Update: Insuline Resistance and Hairloss

powersam

Senior Member
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Show me how Michael Eades is 'disgraced'. Proof.

Then show me how that disproves the papers he references in those two pieces that you probably didn't read. Here is one of the papers referred to in the article - http://www.sciencedirect.com/science/ar ... 0399905204

Then go and read about ketosis and ketoacidosis. Educate yourself so you'll understand that the two are very different. You seem to be under the impression that as ketoacidosis is damaging, then ketosis must be similarly damaging to a lesser degree.

Nor is it even relevant really as one does not need to be in ketosis constantly on the Paleo diet or to minimise insulin.

But no, what you'll actually do is raise straw man arguments, ie/ talking about propecia's effectiveness, which I've never questioned., or Dr Oz?!?! , or that I claimed insulin resistance causes male pattern baldness (also never said).

Mate you've got a minor in biochem. I've got a degree in human biology. If this is an education battle, I win. You have a smattering of knowledge, and think it gives you carte blanche to discredit whatever, hence you are a prime example of when a little bit of knowledge is worse than none..

What is most interesting is that you have classified the two studies I posted as epi studies, when they are quite clearly interventional. But they probably don't teach that in computer science.


Interesting to see if you can actually stick to 'this is my last post in this thread'.

Oh and here is a bunch of studies on the benefits and safety of the Paleo diet:

Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Jr., Sebastian A: Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr 2009.

Jönsson T, Granfeldt Y, Ahrén B, Branell UC, Pålsson G, Hansson A, Söderström M, Lindeberg S. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Cardiovasc Diabetol. 2009;8:35

Jonsson T, Granfeldt Y, Erlanson-Albertsson C, Ahren B, Lindeberg S. A Paleolithic diet is more satiating per calorie than a Mediterranean-like diet in individuals with ischemic heart disease. Nutr Metab (Lond). 2010 Nov 30;7(1):85

Jonsson T, Ahren B, Pacini G, Sundler F, Wierup N, Steen S, Sjoberg T, Ugander M, Frostegard J, Goransson Lindeberg S: A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab (Lond) 2006, 3:39.

Lindeberg S, Jonsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjostrom K, Ahren B: A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Diabetologia 2007, 50(9):1795-1807.

O’Dea K: Marked improvement in carbohydrate and lipid metabolism in diabetic Australian aborigines after temporary reversion to traditional lifestyle. Diabetes 1984, 33(6):596-603.

Osterdahl M, Kocturk T, Koochek A, Wandell PE: Effects of a short-term intervention with a paleolithic diet in healthy volunteers. Eur J Clin Nutr 2008, 62(5):682-685.
 

KANGA

Established Member
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Nice, I've never really heard about the Paleolithic diet before, but this seems really interesting to try for overall health. Thanks.

Mind you, diet is a contributing factor, not cause. Obviously you understand this, but it would be a good thing if others did as well.
 

Aston

New Member
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I'm glad to see this thread. I have made a similar one on a different forum. Starting from different premises i have reached the same conclusion. Leptin Reset and Paleo Diet are the first step. Cortisol-line and thyroid supplementation the next for difficult cases or men in advanced age. The metabolic theory of hair loss also provides the best evolutionary explanation of baldness: a signal of male metabolic health to women. Men with Male Pattern Genes haven't been curbed by evolution despite the disinterest they stimulate in women because the healthy ones won't get it until late age. It is a powerful visual aid on a potential mate's health for females. Just like acne.
 

LawOfThelema

Experienced Member
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Plenty of studies have found no significant connection between the two.

Baldness could may well be a spandrel. If it is a signal for mate health it is easily overridden by culture and individual proclivities of women who still find bald men attractive, since lots of bald guys still get lots of action. And if its an overall marker for health evolution really ****ed up because healthy guys still bald. Not every "trait" that is expressed is either adaptive or maladaptive. It might not signal for anything.
 

andersonlynch

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Exercise regularly, Eat some nutritional foods.
 

2020

Experienced Member
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50
I'm glad to see this thread. I have made a similar one on a different forum. Starting from different premises i have reached the same conclusion. Leptin Reset and Paleo Diet are the first step. Cortisol-line and thyroid supplementation the next for difficult cases or men in advanced age. The metabolic theory of hair loss also provides the best evolutionary explanation of baldness: a signal of male metabolic health to women. Men with Male Pattern Genes haven't been curbed by evolution despite the disinterest they stimulate in women because the healthy ones won't get it until late age. It is a powerful visual aid on a potential mate's health for females. Just like acne.
y god

my god someone ban him already...


Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226186/?tool=pmcentrez

sorry but you are born with male pattern baldness in your genes.... eating healthier won't help.

Metabolic Syndrome was pretty much non-existent 100 years ago but people still went bald.

Sign of health??? Oh my god I see hundreds of counter-examples to that theory...
 

abcdefg

Senior Member
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782
I think castrated men never going bald, current theory of androgens, and just everyday evidence that women with high androgens lose hair while older men with no facial hair generally have 0 hair loss. My opinion is hair loss is possibly 100 percent controlled by androgens and we need to remember finasteride and dutasteride are not perfect anti androgens so those are not perfect examples of how important the role of androgens in hair loss is. Also its arguable lowering 5-ar during the balding process is the same as someone born without the 5-ar.
90 percent of men I know in real life that have peach fuzz facial hair and no body hair at old ages like 35+ have no zero hair loss. You have very up hill battle to convince me androgens are not 100 percent responsible. Now we know androgens are part of a much larger process that happens where many other things come into play such as down stream effects and immune system reactions, but androgens are 1 place we can intervene although safety is questionable.
 

Celeborn

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Yeah right, now tell me how androgen levels are totally​ unrelated to lifestyle and environment factors...
 

LawOfThelema

Experienced Member
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Two events could co-occur with 100% probability but this isn't license to say that one event (insulin resistance) caused the other event (male pattern baldness in this case).

There is often a third factor which is giving rise to or strongly contributing to both of them

Androgen receptor CAG repeat length polymorphism modifies the impact of testosterone on insulin sensitivity in men.
Möhlig M, Arafat AM, Osterhoff MA, Isken F, Weickert MO, Spranger J, Pfeiffer AF, Schöfl C.
Source


Department of Endocrinology, Diabetes and Nutrition, Charité-University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. matthias.moehlig@charite.de

Abstract

OBJECTIVE:
Low circulating testosterone concentrations have been associated with insulin resistance (IR). Androgen action is mediated by the androgen receptor (AR) whose activity is modulated by a polymorphic CAG repeat sequence within exon 1. An interaction between testosterone and CAG repeat length (CAG length) with respect to IR has been described in women.

OBJECTIVE:
We investigated such a putative interaction between testosterone and the CAG length with respect to IR in men with normal glucose tolerance.
DESIGN:

Cross-sectional study.

METHODS:
In 113 non-diabetic men calculated free testosterone, the CAG length, and a multiplicative interaction term were investigated by multiple linear regression analysis for an association with IR, as indicated by homeostasis model assessment (HOMA %S).

RESULTS:
In a multivariate regression analysis adjusted for age and body mass index, free testosterone, CAG length, and a multiplicative interaction term were significantly associated with IR (P=0.001, P=0.001, P=0.01 respectively). The model explained 36.6% of the variation of IR and predicted that in carriers with a CAG length of 23, changes in testosterone would only minimally affect IR. For CAG lengths longer than 23, however, an increase in testosterone would improve IR, namely the longer the CAG length, the greater the effect. In contrast, in the case of CAG lengths shorter than 23, the effect of increasing testosterone would be the opposite.

CONCLUSIONS:
In men, testosterone and the AR CAG repeat length polymorphism interacted with respect to IR. The interpretation of the association between testosterone and IR seems to require consideration of the AR CAG repeat polymorphism.
 

abcdefg

Senior Member
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I personally feel that androgen levels are largely in themselves genetic since most men I know with very bad early balding are generally very hairy in terms of body hair compared to others their same age. They eat/drink same stuff as me so I just really have doubts its diet I think its nearly 100 percent androgens and that diet plays very minor role if any in long term androgen levels but again I am open to scientific explanations or studies proving it wrong.
Many things in this branch of science are not intuitive or follow logic which is why science moves so slowly in areas of research trying to find cures for these kinds of problems.
 

tedlin01

Established Member
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I have diabetes Type-1 so my body produce no Insulin and I have to inject it externally. I wonder how this affects my hairloss. It started when I was 18 and I got Diabetes when I was 16 :eek:
 
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