Stemson is going to use minipigs in the next stage of their hair cloning research

Super Metroid

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Their latest hires have been: Sabrina Maisel, PhD & Kelly Rubin. These are some other notable people they've hired recently: Stemson Therapeutics Announces Additions To Its Scientific Advisory Board | Business Wire
I googled them, Kelly Rubin is a relatively recent University graduate. Possibly very talented, but I don't think she already has that much experience with clinical trial processes.

About Maisel, this is her LinkedIn profile: https://www.linkedin.com/in/sabrina-maisel-89314036/

Also, possibly a great researcher and communicator, but not necessarily somebody with specific knowledge in human trials.

So far, I do not see how the recent hires are a clear sign that human trials are immenent.
 

froggy7

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that's why I signed up for cryonics, it will be the worst thing to die and otherwise hope, and you see how the dawn changes for the better, do you imagine dying when you discover how to make a man beautiful perfect strong with unlimited amount of healthy hair?
 

Super Metroid

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that's why I signed up for cryonics, it will be the worst thing to die and otherwise hope, and you see how the dawn changes for the better, do you imagine dying when you discover how to make a man beautiful perfect strong with unlimited amount of healthy hair?
If everybody here would get 1 follicle for the times you mentioned that you "signed up for cryonics", we would already have achieved it ;)
 

Super Metroid

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If they said that then that's not a good thing because some of us can't use minoxidil or finasteride.
As far as we know, they are currently testing in pigs. Nobody simple knows if it will even work in humans and if so, if maintenance drugs will be required to keep it.
 

froggy7

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"Geoff Hamilton: That is a good question. It is on our mind, and the idea is to generate long lasting, durable hair follicles, and some of the biology behind DHT resistance is not yet known. And so, as we are performing our experiments and biological discoveries, we’re actually collecting donated hair follicles from patients getting hair transplant procedures and those follicles which are extracted from the back of the head are known to be DHT resistant when they are moved to the recipient location of the head, and they have shown to be long lasting and durable. So, we are using those donated hair follicles for several reasons: 1) it helps us establish a benchmark when establishing our hair cells. We ask, ‘what do they look like compared to normal adult hair follicle cells?’ and 2) it gives us a source of material that helps us look deeper into ‘what is DHT resistance?’ and ‘how does that compare to hairs that are not DHT resistant?’ And the strategy for exactly how we’re going to do that is not crystal clear just yet, it is in the plan; we are frankly just a bit more focused at the moment on consistently, reproducibly building a hair follicle. At the second phase we will focus on DHT resistance and the aesthetic value of the hair – subjects like thickness of hair, color and curl. That is the kind of stuff that I would call the second phase of development. "
 

werefckd

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“Because the hair germs are neonatal-like,” Hamilton explains, “they are less susceptible to the biochemicals—dihydrotestosterone (DHT), for instance—that damage the dermal papilla in the hair follicle.” As the new hair follicle is formed, its clean, natural environment should offer some protection from those biochemicals.

Whether, or how long, that protection lasts in humans must be determined in clinical trials. To further improve the chances that hair will grow and that the hair follicles will remain healthy, Stemson plans to assess naturally resistant follicles to identify their key protective properties. The company may use those findings to guide hair germ selection.
 

RagnarLothbrok

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If they can clone DHT-resistant donor area follicles it will be good enough. Most people with transplants keep their donor hair for a long time even if they lose all native hair. And even if you lost them, then you can do it again and again anyway.
 

