OverMachoGrande
Senior Member
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Bryan said:Lord_Justin13 wrote:
Bryan wrote:
Lord_Justin13 wrote:
Bryan wrote:
You're claiming that 5a-reductase binds to SHBG? Really?
Please note:
http://www.androgeneticalopecia.com/hai ... ness.shtml
...Additionally, in humans Ketoconazole has also been shown to inhibit the binding of 5 -reductase to sex hormone globulins.[...]
Quote:
I'll have to let you off the hook for that, since you were only quoting the link above. However, what they say is ridiculous. SHBG doesn't bind to 5a-reductase! What they probably MEANT to say is that ketoconazole inhibits the binding of SHBG to sex hormones, which is obviously quite another matter. They got their facts all screwed-up!
Is that your opinion?
How is what they say ridiculous?
Please provide evidence to support your claim.
I don't think SHBG even enters cells, so there's no way it can bind with 5a-reductase. If you know otherwise, cite the evidence from a medical journal article or study.
I cited the website above, if that's not enough for you, too bad.
from their site;
Androgenetic alopecia . com provides the most important information you need to know about androgen induced hair loss, but much more information is available on other sites. Sometimes our viewpoint differs from other web sites and it is worth reviewing several sites to get a rounded view of hair loss and the treatments available.
They said, a new school of thought, you know, maybe that means they are breaking the barrier on older, more linear ways of medical research.
You know, the earth was flat once too....
Bryan said:Lord_Justin13 wrote:
Bryan wrote:
Lord_Justin13 wrote:
Quote:
After being processed by the liver, Finasteride makes it's way to the 'water' system, where it moves into the prostate and prevents an important natural enzyme from being created, through the unnatural down regulation of the 5-alpha reductase.
AGAIN: give us a medical reference or citation for that.
10th grade, Human Biology, But hey, maybe I'm wrong, I mean it could be eaten by the liver, then moved to the lungs where you exhale the drug.
What the hell is THAT supposed to mean? Do you have a medical reference, or not?
It means what I said, it's in regards to how the human body naturally functions, I can't help how food/water is processed.
"It means what I said"?? Is that the best you can do?
Okay, again, let's try to finish the sentance,
It means what I said, it's in regards to how the human body naturally functions, I can't help how food/water is processed.
Come on Bryan, there's this thing called evolution. These days we speak in complete sentences.
Bryan said:Lord_Justin13 wrote:
Bryan wrote:
Lord_Justin13 wrote:
Quote:
Lord_Justin13 wrote:
This is what Finasteride mainly assists with, Through halting the 5-alpha enzyme from being created, thus, there is no catalyst for tesosterone to become DHT.
Again, please give us a medical reference or citation that supports that claim.
http://www.ftmguide.org/hairloss.html#finasteride
There is nothing at that link which supports your claim.
let's take another look shall we?
from the website cited above....,
The drug Finasteride was initially prescribed to men in the United States under the drug name "Proscar" to treat enlarged prostate glands. A side effect of the medication was that it caused hair growth in a significant number of the patients. It is now marketed in the U.S. as "Propecia" to treat mild to moderate hair loss in men.
Ok, ready to read the words with me?
Finasteride is a type II 5-alpha reductase inhibitor. Type II 5-alpha reductase (type II 5aR) is an enzyme that is responsible for converting testosterone into DHT (described in detail above). Finasteride blocks the action of type II 5aR, thereby inhibiting DHT production in the hair follicles. A daily dose of 1mg can effectively lower DHT levels by as much as 60%.
Let me repeat that,
Finasteride is a type II 5-alpha reductase inhibitor.
Finasteride blocks the action of type II 5aR.
Finasteride keeps 5a-reductase from producing DHT by BINDING to it (also known as INHIBITING it). In that way it "blocks" the action of type II 5a-reductase. But it doesn't stop the enzyme from being created. I'm shocked that you don't know that! Anybody who spends any time at all on hairloss sites knows that, probably even most complete newbies.
I do know it, your just upset on how it's presented.
I'll re-quote myself, again, I made a grammatical error, in fact, I'll go back and change it, to something that better suites your English.
The fact is, no matter how I type it, it doesn't change the fact that your penis shrivels after 3 months, PERMANENTLY!
I quote the following website;
http://www.propeciasideeffects.com/
Propecia Side Effects
Propeciasideeffects.com was formed to spread the word about the undocumented potentially irreversible side effects caused by using Propecia (finasteride) 1mg each day. A number of males have suffered erectile dysfunction, impotence, low libido and gynecomestica after using Propecia. The shattering truth for these males is that the side effects did not disappear after ceasing finasteride. The shattering truth is that years later these individuals are still suffering in silence with a seriously reduced quality of life due to erectile dysfunction and impotence. It is not know exactly what causes these changes and how to screen individuals before treatment.
