why will they be if they carry the same transcriptome i don't think it will be. But they said their technology can have allogenic applications one day.
 

jan_miezda

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Dosent matter your hair took like 15-20 years to die since its was created . Meaning new one even if its not dht restitent would take Alot of time. The things you worry about are pointless we need to see that stemson will not stuck at the same place tsuji was failed. Thats whats scare me the most ...
yes I’m not really worried about that like other people because you will have unlimited grafts Within 1-2 year we will know if this technology works

It has barely been 1 decade since the Nobel prize winner who derive human iPSC.

I don’t think tsuji failed. But they are set back many years now because of their partner suspending business
 
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