Don't Be Delusional, There Won't Be Anything Better For The Next 30 Years. Deal With It.

[Michel F. II]

ε επρεπε να την ειχα μυριστει τη μαλακια.

Δε πιστευεις στα stem cells των Ιαπωνων?

Φυσικά και πιστεύω.
Τα βλαστοκύτταρα είναι το μέλλον της Βιοϊατρικής. Μόνο ένας τρελός θα μπορούσε να ισχυριστεί τ' αντίθετο.
Το θέμα είναι ο χρόνος.
Δεν ξέρω αν η πρόοδος θα επιτευχθεί λίαν συντόμως ή μετά το 2030.
Πάντως, οι Γιαπωνέζοι σίγουρα θα παίξουν καταλυτικό ρόλο.
Κι ενόσω οι Γιαπωνέζοι θα προσπαθούν να συνθέσουν ολόκληρα όργανα, εμείς, το λίκνο της Δημοκρατίας, θα συζητάμε για το Μνημόνιο και τους δημόσιους υπαλλήλους.
Κωλόφαρδος είσαι που την έκανες.
Ελπίζω να την κάνω κι εγώ.

 

[Michel F. II]

The follicles must be in their anagen phase when someone gets the injections through replicel's aproach. How will they solve it? Often visits?
Will the multiplied cells keep their structure or they will get affected in the sick-bald area? Aderans didn't make it so it was so important working with ds than dpc's?
Stop it b****s with your abra katabrazz.

U r really turning me on with that aggressive attitude.
Haha
Do you really believe Aderans' approach is the same with Replicel's?
Btw, what does your comment have to do with mine?
I'm not talking about Replicel, I'm talking about iPSC technology, filos!

 

[InBeforeTheCure]

Sorry let me clarify. I don't see reversal happening unless it's with organ regeneration. I don't know whether they study genes in stem cells (from the ground up) for organ regen research or if they just study the molecules in those cells. And tbh why would you want to study the mechanism of a disease when your aim is to reproduce healthy stem cells and you're circumventing the whole balding process anyway.

But reversal already happens without organ regeneration. Finasteride can reverse it a little, dutasteride a little more, minoxidil a bit more, and estrogen a lot more. None of these, however, could reverse the destruction of follicles and loss of stem cells that occurs in advanced A.G.A. So it's a really a matter of how far you reverse it, and that varies depending on what treatment you use.

As for Tsuji and friends, they don't have to worry about mechanisms of the disease. All they need to know is how to culture cells from healthy follicles, expand their numbers, and place them in the bald areas in such a way that they form healthy new follicles.

 

[shookwun]

hair transplant game

Academic-hedonist seeking literature cope game


choose 1

 

[Michel F. II]

hair transplant game

Academic-hedonist seeking literature cope game


choose 1

Most hair transplants are dreadful, hun.
And not all people suffering from hair loss can have transplants.
If you don't like Game 2, just go away.
Have a hair transplant and leave us alone.
Or maybe better, scar your head extensively and have mediocre results, and get the f#ck out of this section.
Farewell

 

[lemoncloak]

But reversal already happens without organ regeneration. Finasteride can reverse it a little, dutasteride a little more, minoxidil a bit more, and estrogen a lot more. None of these, however, could reverse the destruction of follicles and loss of stem cells that occurs in advanced A.G.A. So it's a really a matter of how far you reverse it, and that varies depending on what treatment you use.

As for Tsuji and friends, they don't have to worry about mechanisms of the disease. All they need to know is how to culture cells from healthy follicles, expand their numbers, and place them in the bald areas in such a way that they form healthy new follicles.

Exactly. I think we just have different definitions of reversal

 

[lemoncloak]

hair transplant game

Academic-hedonist seeking literature cope game


choose 1

I'll pick the 2nd any day of the year like a good aspie (Not really aspie. Probably.)
Hell I'll pick the razor or a hair piece before I pay to open 5000 mini holes in my scalp just to have the hair of a 50 year old while convincing myself that mediocrity looks sharper than a clean shaved head.
But you know, everyone has different standards. If transplants make people happy who am I to judge

 

[nameless]

I don't believe replicel or shiseido will make it but that's just a feelling.I believe Tsuji is the only who can make it but if he doesn't the only thing that will solve the problem is gene editing in 20+ years.
NW3.
Oh sorry...I forgot our savior- Brotzu lotion.

