Update: Insuline Resistance and Hairloss
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purecontrol
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Bryan said:
And this is why Brian is both fat and bald, too much ego and not enough room for hair or a brain.
Brian fails to understand context of converstaion yet once again. :thumbdown2:
squeegee
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Cancer Res. 2011 Jul 14. [Epub ahead of print]
Insulin increases de novo steroidogenesis in prostate cancer cells.
Lubik AA, Gunter JH, Hendy SC, Locke JA, Adomat HH, Thompson V, Herington A, Gleave ME, Pollak M, Nelson CC.
Source
Australian Prostate Cancer Research Centre Queensland, Queensland University of Technology.
Abstract
Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissue. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer, however, regression initially seen with ADT gives way to development of incurable castration-resistant prostate cancer (CRPC). While ADT generates a therapeutic response, it is also associated with a pattern of metabolic alterations consistent with metabolic syndrome including elevated circulating insulin. Since CRPC cells are capable of synthesizing androgens de novo, we hypothesized that insulin may also influence steroidogenesis in CRPC. In this study, we examined this hypothesis by evaluating the effect of insulin on steroid synthesis in prostate cancer cell lines. Treatment with 10 nM insulin increased mRNA and protein expression of steroidogenesis enzymes and upregulated the insulin receptor substrate IRS2. Similarly, insulin treatment upregulated intracellular testosterone levels and secreted androgens, with the concentrations of steroids observed similar to the levels reported in prostate cancer patients. With similar potency to DHT, insulin treatment resulted in increased mRNA expression of the prostate specific antigen PSA. CRPC progression also correlated with increased expression of IRS2 and insulin receptor in vivo. Taken together, our findings support the hypothesis that the elevated insulin levels associated with therapeutic castration may exacerbate progression of prostate cancer to incurable CRPC in part by enhancing steroidogenesis.
Insulin increases de novo steroidogenesis in prostate cancer cells.
Lubik AA, Gunter JH, Hendy SC, Locke JA, Adomat HH, Thompson V, Herington A, Gleave ME, Pollak M, Nelson CC.
Source
Australian Prostate Cancer Research Centre Queensland, Queensland University of Technology.
Abstract
Androgen-dependent pathways regulate maintenance and growth of normal and malignant prostate tissue. Androgen deprivation therapy (ADT) exploits this dependence and is used to treat metastatic prostate cancer, however, regression initially seen with ADT gives way to development of incurable castration-resistant prostate cancer (CRPC). While ADT generates a therapeutic response, it is also associated with a pattern of metabolic alterations consistent with metabolic syndrome including elevated circulating insulin. Since CRPC cells are capable of synthesizing androgens de novo, we hypothesized that insulin may also influence steroidogenesis in CRPC. In this study, we examined this hypothesis by evaluating the effect of insulin on steroid synthesis in prostate cancer cell lines. Treatment with 10 nM insulin increased mRNA and protein expression of steroidogenesis enzymes and upregulated the insulin receptor substrate IRS2. Similarly, insulin treatment upregulated intracellular testosterone levels and secreted androgens, with the concentrations of steroids observed similar to the levels reported in prostate cancer patients. With similar potency to DHT, insulin treatment resulted in increased mRNA expression of the prostate specific antigen PSA. CRPC progression also correlated with increased expression of IRS2 and insulin receptor in vivo. Taken together, our findings support the hypothesis that the elevated insulin levels associated with therapeutic castration may exacerbate progression of prostate cancer to incurable CRPC in part by enhancing steroidogenesis.
squeegee
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Androgen excess is a common feature of PCOS, which is also the most common cause of anovulatory infertility. The ovarian theca cells increase their ovarian androgen production under the stimulatory activity of the raised LH levels, and in many cases, raised insulin levels.
Hyperinsulinemia due to peripheral insulin resistance is often present in women with PCOS and it promotes hyperandrogenemia through the binding of insulin to the insulin-like growth factor–1 (IGF-1) receptor. Insulin mimics the action of insulin growth factor 1 (IGF-1), which augments androgen production by the theca cell in response to LH. Since insulin decreases levels of SHBG, the circulating levels of free testosterone are also increased.
Hyperinsulinemia due to peripheral insulin resistance is often present in women with PCOS and it promotes hyperandrogenemia through the binding of insulin to the insulin-like growth factor–1 (IGF-1) receptor. Insulin mimics the action of insulin growth factor 1 (IGF-1), which augments androgen production by the theca cell in response to LH. Since insulin decreases levels of SHBG, the circulating levels of free testosterone are also increased.
Ok, first of all I love you guys. Secondly, all this talk about insulin resistance, eating habits, sleeping habits etc.. I have noticed have a per individual impact on hair. I have two buddies, yes I can link you to pictures, that have the most god awful diets. My friend eats fast food everyday, Carl's Jr., Taco Bell, you friggin' name it. He use to be an amateur Tennis pro and is still a coach today and remains very active. He also sleeps about 5 or 6 hours a night. I've known the guy for quite some time now and his hair, to say the least, is *ucking perfect!
