This provides general info for chinas drug approval
www.lifepronow.com
I agree that the way the CEO is overhyping it is pretty close to scam territory.
Maybe if you wanna be infertile.
It's reversible though, and more of an issue in women.
I'm in the same boat as you. For once a company actually has actually shown efficacy in primates and not mice.
pubmed.ncbi.nlm.nih.gov
pubmed.ncbi.nlm.nih.gov
But the purpose of the PRL receptor antagonist is to prevent transcription locally in the follicle just like a local antiandrogen, just a different angle. The hair follicle produces a very small amount of prolactin just as it does DHT, systemically it's quite an insignificant amount but it's responsible for the majority of prolactin related damage to hair.Did some quick reading on the negative effects of very low prolactin as I wasn't very informed, and it apparently such a state can induce a low 5AR type state by reducing the output of adrenal androgens (DHEA for example), and can result in low DHT, which I'm guessing is where a majority of the effectiveness of this treatment comes from.
So, again, another promising treatment is going to come down to being highly anti-androgenic and whether or not you can tolerate it. I'm just going to assume that the more effective a treatment is, the more intense the side effects are likely to be. If you're comfortable with a low androgen state, I'm not sure whats keeping someone from stacking finasteride/dutasteride with ru58841, which I can't imagine wouldn't provide some results for most.
Hypoprolactinemia as related to seminal quality and serum testosterone - PubMed
Semen quality and serum testosterone were studied in six men with hypoprolactinemia (less than or equal to 6 ng/ml) and in normoprolactinemic controls. The incidence of hypoprolactinemia in 92 men attending an infertility clinic was 7.5%. Males with hypoprolactinemia showed in high percentage of...Hypoprolactinemia: a new clinical syndrome in patients with sexual dysfunction - PubMed
Our findings demonstrate that, in subjects consulting for sexual dysfunction, PRL in the lowest quartile levels are associated with MetS and arteriogenic ED, as well as with PE and anxiety symptoms. Further studies are advisable in order to confirm our preliminary results in different populations.
I truly wonder if the AR degrader would give an HRT effect in terms of hair recovery
Castration doesn't reverse hair loss so that's not how this works. A drug that targets the AR can prevent hair loss, but will never be able to give the regrowth that this does. Also, there's no point in combining finasteride with dutasteride, they do the same thing. Combing dutasteride with RU can't do more than castration, which isn't much.
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
Do we have an exact guess how many follicles get destroyed, and how long it takes? If someone is NW7 at say 25, would he still have a sufficient portion of his follicles to get back to NW1 once he'd take those drugs?Castration doesn't reverse hair loss so that's not how this works. A drug that targets the AR can prevent hair loss, but will never be able to give the regrowth that this does. Also, there's no point in combining finasteride with dutasteride, they do the same thing. Combing dutasteride with RU can't do more than castration, which isn't much.
We still have stem cells in bald scalp, they just don't proliferate anymore. Prolactin apparently is the brake that keeps HF stem cells in a quiescent state. It's my hope that if you shut down prolactin along with a Wnt agonist you'll wake up every follicle that isn't completely destroyed. That is, it's the best treatment that we could possibly have without creating new follicles.
Minireview: Prolactin Regulation of Adult Stem Cells
Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the ...
I don't know. Fibrosis can set in after a few years according to some sources. How much fibrosis is needed to destroy the follicle, maybe it takes 5 years in one person, 30 years in another. Even at 25 if you're slick bald I wouldn't get your hopes up. In the macaques, only senile monkeys failed to regrow hair. The younger they were the more hair they grew back.
Interesting question that I share. I thought follicles never died but only miniaturized heavily.
Finasteride/dutasteride was meant to imply picking either/or, not combining.
All depends on the amount of fibrosis. Keep treating your hair even if it's not working to prevent further damage so that when something like BAY does come out you can benefit from it.
jamanetwork.com