I don't know about you, I personally take E solely for hair growth.
Estetrol has a number of advantages over other estrogens.
First of all, it interests me because it binds mostly to ERß, which are the receptors responsible for hair growth.
The bioavailability of E4 when taken orally is 90%, compared to 10% for E2.
The half-life of E4 in humans is 28-32 hours, which allows it to be taken once a day.
E4 is the ultimate estrogen - it is not metabolized and is excreted in its pure form.
The risk of side effects is much lower than E2. And it won't grow boobs like E2.
It also helps rejuvenate the body
https://pubmed.ncbi.nlm.nih.gov/23992378/
Crucially, unlike estradiol, E4 does not convert to hydroxylated metabolites that can damage DNA - so it will not contribute to breast cancer development
Estetrol does not increase the production of sex hormone-binding globulin (hsGH) by liver cells to the same extent as other estrogens.
This is a unique characteristic of E4 because only non-protein-bound estrogens are biologically active and able to reach target tissues.
E4 demonstrates minimal effects on hepatic metabolism, hemostasis, lipids, renin-angiotensin system and mammary gland. It has a low risk of inter-drug interactions and is not involved in enterohepatic recirculation. E4 is referred to as the first natural estrogen with selective tissue activity.
We all know that hair grows much better in pregnant women, maybe because E4 is produced exclusively during pregnancy and is found from the 9th week of pregnancy in maternal urine and from the 20th week in maternal plasma. E4 levels in maternal plasma increase during pregnancy and reach 1 ng/mL (3 nM) by the second trimester. Fetal plasma E4 levels are 12 times higher than maternal levels at term pregnancy. Could the amazing hair growth during pregnancy be due to this?
It's not hard to buy where I live.