I'm also pessimistic about Replicel/Shieseido regrowing a good amount of hair but I do think there's a slim chance that it might arrest hair loss.

And I also think Tsuji is our best chance for regrowth right now.

I agree that if Tsuji fails then gene editing is our next best bet. But gene editing is already starting human trials for health issues other than hair loss so I think gene editing is coming to market sooner than you think, at least for other conditions besides hair loss.

 

[nameless]

I think I'm about to become a pain in the *** for saying this again and again in this forum but all we need to do is knock out the androgen receptor gene in the follicles. It's either the trigger or a bottleneck, baldness stops 100% and no one cares about the genes downstream. Knock the whole gene out, disrupt the promoter, add more CAGs in exon1 (as in Armando's recent thread), many ways to do it. You can upregulate beta estrogen receptors too I guess, among other things, but it's probably an unnecessary risk.
The reason gene editing won't happen soon is because of regulations, delivery and possible off-targets by CRISPR. Personally I think studying Androgenetic Alopecia genes downstream of AR is redundant at this point, at least for application on Androgenetic Alopecia.

I think that trying to specifically remove the androgen receptor from ONLY the follicles in your scalp would be very difficult...if not impossible. And if they nuke all of your androgen receptors that could cause feminization of the male body and other unwanted side effects, just like anti-androgens do.

 

[MotorcycleGuy]

There will be no better treatement coming out for the next 30 years? I find that hard to believe. Hair loss is a big market with people becoming more and more obsessed with their appearance.

 

[nameless]

As for Tsuji and friends, they don't have to worry about mechanisms of the disease. All they need to know is how to culture cells from healthy follicles, expand their numbers, and place them in the bald areas in such a way that they form healthy new follicles.

But don't forget that for many of us our healthy follicles will also thin and shrink even in our donor area. As a matter of fact, it will happen to almost all of us over time. And the cells from those follicles, which are healthy today, will become less and less healthy over time so the new follicles created by the Tsuji process will also miniaturize more and more over time.

 

[InBeforeTheCure]

But don't forget that for many of us our healthy follicles will also thin and shrink even in our donor area. As a matter of fact, it will happen to almost all of us over time. And the cells from those follicles, which are healthy today, will become less and less healthy over time so the new follicles created by the Tsuji process will also miniaturize more and more over time.

I'd better keep up with this dutasteride-rich diet then, up until anti-AR gene therapy becomes available.

 

[Omega2327]

But don't forget that for many of us our healthy follicles will also thin and shrink even in our donor area. As a matter of fact, it will happen to almost all of us over time. And the cells from those follicles, which are healthy today, will become less and less healthy over time so the new follicles created by the Tsuji process will also miniaturize more and more over time.

Not to worry, this is already on their radar:

"Keiko: Thank you. Question 8: Certain individuals with advanced androgenetic alopecia experience significant miniaturization of follicles and extensive loss on the sides and back of the head. This is the typical location for donor follicles for transplants and with your therapy. As a result, these donor follicles may be extensively affected by Androgenetic Alopecia prior to the procedure. What can these people expect from your therapy?

Mr. Toyoshima: This question rather relates to the Androgenetic Alopecia clinical condition; therefore, I believe it would be more appropriate for a physician to talk about this. However, I can provide you with an answer from a biologist perspective. It is thought that the site of Androgenetic Alopecia onset is already determined in the stage wherein the follicular organ is generated, and follicular papilla cells store information such as destiny, determining the site of male pattern alopecia onset, to a certain degree. Consequently, follicles on the back of the head and those on the front of the head will have different destinies, and it is thought that patients with alopecia develop the disease in a specific site in this manner. As the disease gradually progresses, follicles on the back of the head and also those on the side of the head also become miniaturized. However, even though the disease has progressed into those areas, there is still a large number of normal follicles left. Based on this, we are currently conducting a human-tissue study using dermal tissues collected from the back of Androgenetic Alopecia patients’ heads in order to verify the possible number of normal follicles which can be collected from such areas, and whether cells collected from such areas have the function needed for follicular regeneration, etc. So far, we have found out that there is a large number of normal follicles on the back of Androgenetic Alopecia patients. We believe that collecting the cells from such areas will definitely result in regeneration of normal follicles."

