There is no functional difference in scalp AR and prostate AR. Agreed, it would be amazing to have direct topical studies with Bica for Androgenetic Alopecia. Unfortunately, these don't exist (as far as I know) and they probably will never happen. So, we will have to do with extrapolation and existing research. This study is probably as good as it gets in terms of clinical results in humans outside prostate cancer. For me, this is pretty damn convincing that Bica is safe and effective in androgen-mediated disease directly targeted at hair follicles (PCOS). There is no reason to assume that Bica won't work topically, since it's not a prodrug and has no active metabolites. There are positive preliminary results with topical Proxilutamide, a very similar analog. Note that I don't make any strong claims about results or hair counts. I still believe that topical AR antagonists will only provide maintenance at best. I just stated that Bica would be a superior option to RU, both in terms of effectiveness and safety.
Define many people. If your pool is people with very aggressive hair loss, then sure. For the general population, an AR antagonist with sufficient binding properties, a sufficiently long half-life in a sufficiently large concentration should provide maintenance, at least for Androgenetic Alopecia.
In deed, Bica's strength mainly lies in the long half-life. However, it should also be stronger than RU in terms of binding capacity (Ideal states 3x stronger, but these calculations are not that exact. I would say it is at least similar in affinities, and possibly slightly better). I think that RU twice a day should be just as effective as Bica, but with a diminished/unestablished safety profile. Keep in mind I am not specifically vouching for Bica. Any AR with comparable properties is a good option to consider. I can't find the comparison between Bica and RU in the paper you linked. Is it the correct paper? Could you maybe post a screenshot? Thanks!
Great post. At some point you just have to let it go and live your life. Settling for a good regimen and try to stop tinkering and overthinking.I just want everyone to read this as it is in my opinion most valuable “info” here actually. I had more “success” from ssri than my hairloss treatments because I dont obsess anymore and do not even look at my hair. Some of you really chasing that high with wanting a perfect nw0 and it has nothing to do with being or not being bald at this point, its just BDD. Get off the forums for a while and live your life.
Attached the full text and screenshot of the referenced text.
Maybe. But since people with aggressive baldness, who were not helped by Finasteride and Dutasteride, decide on Bicalutamide, we have a sample of just such people. And if someone has been helped by a 5Ar inhibitor, then he does not need to use Bicalutamide.
Baldness is terrifying because when it is not stopped, you understand that it will continue until you have no hair left. It is frightening with its perspectives. I have never had a Norwood 1 again, my baldness has never been noticed by others. However, I was very nervous because I was looking to the future.
I am critical of how I look and generally aesthetics. So, of course, becoming a freak is killing me from the inside out. Luckily I escaped it and I feel good
You, too, look after your appearance and want to look your best. This is fine. If you turned into a freak, it could break you. It is worth mentioning that I have the worst scalp shape for baldness, so in my case it would be terrible. I love my hair, and losing something dear is terrible.
Yes, that's so much. Especially Nizoral, lol
Report it on the incel forum, I'm not interested. I am concerned about my perception of myself, and not someone else's.
Maybe I'll show my face. If you're so anxious to see me, perhaps I could send it to you in person.
in this case, you do not understand anything about baldness. And you seriously think that someone with no hair problems is starting to take AA and read this forum. Just retarded. People like you think that I do not have baldness. But what does it matter?
There are no opinions. There are correct and incorrect treatment regimens, the presence of a diagnosis or lack of it. But you like to attribute mental disorders to people and talk about your successes with 18-year-old models while I come here just out of boredom. Are you sure I have the problem and not you? I'm great.
0.025%
Jeju might know
@Jeju Hey mate, do you have any experience with topical Progesterone?
How is it going? Are you seeing any hair regrowth yet?
Improved length is always a good sign with those kind of hairs (I call these areas the “perforated zone”). Have you made any recent changes to your regimen? Or perhaps lifestyle in general?
Only notable changes made going back a reasonable timeframe was back in mid October I added 1.25mg OM and 25mg bicalutamide, early in September I switched from oral estradiol to inejctions and added 18mg boron. Dropped spironolactone when I got on bica. Wasn't experiencing any side effects on OM (not even increased body hair) so in the last week-week and a half I've been doing 2.5mg OM. But there hasn't been enough time on that for it to have really had an effect (on the increased dose, I mean). Also a couple days ago I added 0.5% WAY-200070 to help promote longer anagen, but again not enough time has passed for that to be having an effect. Only other thing I've changed is really more of a lifestyle thing- went from using a centrum multivitamin to one from Life Extension like a month ago. Doubt that could be causing this however, just noting it for posterity's sake.
My suspicion is likely oral minoxidil, it’s a growth stimulant and seems to do a good job at promoting growth in those shorter hairs. Obviously the increased dose isn’t quite responsible, but the fact you recently started it as opposed to not having it at all is probably the difference maker. It is super powerful and likely creates an exponential effect on your other treatments (perhaps the vasodilation allows more E, and etc, to reach the tissues).
From what I’ve been seeing, it seems like E2 doesn’t really affect hair at 1-2mg, just causes sides and gyno. A dose of 4-6mg seems to be what provides results for hair. Bica seems to be the same way with its dosages. It appears that CPA is still somewhat effective at lower dosages though, but has pronounced sides (AnxiousAndy has results on it). spironolactone seems nearly useless, unless you are female then maybe it has somewhat of a synergistic effect with those particular sexual characteristics.
