All we need to know about RU58841

[Bryan]

could that increase end up being permanent after discontinuing RU?

I don't see how it could be permanent.

 

[Bryan]

I would like to know this too, i think the real, honest answer would be no one knows, however if the increase in AR's was your body's natural reaction to less AR stimulation, then (and i could be totally wrong) slowly weening yourself off RU, or slowly reducing the dosage, you would allow your body time to reduce the number of AR's because of overstimulation. wheras if you just stopped dead, then all those extra AR's would suddenly be exposed to androgens?

I agree with that. That's why I've always suggested slowly tapering-off any kind of antiandrogenic therapy, instead of suddenly discontinuing it.

 

[striker9]

so RU58841 is another scam?

 

[karlg]

so RU58841 is another scam?

What makes you say that?

 

[striker9]

no pictures, no results, nothing..

 

[el_duterino]

RU is a drug that can stop further hairloss.
Take a photo today, start RU and take another photo in one year.

If you see no changes you can claim 100% success.

That's about it in terms of photographic evidence...

 

[OverMachoGrande]

RU is a drug that can stop further hairloss.
Take a photo today, start RU and take another photo in one year.

If you see no changes you can claim 100% success.

That's about it in terms of photographic evidence...

Can stop further hair loss how long? There are many drugs that can halt hair loss for a year or in some cases alot longer and also some that can even regrowth hair withing a year. For instance Minoxidil stopped my hair loss for over 2 years+ and regrew alot of hair but then the effects tapered and that is why I added Finasteride (finpecia) and then Dutasteride (Dutas) . You state " RU is a drug that can stop further hairloss " are you actually saying permanently? I am not trying to "call you out" I actually am curious and interested as to what you mean because I have no experience with RU and only know it as a very potent (and expensive) anitandrogen.

 

[el_duterino]

RU is far more effective than finasteride or dutasteride at stopping hairloss for extended period of time.

I took finasteride for 6 years, and it worked well at first but after 6 years it just could not halt male pattern baldness. Same for dutasteride.

The reason why RU is more effective:

1)RU blocks Testosterone in addition to DHT.
T can trigger hairloss without conversion to DHT, especially at the very sensitive zones such as the hairline/temples.

2)RU has very low systemic side effects, so you can use a lot more (50mg to 200mg) a day to block all the androgens.


I have been using RU for over 2 years now, I use 50mg and it works great. If it stops being sufficient I can increase dosage without having to suffer from side effects.

At 50mg a day it only costs $2 a day ($40/g)

 

[striker9]

But if it blocks so good, why doesn't it regrow a lot?

My main problem now is the temples.

 

[el_duterino]

depends by what you mean by regrow. It will thicken existing hair. some people call this regrowth

most castrated men did not regrow completly lost hair.

BUt again, some people can get lucky if the loss is very recent.

 

[dertim]

(First wrote this as a PM but thought I'd better post it in this thread)


Hey Bryan,

I read a lot of your posts on the various hair loss boards over the last couple of years. Thanks for your great contribution!

I've got one question, I would've asked in the specific thread but since you posted it on another board and I'm not registered there, I will just ask it here.

I've been very interested about RU since I first heard of it when i started coming to these boards 3 years ago. And well, I've got a bit infected with the hype el_dut started, too.


I'd really like to try it but what concerns me most is what you wrote about the purity of RU and the substances needed for the synthesis.


You mentioned phosgene, which definitely is a little scary but since it doesn't get absorbed over the skin a little contamination shouldn't be too bad ? Of course it would still be very disconcerting.

Now, my real real question: Can you tell me, which other substances are used in producing RU58841? Any additional risks?
I would only start with like 20-30mg a day, but I'm still skeptical :/
Any advice?


Thanks a lot, Tim

 

[5minabs]

el_Dut, I saw you mention the need to add PG if using more than 50mg of RU. I'm assuming this helps with better absorption? If using Everclear, could we premix it with PG, or as with RU, would we need to mix it right before application?

 

[Bryan]

I'd really like to try it but what concerns me most is what you wrote about the purity of RU and the substances needed for the synthesis.
You mentioned phosgene, which definitely is a little scary but since it doesn't get absorbed over the skin a little contamination shouldn't be too bad ? Of course it would still be very disconcerting.

I'm certainly no expert on phosgene or the extent to which it may or may not be absorbed by the skin, especially when mixed with other skin-penetrating agents like alcohol and/or propylene glycol; but like you said yourself, just the idea itself is very disconcerting! :shock:

Now, my real real question: Can you tell me, which other substances are used in producing RU58841? Any additional risks?
I would only start with like 20-30mg a day, but I'm still skeptical :/
Any advice?

I used to have a bunch of scans from medical journal studies, including one from the original Battmann paper on RU58841 which showed the steps in its chemical synthesis; however, GeoCities shut down its free posting, so I can't post that scan anymore from them. However, give me a day or two and I'll post it for you, using one of the other free sites. It shows all the chemicals used in that process, and what they do with them. After reading it, you'll have a very good idea of why the stuff is so damned expensive!

 

[BitchBoy]

How long after applying RU do you think it would be safe to apply minoxidil? At the moment I wait until the RU solution has dried completely, about 2 hours. Could I still apply the minoxidil when the RU solution is still wet or would this somehow decrease it's effectiveness?

 

[5920715]

You could use Nanominox first, wash it out after 5 mins.
Dry, then apply RU.

viewtopic.php?f=42&t=54285&st=0&sk=t&sd=a


Nanominox_MS not available any more, unfortunately.

 

[BitchBoy]

Well, I could make my RU solution dry almost instantly by using no PGG but I don't think i'd get hardly any absorption. Think that would be the same nanomox wouldn't it?

I'm more interested in what might happen if the solutions mix on the scalp.

 

[blaze]

How long after applying RU do you think it would be safe to apply minoxidil? At the moment I wait until the RU solution has dried completely, about 2 hours. Could I still apply the minoxidil when the RU solution is still wet or would this somehow decrease it's effectiveness?

Id say it would be prudent to wait at least 30 mins.

 

[thinincrown]

Is it ok to mix say 50 mg's of RU w/ 2 vials of Fluridil? I got my RU and my scale, ready to start applying......

 

[blaze]

You could do that. See if it dissolves...if it does you should be good to go. I would suggest holding the 4mls of fluridil(2 vials) mixed with 50mg of RU over a lamp and to see if the RU competely dissolved.

Make sure you massage it into the scalp too. Fluridil is basically just pure Isopropyl Alcohol whcih evaporates very fast. You dont want RU crystals being left on your scalp once the Alcohol dries which will be quite fast.

 

[thinincrown]

You could do that. See if it dissolves...if it does you should be good to go. I would suggest holding the 4mls of fluridil(2 vials) mixed with 50mg of RU over a lamp and to see if the RU competely dissolved.

Make sure you massage it into the scalp too. Fluridil is basically just pure Isopropyl Alcohol whcih evaporates very fast. You dont want RU crystals being left on your scalp once the Alcohol dries which will be quite fast.

thanks blaze, I'll give it shot...there is a little bit of grapeseed oil in the fluridil so that may help some with the drying of the isopropyl alch.

Has anyone ever added a few drops of Emu oil into their ru/alchohol mix as a substitute for Propylene Glycol?