 

[nameless]

Not to worry, this is already on their radar:

"Keiko: Thank you. Question 8: Certain individuals with advanced androgenetic alopecia experience significant miniaturization of follicles and extensive loss on the sides and back of the head. This is the typical location for donor follicles for transplants and with your therapy. As a result, these donor follicles may be extensively affected by Androgenetic Alopecia prior to the procedure. What can these people expect from your therapy?

Mr. Toyoshima: This question rather relates to the Androgenetic Alopecia clinical condition; therefore, I believe it would be more appropriate for a physician to talk about this. However, I can provide you with an answer from a biologist perspective. It is thought that the site of Androgenetic Alopecia onset is already determined in the stage wherein the follicular organ is generated, and follicular papilla cells store information such as destiny, determining the site of male pattern alopecia onset, to a certain degree. Consequently, follicles on the back of the head and those on the front of the head will have different destinies, and it is thought that patients with alopecia develop the disease in a specific site in this manner. As the disease gradually progresses, follicles on the back of the head and also those on the side of the head also become miniaturized. However, even though the disease has progressed into those areas, there is still a large number of normal follicles left. Based on this, we are currently conducting a human-tissue study using dermal tissues collected from the back of Androgenetic Alopecia patients’ heads in order to verify the possible number of normal follicles which can be collected from such areas, and whether cells collected from such areas have the function needed for follicular regeneration, etc. So far, we have found out that there is a large number of normal follicles on the back of Androgenetic Alopecia patients. We believe that collecting the cells from such areas will definitely result in regeneration of normal follicles."

Perhaps this might solve the problem but it does sound a little like wishful thinking. I wish they would simply cure the cell's vulnerability to Androgenetic Alopecia. Also, it might be a good idea to cryo-preserve some of these cells soon to protect them.

 

[Omega2327]

Perhaps this might solve the problem but it does sound a little like wishful thinking. I wish they would simply cure the cell's vulnerability to Androgenetic Alopecia. Also, it might be a good idea to cryo-preserve some of these cells soon to protect them.

I suppose time will tell. And that is a very interesting idea. Freeze cells to preserve their youth and then inject years down the road while they still have a relatively young life in terms of Androgenetic Alopecia. They have already started R&D for freezing and storing cells for future use, so at least we can have some reasonable basis for hope.

 

[That Guy]

There will be no better treatement coming out for the next 30 years? I find that hard to believe. Hair loss is a big market with people becoming more and more obsessed with their appearance.

You're new here; newer than even I, so let me tell you this: There are a lot of crazy people here who flat out do not want anything better to come along.

In the past two pages and in recent threads we've seen:

• At least one person who doesn't think RepliCel or Shiseido will make it, but provides no explanation other than "just a feeling"

• Another person who claims there is a slim chance that said company can arrest hairloss, despite all evidence thus far indicating it can do just that.

• People who argue that JAK inhibitors will cure hairloss, but fail to provide an explanation as to how this will regenerate the hair follicle organ and actually believe that a topical will work for Androgenetic Alopecia because "it can better reach the follicle" and somehow still believe this when shown actual scientific studies that oral JAK (much like finasteride and other drugs) has absolutely no problem reaching the follicle and toward the outermost skin.

When it comes to New Research, there are many who are downright ideologues to whom facts do not matter.

They want to wallow in self pity and believe nothing is happening and it won't matter what breakthroughs happen or how many successful trials we see — they'll still say the same things.

 

[Xander94]

FUARRRRRKKK

 

[Michel F. II]

You're new here; newer than even I, so let me tell you this: There are a lot of crazy people here who flat out do not want anything better to come along.

In the past two pages and in recent threads we've seen:

• At least one person who doesn't think RepliCel or Shiseido will make it, but provides no explanation other than "just a feeling"

• Another person who claims there is a slim chance that said company can arrest hairloss, despite all evidence thus far indicating it can do just that.

• People who argue that JAK inhibitors will cure hairloss, but fail to provide an explanation as to how this will regenerate the hair follicle organ and actually believe that a topical will work for Androgenetic Alopecia because "it can better reach the follicle" and somehow still believe this when shown actual scientific studies that oral JAK (much like finasteride and other drugs) has absolutely no problem reaching the follicle and toward the outermost skin.

When it comes to New Research, there are many who are downright ideologues to whom facts do not matter.

They want to wallow in self pity and believe nothing is happening and it won't matter what breakthroughs happen or how many successful trials we see — they'll still say the same things.

