Exploring The Hormonal Route. Hair=life.

[Nimos0651]

spironolactone is arguably the safest for the liver but it has the heaviest sides in the short-run.

What sides did you experience? I currently take 50mg a day and will be bumping it up to 100mg in 1 week. (havent noticed any sides yet)

 

[Nimos0651]

Bicalutamide is not as dangerous for the liver as you think. This is not something to worry about. I'm more interested in which of the two options is more efficient and safer. The advantage of Bicalutamide is that it does not interfere with muscle building

What source or study indicates that it does not interfere with muscle building?

 

[Almas]

What source or study indicates that it does not interfere with muscle building?

I am not keeping links to research. Search Wikipedia for links to research.

 

[Almas]

Other thing is, why do people even care about muscle building when they will grow breasts on top of them.

Surgery.

 

[Nimos0651]

I am not keeping links to research. Search Wikipedia for links to research.

How long have you been on 50mg bica? how severe is your hairloss?

 

[Almas]

Ikarus uses 2mg estradiol. If using Estrogel, how many taps do I need to do to get 2mg of estradiol? Is 2 clicks enough? Estrogel is the cheapest and most convenient to use: I can just smear my forearms, one press on the right and left

 

[Almas]

How long have you been on 50mg bica? how severe is your hairloss?

Less than a month. I have aggressive baldness, my hair is thinning, my temples are receding. I have terrible genetics. I'm not sure if 50mg of Bicalutamide will stop this, so I'm preparing a plan B in advance

 

[Pls_NW-1]

Less than a month. I have aggressive baldness, my hair is thinning, my temples are receding. I have terrible genetics. I'm not sure if 50mg of Bicalutamide will stop this, so I'm preparing a plan B in advance

I think you need 150mg

 

[Almas]

I think you need 150mg

75-150, yes. But I will hope for a miracle and slowly increase the power of healing, including in order to conduct research for this forum.

 

[Nimos0651]

Less than a month. I have aggressive baldness, my hair is thinning, my temples are receding. I have terrible genetics. I'm not sure if 50mg of Bicalutamide will stop this, so I'm preparing a plan B in advance

Ive been on my new regimen for 3.5 weeks so it is way too early to tell. Im giving it 6 months before trying anything else (slowly increasing my doses if I dont see any sides)

 

[Pls_NW-1]

No, 50mg blocks PSA by 90%. If he loses hair on that it's just better to go full mtf protocol for health, beacuse he will fall apart without any main sex hormone.

But bica wont deplete sex hormones, I don't understand.

 

[Pls_NW-1]

75-150, yes. But I will hope for a miracle and slowly increase the power of healing, including in order to conduct research for this forum.

Power of healing!? Wdym?

 

[Pls_NW-1]

It will stop androgens from binding, so they will not cause androgenic functions in the body from what I understand. If you block 90% of your androgens from binding, its already terrible for your body.

Sadly this is the only way for some to even just maintain for a couple of years tf.

A "cure" /cloning seems also not very likely for future. We will just be bald sooner or later.

 

[Pls_NW-1]

Yeah, but if hair is so important for you, its better to be healthy person otherwise. Taking huge doses of AA that will block your androgenic functions, and not suplementing your body with estrogen will be bad for your health. You have be either in healthy female levels or male levels and taking 150mg bica will not put you in either.

I'm feeling pretty desperate. Don't know what to do.

 

[Almas]

Yeah, but if hair is so important for you, its better to be healthy person otherwise. Taking huge doses of AA that will block your androgenic functions, and not suplementing your body with estrogen will be bad for your health. You have be either in healthy female levels or male levels and taking 150mg bica will not put you in either.