The purpose of this site is to spread the word to others considering using Propecia and also to provide as an informational exchange and gathering place for those who are already suffering.
--They created their own website for men with ruined lives.
LONG TERM SIDE EFFECTS OFFICIAL
January 2009 (Links fixed)
A special investigation of Propecia led by the Swedish Medical Products Agency has resulted in changes to the Prescription Information for Propecia:
Investigation of Propecia by Swedish MPA (Link is in Swedish for English information see link at the end of this article.)
Among the most important changes are (in section 4, "Possible Side Effects"):
"* Persistent difficulty having an erection after discontinuation of treatment.
* Infertility has been reported in men who took finasteride for long time and had other risk factors that may affect fertility. Normalisation or improvement of seminal quality has been reported after discontinuation of finasteride. Long-term clinical studies about the effect of finasteride on fertility in men have not been conducted."
http://www.propeciahelp.com/forum/viewtopic.php?t=2002
Possible CLASS ACTION LAW SUIT (Canada)
October 2008
If you live in Canada and are suffering from unresolved Finasteride side effects despite quitting Propecia or Proscar, CLICK HERE TO REGISTER for a possible class action lawsuit.
Your contact information will be forwarded to a lawyer who may be in touch should the case proceed in the future. http://www.propeciaclassaction.com
more from wikipedia;
Side effects
Side effects of finasteride include impotence (1.1% to 18.5%), abnormal ejaculation (7.2%), decreased ejaculatory volume (0.9% to 2.8%), abnormal sexual function (2.5%), gynecomastia (2.2%), erectile dysfunction (1.3%), ejaculation disorder (1.2%) and testicular pain. Resolution occurred in men who discontinued therapy with finasteride due to these side effects and in most of those who continued therapy.[10]
In December 2008, the Swedish Medical Products agency concluded a safety investigation of Propecia and subsequently advised that the use of Propecia may result in irreversible sexual dysfunction. The Agency's updated safety information lists difficulty in obtaining an erection that persists indefinitely, even after the discontinuation of Propecia, as a possible side effect of the drug.[11] The United Kingdom's Medicines and Healthcare products Regulatory Agency also now warn against persistent erectile dysfunction after use of Propecia.[citation needed]
Finasteride is not indicated for use by women. Finasteride is in the FDA pregnancy category X. This means that it is known to cause birth defects in an unborn baby. Women who are or who may become pregnant must not handle crushed or broken finasteride tablets, because the medication could be absorbed through the skin. Finasteride is known to cause birth defects in a developing male baby. Exposure to whole tablets should be avoided whenever possible, however exposure to whole tablets is not expected to be harmful as long as the tablets are not swallowed. It is not known whether finasteride passes into breast milk, and thus should not be taken by breastfeeding women. Finasteride may pass into the semen of men, but Merck states that a pregnant woman's contact with the semen of a man taking finasteride is not an issue for concern.[12] Finasteride is known to affect blood donations, and potential donors are typically restricted for at least a month after their most recent dose.[13]
Finasteride has been linked with depression.[14] The drug also caused reductions in allopregnanolone, a potent, endogenous positive modulator of the GABAA receptor, in very large doses in rodent studies.[15]
Many sports organizations have banned finasteride because it can be used to mask steroid abuse.[16] Since 2005, finasteride has been on the World Anti-Doping Agency's list of banned substances. However, it was removed from the list in 2009.[17] Notable athletes who used finasteride for hair loss and were banned from international competition include skeleton racer Zach Lund, bobsledder Sebastien Gattuso, footballer Romário and ice hockey goaltender José Théodore.[18]
Possible health concerns
The UC Berkeley Wellness Letter expressed concern in March 2003 about the unproven long-term safety of Propecia and recommended cutting a standard 1-milligram dose of Propecia into quarters to reduce the cost without reducing its effectiveness. This claim appears to be supported by clinical pharmacological data reviewed by the FDA during Propecia's approval process that suggested that the advantage of taking 1 mg per day over 0.2 mg per day is statistically small.[19] Some people have unsuccessfully petitioned the FDA to re-examine the approved dosage in light of the statistical evidence and unknown long-term risks.[20] The FDA responded and said that just because the level of DHT found in the scalp was not significantly different does not mean there is a correlation with hair loss. A study would have to show that the benefits of using 0.2 mg and 1 mg were not statistically different. According to the FDA, such a study has been performed, and a 1 mg dose has a greater benefit whilst remaining equally safe. The same study also concluded that doses of 0.01 mg per day were found to be ineffective in treating hair loss.[20]
In December 2009, the Medicines and Healthcare products Regulatory Agency in the UK announced new drug safety advice on finasteride and the potential risk of male breast cancer. The agency concluded that, although overall incidence of male breast cancer in clinical trials for finasteride 5mg was not significantly increased, a higher risk of male breast cancer with finasteride use cannot be excluded. A warning on this risk will be included in the product information.[21]
:nono:
So...
