Exploring The Hormonal Route. Hair=life.

[Adri23]

Ok, but that doesn't mean u can say that all the cases are false and that it's all advertising.

I never said that, you came here with a normie regimen bothered by feminization regimens. You clearly belong to r/tressless my guy

 

[Ryuzaki hedeki]

Hi all, looking to get some guidance on the various forms of estradiol. I've looked through a lot of the pages on this thread, but looking for the latest thinking. I'm a cis 43 yo man with some diffused thinning:

17-alpha-estradiol: is there any thinking that this can be negative on hair? i've recently added 0.1% to my regime (it's weak, so thought i'd increase it above the 0.025% dose that's used in a lot of commercial solutions) but seem to have experienced a bit of thinning since i added it (hair had been stable for years... this was the only thing i added to my daily stack).

17- beta- estradiol: if added a very low % e.g. 0.05% (0.5mg per ml) will this likely improve my hair situation, or is there a risk that it may have a negative effect? Ignoring risk of side-effects.

Estriol: what's the latest thinking on whether this can help improve AA hair loss at say 0.5% (5mg per ml)?

Thanks

If you have been a diffuse thinner for years, then you will need a full shemale regimen. Keep in mind Luck plays a major role as well, that guy bridge was extremely lucky to had this come back after years of baldness.

 

[exwhyyou]

hairlosstalk users: i am going to spend every waking moment of my life complaining about my balding situation but i refuse to take any risks whatsoever on growing gyno.

trans women: i don’t care about going bald. i will just wear a wig. give me this dht drug so i can grow the absolute most massive boobs i possibly can.

 

[cornscoops]

Should you wait for the breast to grow all the way before removal or should you get gyno surgery as soon as you see it

 

[losingbattle88]

Should you wait for the breast to grow all the way before removal or should you get gyno surgery as soon as you see it

I rather be bald like god intendend

 

[Dav1234]

Everyone I’ve asked says to use estrogen injections enethate or cypionate but I’m from the states and on good rx I only see estradiol valerate.

 

[losingbattle88]

God intended you to be a woman and that's why you're attracted to men. Homosexuality is unnatural and disgusting. Fix his mistake and get on estrogen as soon as possible. Your balding is just another sign to transition

Lol so I will turn straight on estrogen?? I will turn into a woman and suck dick right?? U cant change your gender dude. I will still be a man and gay just like you. I dont ever wanna look or be a woman. Thats not my desire. And I dont know why adri likes your comment. Seems like he likes being a tranny too.

 

[Get my hair back]

I wonder why no one uses E4 (Estetrol), its security profile is better compared to E2. However, it is much weaker than estradiol. But I'm a little perplexed, its affinity with ERß is several times higher than with ERa. Did I understand correctly? https://pmc.ncbi.nlm.nih.gov/articles/PMC8566418/

 

[Adri23]

I wonder why no one uses E4 (Estetrol), its security profile is better compared to E2. However, it is much weaker than estradiol. But I'm a little perplexed, its affinity with ERß is several times higher than with ERa. Did I understand correctly? https://pmc.ncbi.nlm.nih.gov/articles/PMC8566418/

Harder to get, more expensive than e2 and prob you have to use it daily. On the other hand e2 is very cheap, one injection per week and very widely available.

 

[Adri23]

I think most ppl overthink about the gyno. Once you get it you stop care, I can promise you. I was the same I was so worried about gyno like trust me so worried and scared. After my boobs got bigger I stopped care.

 

[losingbattle88]

I think most ppl overthink about the gyno. Once you get it you stop care, I can promise you. I was the same I was so worried about gyno like trust me so worried and scared. After my boobs got bigger I stopped care.

Wether that is estrogen making u want or feel more like a woman. Or u stopped caring. I still doubt u enjoy your reflection. I rly wonder what your dad and mom think of your breasts and being on HRT for hair. or your siblings and co workers or school class mates or friends. Its just all too weird. I wouldnt be able to handle the shame personally.

 

[Get my hair back]

I don't know about you, I personally take E solely for hair growth.
Estetrol has a number of advantages over other estrogens.
First of all, it interests me because it binds mostly to ERß, which are the receptors responsible for hair growth.
The bioavailability of E4 when taken orally is 90%, compared to 10% for E2.
The half-life of E4 in humans is 28-32 hours, which allows it to be taken once a day.
E4 is the ultimate estrogen - it is not metabolized and is excreted in its pure form.
The risk of side effects is much lower than E2. And it won't grow boobs like E2.
It also helps rejuvenate the body https://pubmed.ncbi.nlm.nih.gov/23992378/
Crucially, unlike estradiol, E4 does not convert to hydroxylated metabolites that can damage DNA - so it will not contribute to breast cancer development
Estetrol does not increase the production of sex hormone-binding globulin (hsGH) by liver cells to the same extent as other estrogens.
This is a unique characteristic of E4 because only non-protein-bound estrogens are biologically active and able to reach target tissues.

E4 demonstrates minimal effects on hepatic metabolism, hemostasis, lipids, renin-angiotensin system and mammary gland. It has a low risk of inter-drug interactions and is not involved in enterohepatic recirculation. E4 is referred to as the first natural estrogen with selective tissue activity.

We all know that hair grows much better in pregnant women, maybe because E4 is produced exclusively during pregnancy and is found from the 9th week of pregnancy in maternal urine and from the 20th week in maternal plasma. E4 levels in maternal plasma increase during pregnancy and reach 1 ng/mL (3 nM) by the second trimester. Fetal plasma E4 levels are 12 times higher than maternal levels at term pregnancy. Could the amazing hair growth during pregnancy be due to this?