Testosterone does not need to bind to androgen receptors to function properly. Bicalutamide causes problems if you are castrated. evidence of cardiovascular diseases occurred only in patients who were taking Bicalutamide with leutenizing hormone receptor antagonists or GNRH analogs

Bicalutamide and cardiovascular disease Bicalutamide is currently the most frequently used antiandrogen, both alone or in combination with GnRH agonists, in order to obtain complete androgen blockade (CAB), mainly owing to the higher cardiotoxic adverse effects, observed with the use of steroidal agents. Bicalutamide was not classified in CredibleMeds (https://www.crediblemeds.org/ index.php / login / dlcheck), an online database of drugs known to prolong QT interval and induce TdP, directly or indirectly. Data, regarding the effect of total androgen blockade (GnRH antagonist / agonist associated with androgen receptor inhibitors) in terms of rhythmic risk are lacking and need further investigation.
However, to date, several observational studies did show data, regarding the CV toxicity of bicalutamide [25, 38, 39, 51]. The results obtained from these studies demonstrated that the use of bicalutamide alone did not increase the incidence of stroke or the risk of any type of fatal and nonfatal CVD, as compared with GnRH agonist, antagonist, or orchiectomy.
These findings support the concept that alteration of systemic androgen levels may be critical for the development of CVD, whereas treatments affecting just the AR biology probably do not confer increased CVD risks. Indeed, bicalutamide does not reduce the circulating testosterone, which provides an adequate arterial compliance and metabolic regulation.
Interestingly, as previously shown, CAB was associated with an increased risk (HR 1.6 [1.3–2.0]) of hospitalizations for ischemic events (myocardial infarction or ischemic stroke), as compared with GnRH agonist alone [51], suggesting a higher CV toxicity when combining GnRH analogs with bicalutamide.

 

[Pls_NW-1]

Testosterone does not need to bind to androgen receptors to function properly. Bicalutamide causes problems if you are castrated. evidence of cardiovascular diseases occurred only in patients who were taking Bicalutamide with leutenizing hormone receptor antagonists or GNRH analogs

Bicalutamide and cardiovascular disease Bicalutamide is currently the most frequently used antiandrogen, both alone or in combination with GnRH agonists, in order to obtain complete androgen blockade (CAB), mainly owing to the higher cardiotoxic adverse effects, observed with the use of steroidal agents. Bicalutamide was not classified in CredibleMeds (https://www.crediblemeds.org/ index.php / login / dlcheck), an online database of drugs known to prolong QT interval and induce TdP, directly or indirectly. Data, regarding the effect of total androgen blockade (GnRH antagonist / agonist associated with androgen receptor inhibitors) in terms of rhythmic risk are lacking and need further investigation.
However, to date, several observational studies did show data, regarding the CV toxicity of bicalutamide [25, 38, 39, 51]. The results obtained from these studies demonstrated that the use of bicalutamide alone did not increase the incidence of stroke or the risk of any type of fatal and nonfatal CVD, as compared with GnRH agonist, antagonist, or orchiectomy.
These findings support the concept that alteration of systemic androgen levels may be critical for the development of CVD, whereas treatments affecting just the AR biology probably do not confer increased CVD risks. Indeed, bicalutamide does not reduce the circulating testosterone, which provides an adequate arterial compliance and metabolic regulation.
Interestingly, as previously shown, CAB was associated with an increased risk (HR 1.6 [1.3–2.0]) of hospitalizations for ischemic events (myocardial infarction or ischemic stroke), as compared with GnRH agonist alone [51], suggesting a higher CV toxicity when combining GnRH analogs with bicalutamide.

So you say bica alone is "good"? Lol

 

[Almas]

So you say bica alone is "good"? Lol

I think Bicalutamide is safe

 

[Pls_NW-1]

I think Bicalutamide is safe

What do you think about ADT affecting health, such as bone mass (density), muscles, heart and other essential organs?...

 

[Almas]

What do you think about ADT affecting health, such as bone mass (density), muscles, heart and other essential organs?...

It has bad health effects if it includes castration and GNRH. Bicalutamide alone does not lead to such problems and is not the complete ADT that is meant when talking about prostate cancer

 

[Pls_NW-1]

It has bad health effects if it includes castration and GNRH. Bicalutamide alone does not lead to such problems and is not the complete ADT that is meant when talking about prostate cancer

Are you planning to stay on bica like - for ever?