Exploring The Hormonal Route. Hair=life.

JaneyElizabeth

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I think it is safer to add estradiol to Bica than spironolactone. spironolactone seems to have many unpleasant effects.
I wonder if I'm a cis male, would others be suspicious? Or will I still look like a guy without wearing makeup, but with smoother skin? I don’t want others to suspect anything. I am also wondering if I can preserve male breasts if I remove the gland completely
FWIW. I hear that libido is better on bica, it's better for hair and it has fewer of spironolactone's sides. Only thing is, and it's close, over a lifetime Bica might be more harsh. Bica is also used as a puberty blocker adjunct.
 

Almas

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I really should stop taking bica for that reason, but whos to say lowering androgens in general whoudn't lead to the same fate. I'm about to switch to progesterone and estradiol only.
It's about the sensitivity of cancer cells to Bicalutamide, but if you don't have cancer, your cells don't mutate. I don't know, I'm not sure if this study applies to us
 

keepcoolmybabies

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It's about the sensitivity of cancer cells to Bicalutamide, but if you don't have cancer, your cells don't mutate. I don't know, I'm not sure if this study applies to us
Not necessarily. Mutation isn't the same thing as receptor sensitivity.
 

keepcoolmybabies

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I think it is safer to add estradiol to Bica than spironolactone. spironolactone seems to have many unpleasant effects.
I wonder if I'm a cis male, would others be suspicious? Or will I still look like a guy without wearing makeup, but with smoother skin? I don’t want others to suspect anything. I am also wondering if I can preserve male breasts if I remove the gland completely
A lot of it depends on how you look now in terms of bone structure, etc. There's a decent chance you might just end up looking like a younger guy with nicer skin. But fat redistribution will affect your male attributes in ways that might not be deemed ideal for guys. For instance your jawline will likely soften up and you'll get more cheek fat. And if you don't have especially masculine bone structure as is, then there's a chance you will start looking female given enough time. Personally I didn't feel comfortable presenting female (makeup, clothing, etc) until random strangers began gendering me female while still presenting male. So the possibility to "male fail" exists regardless of presentation in time.
 

keepcoolmybabies

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Is this for AA's in general? I've read things about finasteride preventing prostate cancer-- but in rare cases, it causes more aggressive prostate cancer.
Anytime the receptor is blocked, it can increase sensitivity to compensate. Downregulation and upregulation of receptors happen even just as a result of hormone levels at a given time.
 
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Isneezedsohard

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Anytime the receptor is blocked, it can increase sensitivity to compensate. Downregulation and upregulation of receptors happen even just as a result of hormone levels at a given time.
ugh... I hate that we have to f*** with our hormones just to look and feel like who we really r. Feels like a cruel joke
 

keepcoolmybabies

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ugh... I hate that we have to f*** with our hormones just to look and feel like who we really r. Feels like a cruel joke
The real question is whether or not the increased sensitivity is enough to overcome the meds that inhibit the receptors. In castrate resistant prostate cancer, the increased sensitivity is enough to still fuel the cancer cells. But hairloss (or other androgen dependent traits) might not be as responsive
 

Gergely

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The real question is whether or not the increased sensitivity is enough to overcome the meds that inhibit the receptors. In castrate resistant prostate cancer, the increased sensitivity is enough to still fuel the cancer cells. But hairloss (or other androgen dependent traits) might not be as responsive
Yes but for a male context, on can be much worse off after stopping hrt than before starting it.
 

Isneezedsohard

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But I do wonder if there's someway to edit DNA in a way to not impact general health, but decrease androgen sensitivity. That feels like the key
 

DogoDiLaurentiis

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FWIW. I hear that libido is better on bica, it's better for hair and it has fewer of spironolactone's sides. Only thing is, and it's close, over a lifetime Bica might be more harsh. Bica is also used as a puberty blocker adjunct.

What I want to do is use bica to really help me regain the hair I've lost in conjunction with estrogel, and then taper off and see if I can't manage my hair-gains through estrogen and other means.
 

DogoDiLaurentiis

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But I do wonder if there's someway to edit DNA in a way to not impact general health, but decrease androgen sensitivity. That feels like the key

You're describing CRISPR gene editing, and yes it is a thing but only China is really doing it right now, and it is not commercially available... yet.
 

DogoDiLaurentiis

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ugh... I hate that we have to f*** with our hormones just to look and feel like who we really r. Feels like a cruel joke


Ironically enough think about it like getting a haircut when your hairstyle has become overgrown. All you're doing is manually resetting things which sometimes is necessary.
 

DogoDiLaurentiis

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That's why I wish things like PRP and Stem cells actually worked. It would negate all the negative consequences of these treatments. Then again-- obviously thats just wishful thinking

PRP -can- work but there are too many factors that PRP does not treat.