It's not hard to buy where I live.

 

[losingbattle88]

I don't know about you, I personally take E solely for hair growth.
Estetrol has a number of advantages over other estrogens.
First of all, it interests me because it binds mostly to ERß, which are the receptors responsible for hair growth.
The bioavailability of E4 when taken orally is 90%, compared to 10% for E2.
The half-life of E4 in humans is 28-32 hours, which allows it to be taken once a day.
E4 is the ultimate estrogen - it is not metabolized and is excreted in its pure form.
The risk of side effects is much lower than E2. And it won't grow boobs like E2.
It also helps rejuvenate the body https://pubmed.ncbi.nlm.nih.gov/23992378/
Crucially, unlike estradiol, E4 does not convert to hydroxylated metabolites that can damage DNA - so it will not contribute to breast cancer development
Estetrol does not increase the production of sex hormone-binding globulin (hsGH) by liver cells to the same extent as other estrogens.
This is a unique characteristic of E4 because only non-protein-bound estrogens are biologically active and able to reach target tissues.

E4 demonstrates minimal effects on hepatic metabolism, hemostasis, lipids, renin-angiotensin system and mammary gland. It has a low risk of inter-drug interactions and is not involved in enterohepatic recirculation. E4 is referred to as the first natural estrogen with selective tissue activity.

We all know that hair grows much better in pregnant women, maybe because E4 is produced exclusively during pregnancy and is found from the 9th week of pregnancy in maternal urine and from the 20th week in maternal plasma. E4 levels in maternal plasma increase during pregnancy and reach 1 ng/mL (3 nM) by the second trimester. Fetal plasma E4 levels are 12 times higher than maternal levels at term pregnancy. Could the amazing hair growth during pregnancy be due to this?

It's not hard to buy where I live.

Freak.

 

[Almas_NW0]

I rather be bald like god intendend

There is no God, you just resigned yourself and took the path of least resistance.

 

[Almas_NW0]

Wether that is estrogen making u want or feel more like a woman. Or u stopped caring. I still doubt u enjoy your reflection. I rly wonder what your dad and mom think of your breasts and being on HRT for hair. or your siblings and co workers or school class mates or friends. Its just all too weird. I wouldnt be able to handle the shame personally.

No one will know unless you tell them.

 

[Adri23]

Wether that is estrogen making u want or feel more like a woman. Or u stopped caring. I still doubt u enjoy your reflection.

I dont really care about my reflection cause as I said you get used to it eventually. It is kinda weird the first month or so but after that you forget about it.

I rly wonder what your dad and mom think of your breasts and being on HRT for hair. or your siblings and co workers or school class mates or friends. Its just all too weird. I wouldnt be able to handle the shame personally.

They rly don't care either. Rejecting someone for his physique is just ridiculous. Also it's not good to constantly overthink about what other people think about you, it will run you crazy. My parents and sister has seen my gyno several times and they dont care much. They was kinds surprised at first but they eventually stopped caring too

 

[Adri23]

I don't know about you, I personally take E solely for hair growth.
Estetrol has a number of advantages over other estrogens.
First of all, it interests me because it binds mostly to ERß, which are the receptors responsible for hair growth.
The bioavailability of E4 when taken orally is 90%, compared to 10% for E2.
The half-life of E4 in humans is 28-32 hours, which allows it to be taken once a day.
E4 is the ultimate estrogen - it is not metabolized and is excreted in its pure form.
The risk of side effects is much lower than E2. And it won't grow boobs like E2.
It also helps rejuvenate the body https://pubmed.ncbi.nlm.nih.gov/23992378/
Crucially, unlike estradiol, E4 does not convert to hydroxylated metabolites that can damage DNA - so it will not contribute to breast cancer development
Estetrol does not increase the production of sex hormone-binding globulin (hsGH) by liver cells to the same extent as other estrogens.
This is a unique characteristic of E4 because only non-protein-bound estrogens are biologically active and able to reach target tissues.

E4 demonstrates minimal effects on hepatic metabolism, hemostasis, lipids, renin-angiotensin system and mammary gland. It has a low risk of inter-drug interactions and is not involved in enterohepatic recirculation. E4 is referred to as the first natural estrogen with selective tissue activity.

We all know that hair grows much better in pregnant women, maybe because E4 is produced exclusively during pregnancy and is found from the 9th week of pregnancy in maternal urine and from the 20th week in maternal plasma. E4 levels in maternal plasma increase during pregnancy and reach 1 ng/mL (3 nM) by the second trimester. Fetal plasma E4 levels are 12 times higher than maternal levels at term pregnancy. Could the amazing hair growth during pregnancy be due to this?

It's not hard to buy where I live.

Being oral kills all the hype for me. I wont ever take e2 or e4 or whatever daily, I like the weekly injections way too much.

Also not increasing SHBG wouldnt be that good IMO. SHBG acts as a natural antiandrogen, even if you have somewhat high total androgens the SHBG makes them less bioavailable thus less usable for the body. I think SHBG has prevented me from being fully ball right now.

You still havent said the price but I rly doubt it would be cheaper than DIY injections, I think nothing cant get cheaper than that.

 

[losingbattle88]

No one will know unless you tell them.

Right. Its easily visable with a normal sized shirt. Have fun with your baggy clothes you clown. xD hiding with baggy clothes is being insecure. How will it be when you have sex? Sex with clothes on btw lololol.

 

[losingbattle88]

There is no God, you just resigned yourself and took the path of least resistance.

Sorry let me correct it. "As nature intended"

 

[Adri23]

Tbh you still have surgery in case you really dislike the gyno, but everyone here knows that it's gonna develop anyways so most of us just keep going with life.