Take friend #2, Cuban. Eats like a moose, white rice, meats and a lot of them, drinks coffee like a moose and is a nurse that works in the ER for the nightshift. I go out to eat with him sometimes because, my diet is so extremely healthy that I choose not to 90% of the time. His hair, *f*****g perfect and a lot of it.
So, all this talk of insulin and IGF-1 and you name it, I feel it really is only individually important because these are two instances (and I live in Los Angeles where every other guy has a ridiculous head of hair) where these theories and or studies have no relevance whatsoever.
Just a guy who's lurked these forums for 4 years now, making observations.
Take friend #2, Cuban. Eats like a moose, white rice, meats and a lot of them, drinks coffee like a moose and is a nurse that works in the ER for the nightshift. I go out to eat with him sometimes because, my diet is so extremely healthy that I choose not to 90% of the time. His hair, *f*****g perfect and a lot of it.
So, all this talk of insulin and IGF-1 and you name it, I feel it really is only individually important because these are two instances (and I live in Los Angeles where every other guy has a ridiculous head of hair) where these theories and or studies have no relevance whatsoever.
Just a guy who's lurked these forums for 4 years now, making observations.
K
kehcorpz
Guest
I'm sure to a small degree this may impact hair loss. I implore you to go on a no carb diet and see what happens to your hair 
. Ketones are pretty toxic and only good for short term for survival purposes. Not meant to be exposed constantly.
Anyways, I know many diabetics and people with insulin resistance that have amazing hair. You will not change Male Pattern Baldness with your diet. Any stress a non-carb diet induces may increase your shedding. I know health nuts that have been healthy since their teens that are completely bald. A healthy diet is always great to keep you functioning and provide you with more energy but it wont change your genetics. Your scalp already has sebaceous glands that produce DHT and destroy the follicle. You need something that will prevent this production. I think there might be something out there called Propecia? Yah that's it. Anyways, even strong drugs like propecia may only SLOW down your balding. But this gives science more time to create better drugs, so get on it!
. Ketones are pretty toxic and only good for short term for survival purposes. Not meant to be exposed constantly.Anyways, I know many diabetics and people with insulin resistance that have amazing hair. You will not change Male Pattern Baldness with your diet. Any stress a non-carb diet induces may increase your shedding. I know health nuts that have been healthy since their teens that are completely bald. A healthy diet is always great to keep you functioning and provide you with more energy but it wont change your genetics. Your scalp already has sebaceous glands that produce DHT and destroy the follicle. You need something that will prevent this production. I think there might be something out there called Propecia? Yah that's it. Anyways, even strong drugs like propecia may only SLOW down your balding. But this gives science more time to create better drugs, so get on it!
powersam
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K
kehcorpz
Guest
powersam said:
They still eat some carbohydrates:
Inuit consume a diet of foods that are fished, hunted, and gathered locally. This may include walrus, Ringed Seal, Bearded Seal, beluga whale, caribou, polar bear, muskoxen, birds (including their eggs) and fish. While it is not possible to cultivate plants for food in the Arctic the Inuit have traditionally gathered those that are naturally available. Grasses, tubers, roots, stems, berries, fireweed and seaweed (kuanniq or edible seaweed) were collected and preserved depending on the season and the location
Their life expectancy is much lower and they do not age very well.
One could argue its the conditions but they have evolved for them. They are also known for having abnormally large livers and have many health issues. They also drink seal blood because they believe it makes them stronger, so you should too. Maybe your hair will grow.
powersam
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kehcorpz said:I'm sure to a small degree this may impact hair loss. I implore you to go on a no carb diet and see what happens to your hair
http://en.wikipedia.org/wiki/Vilhjalmur_Stefansson#Low-carbohydrate_diet_of_meat_and_fish
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ -
Long-term effects of a ketogenic diet in obese patients
K
kehcorpz
Guest
powersam said:kehcorpz said:I'm sure to a small degree this may impact hair loss. I implore you to go on a no carb diet and see what happens to your hair
http://en.wikipedia.org/wiki/Vilhjalmur_Stefansson#Low-carbohydrate_diet_of_meat_and_fish
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ -
Long-term effects of a ketogenic diet in obese patients
No doubt that dropping body weight in a non-ketogenic fashion will have the same effect. Give me a break. Quote something reliable that tests a controlled group that drops body weight with a non-ketogenic diet.
http://www.ncbi.nlm.nih.gov/pubmed/22498698
Point is moderation is best, you don't want too high blood sugar and you don't want your blood ketones too high as both are unhealthy.
That is exactly what you are doing when you are on a ketogenic diet. You are producing ketone bodies. Your liver is under serious stress too. You empty your muscles and liver of glycogen which it uses as a secondary energy sources after adenisone tri-phosphate splits to adenisone dual phosphate which is very short lived.