Canada class action lawsuit, finasteride is banned.
UK, possible ban, warns citizens of high risk side effects.
impotence (1.1% to 18.5%), abnormal ejaculation (7.2%), decreased ejaculatory volume (0.9% to 2.8%), abnormal sexual function (2.5%), gynecomastia (2.2%), erectile dysfunction (1.3%), ejaculation disorder (1.2%) and testicular pain
And how many men have never reported side effects?
How many didn't realize these side effects happened to them while on propecia?
No 'side effect' should be anywhere NEAR 18.5, REPORTED.
Bryan said:Lord_Justin13 wrote:
Quote:
Below are a couple of posts (made on two different occasions) by Jonathon Fromme, over on HLH a few years ago. He is a doctor (pathologist), and wrote these things in support of what I'd been saying over there about the popular Urban Myth that finasteride was supposedly an "accidental discovery":
"Bryan is right--finasteride was CLEARLY designed to treat male pattern baldness. I wrote about this 5 years ago on this site, but I'm not sure the record is available.
I'm sorry, without any medical record, this 'doctor' and you, have no valid proof on the discovery of Finasteride. Consequently, the information I have found shows that Finasteride, was originally treated for enlarged prostate, and upon their use, discovered it's hair growth side effects.
LOL!! You're just going to ignore the evidence that Dr. Fromme presented?
I'm sorry, without any medical record, this 'doctor' and you, have no valid proof on the discovery of Finasteride. Not that I care much anyways.
Bryan said:Lord_Justin13 wrote:
Bryan wrote:
"Sebum secretion and sebaceous lipids." - published in Dermatologic Clinics, Vol. 1, No. 3, July 1983.
This was nearly 30 years ago.
Are you claiming that scientific medical research has reached it's peak, and no new discoveries can be made?!
For a more complete discussion of all the medical evidence against the "feedback theory", read the following threads over on acne.org that I created:
more you created, or your company?
Bryan said:Lord_Justin13 wrote:
Listen shills, first, this forum wasn't created for a debate on the discovery of Finasteride, or whether you can't understand what the post means.
Let me help you understand something, after sifting through your companies 5,000 websites, reading on how propecia so wonderful, I continued writing, and made a grammatical error, that's it, a grammatical error. After seeing (INHIBIT), (RENDERS USELESS) etc.. I just worte down what they said, what YOUR companies said.
I've demonstrated to you that YOU made a completely FALSE claim about finasteride, one that you cannot prove. Let this be a lesson to you to be very very careful what you post on sites like this.
No Bryan, I didn't produce any false claim, please reference back to the original post.
A lesson to me? lol, the only lesson to be learned is to you, The fact is, 'expression' is used in place of 'action' "the enzymes expression".
In 'modern' english, this term is easily understood, as I'm sure post readers have understood it just fine.
Bryan said:Lord_Justin13 wrote:
Sir, I am compelled to ask exactly what it is you do? nearly 6,000 posts, continuous nay-saying of modern research, this bothers me, I suppose only the research you find is valid then?
Oh, and I believe I saw your same name (spelled exactly the same), at another hair loss website.
I post on several hairloss Web sites. That acne site, too.
Oh...You must have a lot of free time to be out defending propecia. Out of curiosity, has your treatment actually worked?
Lord_Justin13 wrote:
Oh yea, and there's an ongoing suspicion that you may be creating several screen names, and flooding this good informative website with more propoganda, and posing to be others, though, I hope that's not true!
LOL!! Is that REALLY what you think, or are you just embarrassed by the errors I brought to your attention, and the new information you got about the development of finasteride, and the properties of sebum?
No, I don't have other screen names. "Bryan Shelton" is my real name, and the only one I've ever used while posting on the Internet.
I could care less about how you view my writing, especially when others could grasp it in one read.
the information I show, is not about the development of finasteride. It's about diseases correlation to male pattern baldness, and how these drugs 'play' along the same route as the manifested disease.
Bryan, I don't care about the sebum. Unless your upset, cause no evidence can be shown for it?
i didn't ask for your "Name", (if that is your realname, who knows, and if it is, and you were indeed shilling, I doubt the company would put you on their "official" records.