Pithikas explained his "feeling". It's some posts later.
As about RCH-01 itself, if it, indeed, is so good at halting hairloss, why aren't any other companies buying it, except for Shiseido?
Nevertheless, why is it bad that people are skeptical or dubious about new treatments?
We need solid evidence, and we've been provided with very little so far.
Why is it bad that there are pessimists posting their thoughts?
Out there, in the real world, there are optimists, realists and pessimists.
Shouldn't this forum be a reflection of reality, in your opinion?
Why not, That Guy?
Why not?

 

[Xander94]

Pithikas explained his "feeling". It's some posts later.
As about RCH-01 itself, if it, indeed, is so good at halting hairloss, why aren't any other companies buying it, except for Shiseido?
Nevertheless, why is it bad that people are skeptical or dubious about new treatments?
We need solid evidence, and we've been provided with very little so far.
Why is it bad that there are pessimists posting their thoughts?
Out there, in the real world, there are optimists, realists and pessimists.
Shouldn't this forum be a reflection of reality, in your opinion?
Why not, That Guy?
Why not?

Because we are already depressed as is. We dont need more pessimism in our lives

 

[Royaume]

Pithikas explained his "feeling". It's some posts later.
As about RCH-01 itself, if it, indeed, is so good at halting hairloss, why aren't any other companies buying it, except for Shiseido?
Nevertheless, why is it bad that people are skeptical or dubious about new treatments?
We need solid evidence, and we've been provided with very little so far.
Why is it bad that there are pessimists posting their thoughts?
Out there, in the real world, there are optimists, realists and pessimists.
Shouldn't this forum be a reflection of reality, in your opinion?
Why not, That Guy?
Why not?

Because pessimists can f*uck themselves. Pessimists like Kevins who are registered since 2009 have lost any hope and they are desperate af which I absolutely understand. What I don't understand is thT exactly these fkcing pessimists try spread their negativity.

You are sad, unmotivated and desparate? Keep it for yourself. If you have some reasonable questions as we all have then ask it but stop with this attitude: Nothing will happen, no new treatment blah blah blah blah blah.

We all have questions and this is good. Even I have many questions concerning Shiseido and Brotzu but do I spread negativity? no I am not. Learn from it or leave you negative bastards xD

 

[Michel F. II]

Because we are already depressed as is. We dont need more pessimism in our lives

But that's your problem.
It's you who has to cope with it.
Besides, if you can't stand sb's pessimism, just have him on ignore.
It can't be simpler.

 

[That Guy]

As about RCH-01 itself, if it, indeed, is so good at halting hairloss, why aren't any other companies buying it, except for Shiseido?

Shiseido didn't "buy" it; they licensed it. A company can only license what the rights holder is willing to license.

This question can easily be flipped onto the other side of the coin: Why would Shiseido, one of the oldest and largest cosmetic firms in the world, license the technology and invest their own money and capital into building a cell-cultivating facility for a product that doesn't work?

Nevertheless, why is it bad that people are skeptical or dubious about new treatments?

It's not; retarded claims that fly in the face of any fact are.

We need solid evidence, and we've been provided with very little so far.

No, the FDA and the equivalent administrations need evidence; any data that gets released to the public is really just a bonus.

Do you really think that the third-party analysts who analyzed their data lied to them? Or that the company is just going to bullshit the FDA? They won't get away with it anyway and it would destroy the potential future of a company that as of right now, is not a revenue-generating company.

You're a scientific guy, so surely I don't have to explain Occam's razor?

Shouldn't this forum be a reflection of reality, in your opinion?

I'm guessing you haven't visited many subforums here if you expect it to be a reflection of reality instead of the distortion of it that it often is.

 

[Michel F. II]

Because pessimists can f*uck themselves. Pessimists like Kevins who are registered since 2009 have lost any hope and they are desperate af which I absolutely understand. What I don't understand is thT exactly these fkcing pessimists try spread their negativity.

You are sad, unmotivated and desparate? Keep it for yourself. If you have some reasonable questions as we all have then ask it but stop with this attitude: Nothing will happen, no new treatment blah blah blah blah blah.

We all have questions and this is good. Even I have many questions concerning Shiseido and Brotzu but do I spread negativity? no I am not. Learn from it or leave you negative bastards xD

Being a pessimist does not necessarily equate to being sad, unmotivated and desperate.
Some people have been active in such fora way longer than us and have been met with negation of their hopes thus far. It's completely reasonable that they be pessimistic.