Ketone bodies also decarboxylate into acetone which in high amounts is toxic and even in low amounts is a central nervous system depressant. Stop jumping on the Atkins craze and realize Inuits have a shorter life span for a reason.
There are so many studies showing the ill effects of ketosis I'm not going to spend my entire day posting back and forth. There are many variables to consider. HDL and LDL and BMI are not the only things that occur in the body.
powersam
Senior Member
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kehcorpz said:powersam said:kehcorpz said:I'm sure to a small degree this may impact hair loss. I implore you to go on a no carb diet and see what happens to your hair
http://en.wikipedia.org/wiki/Vilhjalmur_Stefansson#Low-carbohydrate_diet_of_meat_and_fish
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/ -
Long-term effects of a ketogenic diet in obese patients
No doubt that dropping body weight in a non-ketogenic fashion will have the same effect. Give me a break. Quote something reliable that tests a controlled group that drops body weight with a non-ketogenic diet.
Are you being deliberately obtuse? You state that long term ketosis is not healthy, I have given you two sources which prove that wrong.
Post them.
K
kehcorpz
Guest
Yes Wiki is a source. Let me write up a wiki page with some facts and post it....powersam said:
You clearly don't understand science. Do you not get that any obese people that lose weight will show improvement in those areas? Once again there are other factors than HDL and LDL. If you do not measure for them you will not see if they are impacted. I have a background in biochemistry and have read my fair share if poor studies I don't need to read more. This is a hair loss forum. As I mentioned I will not go back and forth with links. You believe what you want and see how your hair does. I will continue taking propecia and enjoy the fruits of real science.
powersam
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http://www.jbc.org/content/87/3/651.full.pdf+html
1. Two men lived on an exclusive meat diet for 1 year and a third man for 10 days. The relative amounts of lean and fat, meat ingested were left to the instinctive choice of the individuals.
2. The protein content varied from 100 to 140 gm., the fat from 200 to 300 gm., the carbohydrate, derived entirely from the meat, from 7 to 12 gm., and the fuel value from 2000 to 3100 calories.
3. At the end of the year, the subjects were mentally alert, physically active, and showed no specific physical changes in any system of the body.
4. During the 1st week, all three men lost weight, due to a shift in the water content of the body while adjusting itself to the low carbohydrate diet. Thereafter, their weights remained practically constant.
5. In the prolonged test, the blood pressure of one man remained constant; the systolic pressure of the other decreased 20mm. and the diastolic pressure remained uniform.
6. The control of the bowels was not disturbed while the subjects were on prescribed meat diet. In one instance, when the proportion of protein calories in the diet exceeded 40 per cent, a diarrhea developed.
7. Vitamin deficiencies did not appear.
8. The total acidity of the urine during the meat diet was increased to 2 or 3 times that of the acidity on mixed diets and acetonuria [Marika: AKA ketonuria] was present throughout the periods of exclusive meat.
9. Urine examinations, determinations of the nitrogenous constituents of the blood, and kidney function tests revealed no evidence of kidney damage.
10. While on the meat diet, the men metabolized foodstuffs with FA: G ratios between 1.9 and 3.0 and excreted from 0.4 to 7.2 gm. of acetone bodies per day.
11. In these trained subjects, the clinical observations and laboratory studies gave no evidence that any ill effects had occurred from the prolonged use of the exclusive meat diet.
1. Two men lived on an exclusive meat diet for 1 year and a third man for 10 days. The relative amounts of lean and fat, meat ingested were left to the instinctive choice of the individuals.
2. The protein content varied from 100 to 140 gm., the fat from 200 to 300 gm., the carbohydrate, derived entirely from the meat, from 7 to 12 gm., and the fuel value from 2000 to 3100 calories.
3. At the end of the year, the subjects were mentally alert, physically active, and showed no specific physical changes in any system of the body.
4. During the 1st week, all three men lost weight, due to a shift in the water content of the body while adjusting itself to the low carbohydrate diet. Thereafter, their weights remained practically constant.
5. In the prolonged test, the blood pressure of one man remained constant; the systolic pressure of the other decreased 20mm. and the diastolic pressure remained uniform.
6. The control of the bowels was not disturbed while the subjects were on prescribed meat diet. In one instance, when the proportion of protein calories in the diet exceeded 40 per cent, a diarrhea developed.
7. Vitamin deficiencies did not appear.
8. The total acidity of the urine during the meat diet was increased to 2 or 3 times that of the acidity on mixed diets and acetonuria [Marika: AKA ketonuria] was present throughout the periods of exclusive meat.
9. Urine examinations, determinations of the nitrogenous constituents of the blood, and kidney function tests revealed no evidence of kidney damage.
10. While on the meat diet, the men metabolized foodstuffs with FA: G ratios between 1.9 and 3.0 and excreted from 0.4 to 7.2 gm. of acetone bodies per day.
11. In these trained subjects, the clinical observations and laboratory studies gave no evidence that any ill effects had occurred from the prolonged use of the exclusive meat diet.