In my case I'm certain I get on metformin, I get at least 0.75 17b estradiol, and I get on an androgen blocker and I'm set.

What's disgusting is that doctors are reticent to do this, but they'll hand off hormones to ignorant kids who think, as mentioned hormones are nothing but magic fairy dust that will turn them into a beautiful princess without any consequences or challenges.
 

JaneyElizabeth

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What I want to do is use bica to really help me regain the hair I've lost in conjunction with estrogel, and then taper off and see if I can't manage my hair-gains through estrogen and other means.
You are Mr. Tinkerer. Go for it. We are all just Sisyphus's after our hair and that is endearing to me. The guys who get all excited about pig something or other but they are really into it and hoping. Have I seen your hair? I understand if you don't show. Before, showing my scalp was like showing my genitals. It was too painful but I want to post my recovery.
 

DogoDiLaurentiis

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You are Mr. Tinkerer. Go for it. We are all just Sisyphus's after our hair and that is endearing to me. The guys who get all excited about pig something or other but they are really into it and hoping. Have I seen your hair? I understand if you don't show. Before, showing my scalp was like showing my genitals. It was too painful but I want to post my recovery.

I've shown my hair once after the first recovery. I'm looking to get there once more, but I'm pretty well at a plateau in terms of what I can do with what I have. I'm waiting on my estrogel to come in the mail, I'm going to have to be more forceful with my doctor next month when I see them about the metformin and make it very clear I'm not trying to go the gentle path.

I should have just flat out told them that this was about saving my hair, because frankly that's the only thing that matters to me outside of other superficial matters. I'm not not sure as to whether I should order bica or diane35. However it has become obvious to me that more extreme measures must be taken to force my hair.

I can smell my pits and I have a "hormonal" testosterone smell to them which I never ever had when I had a full head of hair. Meaning my traditional methods of curtailing testosterone are not working. I may also just go into my doctor's office early and tell them I'm sick of dealing with this and I want to be on something that lowers my test.

I can only take so much beta sitosterol and I feel like it's seriously cutting into my estrogen production, and there's just absolutely zero zero zero way I'm ever going on finasteride ever again.
 

JaneyElizabeth

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I've shown my hair once after the first recovery. I'm looking to get there once more, but I'm pretty well at a plateau in terms of what I can do with what I have. I'm waiting on my estrogel to come in the mail, I'm going to have to be more forceful with my doctor next month when I see them about the metformin and make it very clear I'm not trying to go the gentle path.

I should have just flat out told them that this was about saving my hair, because frankly that's the only thing that matters to me outside of other superficial matters. I'm not not sure as to whether I should order bica or diane35. However it has become obvious to me that more extreme measures must be taken to force my hair.

I can smell my pits and I have a "hormonal" testosterone smell to them which I never ever had when I had a full head of hair. Meaning my traditional methods of curtailing testosterone are not working. I may also just go into my doctor's office early and tell them I'm sick of dealing with this and I want to be on something that lowers my test.
I mean, I don't know your age and your hopes to marry but if you are young, consider banking sperm because this side of the fence is pretty nice. My fear is that we can't find a cis-male dosage that won't grow breasts. If you go lower, the body thinks it is time for first period. I never let anyone in 36 years approach me from behind when I am seated because I had an incipient bald spot and people would like finger it and say, you are going bald. finasteride/min maintained that incipient bald spot for a long time but then I had one of those things where I lost my looks overnight. I have some on my blog but it's hard to have that happen. My alter-ego was just worn out and he was done. So Janey took over. He looked so ill before I went on HRT. I must have had a real imbalance of T and DHT.
 

keepcoolmybabies

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PRP -can- work but there are too many factors that PRP does not treat.

In my case I'm certain I get on metformin, I get at least 0.75 17b estradiol, and I get on an androgen blocker and I'm set.

What's disgusting is that doctors are reticent to do this, but they'll hand off hormones to ignorant kids who think, as mentioned hormones are nothing but magic fairy dust that will turn them into a beautiful princess without any consequences or challenges.
You said you would stay off that topic. I agree that it's bs that doctors might be hesitant to prescribe hrt meds for hairloss in males if that's what they seek and as such it should be informed consent. But can you not make that point without the knock on trans issues? I would argue that they don't do what you are suggesting and that it requires a lot more gatekeeping. And that the people who make those decisions likely know more about themselves than you or I do (just like you know that you want hair and are willing to use female hormones for it, even if some would think that means you're crazy). But you would obviously disagree. So what's the point to keep doing this. I'll gladly talk hair loss stuff with you and others here. Just please try and refrain from veering in this direction since it's not constructive.
 
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