Bf20

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"Geoff Hamilton: That is a good question. It is on our mind, and the idea is to generate long lasting, durable hair follicles, and some of the biology behind DHT resistance is not yet known. And so, as we are performing our experiments and biological discoveries, we’re actually collecting donated hair follicles from patients getting hair transplant procedures and those follicles which are extracted from the back of the head are known to be DHT resistant when they are moved to the recipient location of the head, and they have shown to be long lasting and durable. So, we are using those donated hair follicles for several reasons: 1) it helps us establish a benchmark when establishing our hair cells. We ask, ‘what do they look like compared to normal adult hair follicle cells?’ and 2) it gives us a source of material that helps us look deeper into ‘what is DHT resistance?’ and ‘how does that compare to hairs that are not DHT resistant?’ And the strategy for exactly how we’re going to do that is not crystal clear just yet, it is in the plan; we are frankly just a bit more focused at the moment on consistently, reproducibly building a hair follicle. At the second phase we will focus on DHT resistance and the aesthetic value of the hair – subjects like thickness of hair, color and curl. That is the kind of stuff that I would call the second phase of development. "
Geoff made that statement in September 21'. So we can safely assume that stemson were at that stage 1 1/2 - 2 years.
 

ratty

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So, development will continue several years before a treatment enters human trials, and a few years will pass before that treatment becomes available, assuming it succeeds.

will check back in after 10 years then
 

Super Metroid

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it would be nice if this will take only 10 years:)
Some years for preclinical trials, a couple of years for the actual trials and a couple of years for creating the infrastructure that this treatment would require. Will indeed take a long time even assuming that everything succeeds.
 

froggy7

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Some years for preclinical trials, a couple of years for the actual trials and a couple of years for creating the infrastructure that this treatment would require. Will indeed take a long time even assuming that everything succeeds.
it is not for us only for next generations, 10 years is a very good timeframe:)
 

Raccooner

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Back to the pigs. If we look to the end of the article, Geoff I think gives us a clue. They've must have had some degree of success with some pigs, but the consistency needs work. The key is if they got any human hair to grow in a pig then there is much more proof that hair cloning concept has the ability to work for our skin type as well. Hopefully the new hires will figure out a way to deal with the consistency issue.

Also, Stemson placed a new position for an Assistant Lab Technician. No doubt they're active but wonder how they can afford their payroll hiring so many people? Additionally, the article mentions needing funding for the clinical trial, whenever that comes. Wondering what that would run? Perhaps what they really need is a fundraiser or sales specialist who can recruit a benefactor?
 

RagnarLothbrok

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The problem with Stemson is not only a scientific research one but a manufacturing one. Even if they could find a 100% reliable system to clone a hair follicle, that doesn't mean that they can do it at scale for profit. It's a very complex situation sadly.
 

froggy7

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The problem with Stemson is not only a scientific research one but a manufacturing one. Even if they could find a 100% reliable system to clone a hair follicle, that doesn't mean that they can do it at scale for profit. It's a very complex situation sadly.
100% true, there will ba also a problem with price
 

Super Metroid

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Back to the pigs. If we look to the end of the article, Geoff I think gives us a clue. They've must have had some degree of success with some pigs, but the consistency needs work. The key is if they got any human hair to grow in a pig then there is much more proof that hair cloning concept has the ability to work for our skin type as well. Hopefully the new hires will figure out a way to deal with the consistency issue.

Also, Stemson placed a new position for an Assistant Lab Technician. No doubt they're active but wonder how they can afford their payroll hiring so many people? Additionally, the article mentions needing funding for the clinical trial, whenever that comes. Wondering what that would run? Perhaps what they really need is a fundraiser or sales specialist who can recruit a benefactor?

I think it is kind of a stretch to interpret that sentence as a clue that they are already experiencing some degree of success. They might, but to conclude it is reading too much into it I believe.

Investors are generally smart people, you don't earn your way to collecting the kind of money to invest by falling for cheap marketing tricks. Hiring a sales specialist is imo only a good idea if there are significant results to show: glad to see Stemson is focusing on that.

Absolute best case scenario is that they are close to finishing the preclinicals and find a sponsor that is willing to take the financial burden but demands they trial in Asia for speed reasons. If that works out and they commercialize there, they can slowly build-up the infrastructure and industry while actually treating patients on a small scale and earn money while working towards trialing in the West.

But scenario's usually don't pan out so well, plus it would still be very costly :)
 
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