timi,you were right all along

[Pondle]

At this time the sinergy between fina and duta (low dose) seems to show best results...

That seems like a totally pointless treatment strategy to me Andrea. The two drugs are not synergistic. They are in the same class!

 

[Bryan]

At this time the sinergy between fina and duta (low dose) seems to show best results...

I'm baffled as to why some people think there would be "synergy" between finasteride and dutasteride.

 

[Bryan]

Somebody also wrote that the half-life is partly dependent on the dosage? I don't know enough about pharmacology to make sense of that.

Just keep in mind that at the dose of 0.1 mg/day of dutasteride, the half-life drops to a little over three days (on average, of course), according to the Gisleskog et al studies on dutasteride and finasteride.

Nice graph, Pondle! Shows everything at a glance!

 

[Andrea]

Brian can you explain the shedding without end and hairs straw which some people shows with Dutasteride?
Finasteride has a good affinity with Alpha Reductase type 2 but didn't work against type 1 which is expressed in sebaceous glands and instigates the inflammation on the scalp...
Dutasteride inibits both types but some patients didn't tolerate 0,5mg daily.
So you can buy solid Duta and cut it or take Dutasteride 0,5mg weekly (type 1) and Fina other days to mantain low DHT levels.
Brian do you think that 2 caps of Duta at week are enought without fina?
When I was on 0,5mg daily disaster!!!!!!!!!!!
When I was 2caps weekly good
When I started Fina daily an Duta 1 week get better!!!!

 

[Renegade]

As I have discussed before, the only explanation that I can come up with at this time to explain such a phenomenon is that a finasteride/dutasteride "combo" creates some "optimal" ratio of Type I/II inhibition.

This would actually be a bad thing in general b/c it would suggest that the DHT/male pattern baldness relationship was even more complex than previously thought. Also, not many have been willing to deviate from standard dosing (there is absolutely no evidence to back this theory up) and those that are willing would basically have to experiment for themselves to find their "optimal" combo.

With that said, I am seeing more and more regimens that experiment w/ some sort of combo or less-than-standard dutasteride dosage. They may just be doing this for price or safety, I don't know.

 

[hair today gone tomorrow]

Well,
the inibitors of 5 Alpha Reductase are dose-dipendent, more drug more results, there is no doubt...
But Dutasteride is a drug with a long life in the blood and if you don't tolerate 0,5mg die you can take 1 or 2 caps/week and obtain result better than finasteride everyday.
The inibition of DHT in the blood is not important in male pattern baldness, but is VERY IMPORTANT tht the drug works in the FOLLICLE!

I'm not sure if taking one or two caps a week is really sufficient. When you have low doses of dutasteride, the performance is pretty similar to finasteride. I added the low doses of dutasteride to my chart of the phase II Avodart hair loss trial. Somebody also wrote that the half-life is partly dependent on the dosage? I don't know enough about pharmacology to make sense of that.

i wonder where those numbers would be after 2 years? my guess is that they would all be very close to each other.

 

[Pondle]

i wonder where those numbers would be after 2 years? my guess is that they would all be very close to each other.

The $64m question. Does dutasteride generate a persistently higher hair count than finasteride, and keep you above baseline for longer? Marty Sawaya thought that the dutasteride data would keep improving through years 1 and 2...

 

[phish]

pondle cool graph thnx, do you happen to have a graph or numbers of year count of propecia proscar and maybe dutasteride.5mg?

 

[Timi]

Andrea

When I was on 0,5mg daily disaster!!!!!!!!!!!
When I was 2caps weekly good
When I started Fina daily an Duta 1 week get better!!!!

i have the same Experience

Harms dutasteride with a Full Dose??
Low Dose not harms but then also not better than finasteride??

I think dutasteride is not for everybody
Genetic structure of the Body is important

and for mutsch People is the best finasteride and not dutasteride

in ouer Page take mutsch Men dutasteride Dayli the Hair was bad and thin-straw
he take than dutasteride all 10-15 Days the other Days Proscar

and the Hair better!

I do not believe that dutasteride is better than finasteride for the most Men
(Single successes OK this says Prof. Hoffman)

And this Graphic I do not believe in it

Timi

 

[Pondle]

pondle cool graph thnx, do you happen to have a graph or numbers of year count of propecia proscar and maybe dutasteride.5mg?

I have a comparison of Propecia and Proscar (notice how they get to the 'same place', so to speak, by 12 months) but dutasteride has never been studied for hair loss over a year in a large trial - there was that small study of identical twins, I'm discounting that.

 

[phish]

thats kind of weird that propecia would have higher hair count then proscar in a year.

 

[CCS]

thats kind of weird that propecia would have higher hair count then proscar in a year.

I don't think it has more. Just a few hairs more becaue of statistical noise. It seems that dutasteride and proscar work faster than propecia, but are no stronger at the 1 year mark. Now dutasteride 2.5mg per day gets higher above baseline than propecia ever does, so that is interesting. I'd rather inhibit scalp 5ar1 with curcumin.

 

[CCS]

so avodart 0.5mg and 2.5mg regrew more in 6 months than finasteride did in 1 year at peak. I wonder if my spironolactone/EGCG/curcumin will have enough anti-androgenic activity topically to give me at least those results while only taking propecia.

 

[stax]

So in the long run does 1mg of Finesteride have the same hair growth as 0.5mg Avodart?

 

[RaginDemon]

CCS, did you try dutasteride before?

 

[CCS]

CCS, did you try dutasteride before?

I took dutas EOD for 6 months. I'm not sure if I lost hair or if it just looked that way after my hair grafts, or if I had some shock loss. But it scared me enough that I got back on finasteride.

 

[Timi]

dutasteride all Days 0,1mg
is this a way?
(Kombie with Proscar)

when i take 0,5mg all 3-4Days i have Big Side Effekt

with a little Dose 0,1mg No side Effects

Timi

 

[Andrea]

0,1 dutasteride everyday is OK but no Komb with Proscar..
Solid Duta by Genhair is valid or it may be fake?
Thanks

 

[Timi]

Andrea

why not Proscar to dutasteride??

in ouer Page make this all with good sucess

under dutasteride allone Hair Straw

one Men takes Dayli 0,5mg dutasteride and 2x1,25mg finasteride
he has a Great success
this Dose for me to heavy

dutasteride one Day and the other Day 1,25mg proscar
and so on? (all 2Days 0,1Dut)

Here from Hairlosshelp a good dutasteride success
http://www.hairlosshelp.com/forums/mess ... SGDBTABLE=

Timi

 

[CCS]

I plan to take finasteride 1.25 mg every other day, and dutasteride 0.1mg every other day. That should cover more types of 5ar, hopefully. Then my topical EGCG and curcumin should help too.