It does matter because my dht always gets higher than what bica can inhibit, and with my lo T i start to get Low T symptoms with very high dht. Bica never was a real solution for me sadly.
Also this graph is more acurate.
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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Also this graph is more acurate.
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That seems impossible. If bica was so sh*t that it can't even block DHT that's the main driving force behind prostate cancer. It would have been discontinued long ago
I think u didnt understand my point.... At the dosage i need to supress my dht, my Testosterone would be completely nuked because T is easier to outnumber at like 20 pg/ml while dht at that same level would need bica at like 25 my daily to even have a chance. What I mean is that if I take 25 mg daily my T gets too low and I start to have very low T symptoms and my body start to regulate 5ar1 to give a stronger androgen signaling.
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Might as well not take it then. It's pointless if your receptors are just partially blocked
My levels are perfect it is just the dht. I will megadose dutasteride to see what i can achieve
I have diffuse thinner as well, finasteride wipe out my hair and gave me oily and sebum production. After finasteride I started take 150MG of bicalutamide daily for 4 months. Never worked. After that I started with estrogel for 3 months then moved to injections, 4,8 MG of estradiol valerate every 4 days, took it probably for 5 months. 0 results.
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Also we have not only endocrine system. Our cells also act in a paracrine and autocrine manner. For your cell to produce DHT independently, it only needs cholesterol as a source.
All prostate cancer patients who undergo surgical castration should have a full head of hair, since after this surgery the testosterone level is reduced by 96%. And this clearly does not happen. In aggressive cancers, the tumor (which is androgen dependent) continues to progress, sometimes even more rapidly, even with the 96% reduction in testosterone. Why? Because our cells have the ability to synthesize hormones locally. Paracrine and Autocrine system.
It needs 5 alpha reductase enzyme, otherwise it cant be produced, so megadose with 2.5 mg dutas will get rid of this poisoning hormone
No, im not talking about the endocrine pathern. It also can be synthesized by the nucleus of your cell.
Show me an study that shows dht can be synthetized on the body without 5ar enzyme
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if I recall correctly the enzyme can be produced by the local cell itself, a la paracrine
Wouldn't dutasteride at like dosages of 2.5 mg inhibit that?
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Judging by scalp DHT levels being significantly lower at that dose I would say so (50% vs 85% iirc). I’m also curious if there’s any data on dutasteride at even higher doses? 3mg and beyond might suppress even more locally, to eventually match serum levels.