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hmm nice idea tbh, do u think i should drop dutasteride before i do it??
Exploring The Hormonal Route. Hair=life.
- Thread starter bridgeburn
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No, that's the one you have to stay on or this won't even conceptually work except for the power of stasis.
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My hair is coming in and growing pretty fast but I still need more volume. That usually comes with the refinements in silkiness and manageability.
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I need to keep titrating downward in oral min though because my face has gone from smooth to rough even though it doesn't grow out anymore.
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Oral versus Transdermal Estradiol in Feminising Hormone Therapy for Transgender Individuals
Oral versus Transdermal Estradiol in Feminising Hormone Therapy for Transgender Individuals by Sam
transfemscience.org
No apparent differences.
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Sources/Excerpts: Reviews, Cohort Studies and Randomised Controlled Trials Comparing the Feminising Efficacy of Estradiol Administered by Oral and Non-Oral Routes
Sources/Excerpts: Reviews, Cohort Studies and Randomised Controlled Trials Comparing the Feminising Efficacy of Estradiol Administered by Oral and Non-Oral Routes by Sam
transfemscience.org
I find it startling that all of the different ingestion methods for E2 work exactly the same except for liver effects. It's like just use enough estradiol and all of this will be sorted out....Have faith sayeth Goddess above....
I don't think that's how bica works. I thought it essentially blocked off T from binding to the AR, without suppressing serum levels. Correct me if I'm wrong.
@Pls_NW-1 , are you doing this stuff topically or orally? I am not very familiar with these powerful AAs.
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I always say that it spoofs lower T while provera actually lowers T in fact while not having any sides for me, nor does 300mg of P4 daily.
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Only to the extent that I know it exists. There's very little demand in the MtF world. I think that there are also estrone tabs and those would be worth a try but I never see them for sale on my list of offshore sites. Ovestin might be the brand name. It says it will work fine for feminization but you have to use tons. I don't think that it works well as a hair loss med but it works great for breast growth when unopposed. And if you are like, oh, doesn't it lessen breast growth, well no, not when used at levels that mimic the start of puberty.
I have tried and tried to find you guys an intermediate path and I haven't found one yet. I will try to look into Serms but they cost a lot pounds and even dollars and Euros and you have to balance this concern by knowing that very few go much past the gyno stage or a double A cup. I never thought that I would be giving advice that needed reference to bra sizes but you gotta go with the flow said she.
Estriol (medication) - Wikipedia
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A topical version of these AAs sounds reasonable but I really don't like the idea of systemically blocking off ARs. There are some in the brain and heart. For these reasons I think Janey is pretty smart by leaning more towards estrogen as a primary systemic AA. I mean, sure I bet taking those AAs orally would help but I think the long term risks are insane.
@Almas
en.m.wikipedia.org
en.m.wikipedia.org
*Bica does not supress Testo like CPA for example. Is a non-steroidal AntiAndrogen. It is a completely selective antagonist of the AR. Instead, it increases T thus the conversion of T into E2 via aromatase enzyme, that's why Gyno it's the most common side effect of Bica. Just posting this to help. Thank you.
https://www.hairlosstalk.com/interact/threads/safest-antiandrogen-for-your-dick-bicalutamide.123190/
Pharmacology of bicalutamide - Wikipedia
Bicalutamide - Wikipedia
*Bica does not supress Testo like CPA for example. Is a non-steroidal AntiAndrogen. It is a completely selective antagonist of the AR. Instead, it increases T thus the conversion of T into E2 via aromatase enzyme, that's why Gyno it's the most common side effect of Bica. Just posting this to help. Thank you.
Thanks. Yeah my guess is that you still need a solid AA regimen for it to work. From what I understand, the reason estradiol seems better at growing hair (and all things feminine) is that it is a much stronger AA than estriol. So people could likely get away with estradiol alone. The thing about estriol is that it doesn't seem to grow breasts, however it is apparently highly correlated with hair. Just too weak on its own.Only to the extent that I know it exists. There's very little demand in the MtF world. I think that there are also estrone tabs and those would be worth a try but I never see them for sale on my list of offshore sites. Ovestin might be the brand name. It says it will work fine for feminization but you have to use tons. I don't think that it works well as a hair loss med but it works great for breast growth when unopposed.
Estriol (medication) - Wikipedia
en.wikipedia.org
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Bicalutamide acutally doesn't block the AR, more-over it binds to a socket, which is attached to the AR to block the expression of the AR gene and its' information.
Because of that, anabolic conditions, like muscles etc, won't be affected by the usage of Bicalutamide. Only the rising E levels could harm muscles.
In conclusion: Bicalutamide stops androgens in the body to work and express androgenic information from genes. Genes for the growth of tumoric prostatic cancer cells, or even the genes to miniaturize the follicles.
And because of the blockage, Bicalutamide lets the androgen levels in the body rise, the brain thinks that the body needs more androgens, thus accelerating T production (+30-80%). The excessive T will be then aromatized to E, AND thats again why some MtF use bica.
No, I am not, well, not yet. I can't take that stuff just yet. My doctor won't allow me I think because of my age. I may get it prescribed when I'm 18, or I tell that I am non-binary lol.
I will take it orally, as topically it won't work efficiently enough as orally. I remember a user taking this stuff topically, and he experienced a change, but as well the normal ADT (Androgen-Deprivation-Therapy) effects, like gynecomastia.
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You know your stuff as I could barely follow that. We just have to remember that categorical statements in the HRT world are hard to make, particularly in terms of effects and when they come on.@Almas
https://www.hairlosstalk.com/interact/threads/safest-antiandrogen-for-your-dick-bicalutamide.123190/Pharmacology of bicalutamide - Wikipedia
Bicalutamide - Wikipedia
*Bica does not supress Testo like CPA for example. Is a non-steroidal AntiAndrogen. It is a completely selective antagonist of the AR. Instead, it increases T thus the conversion of T into E2 via aromatase enzyme, that's why Gyno it's the most common side effect of Bica. Just posting this to help. Thank you.
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^ You're very quick, thanks!@Almas
https://www.hairlosstalk.com/interact/threads/safest-antiandrogen-for-your-dick-bicalutamide.123190/Pharmacology of bicalutamide - Wikipedia
Bicalutamide - Wikipedia
*Bica does not supress Testo like CPA for example. Is a non-steroidal AntiAndrogen. It is a completely selective antagonist of the AR. Instead, it increases T thus the conversion of T into E2 via aromatase enzyme, that's why Gyno it's the most common side effect of Bica. Just posting this to help. Thank you.
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Yeah except starting out very low levels of estrogen turn on breast growth cause the body seems geared to actually see all of this as a second puberty instead of racing right away to full feminization. So many things seem backwards in this realm.
Makes a ton of sense. So it basically is has effects like finasteride/dutasteride in the way of increased aromatization so that you may not even need E with it?@Almas
https://www.hairlosstalk.com/interact/threads/safest-antiandrogen-for-your-dick-bicalutamide.123190/Pharmacology of bicalutamide - Wikipedia
Bicalutamide - Wikipedia
*Bica does not supress Testo like CPA for example. Is a non-steroidal AntiAndrogen. It is a completely selective antagonist of the AR. Instead, it increases T thus the conversion of T into E2 via aromatase enzyme, that's why Gyno it's the most common side effect of Bica. Just posting this to help. Thank you!
Agree Janey. Believe me I am trying to read and learn stuff but it is like you are in a huge never-ending Labyrinth. Thank you.