- Reaction score
- 1,027
1) Every drug is a whole different world. Spironolactone don't go systemic cause it is metabolize . I used both, oral ( that gave me Gynecomastia, real one, and had to go for surgery to remove it ) and topical ( that didn't gave me gyno) . If you google , you will find an article wrotte by Dr Lee ( the created of Xandrox ) that explain about spironolactone not going systemic.Take a look at this and let me know what you think. I couldn't find a study on ketoconazole systemic absorption but since it's topical it should have the same rule with any topical regarding systemic absorption on the head.
2) Problem with all this studies ( there is actually one that show that ketoconazole cream don't go systemic ) are made on a single application. Only one time application, then they check the blood levels. And that is not how topicals works in real life, plus we use tons of other topics , and chronic use of lotions , specially with PG ( almost all have it ) make the skin much more permeable .
3) Even so, If studies are done, you will know if ketoconazole go systemic, cause it will shut down your testosterone production. Not all the androgens will shut it down