Exploring The Hormonal Route. Hair=life.

JaneyElizabeth

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Sebum does have its good and bad. Too much of a good thing is indeed a bad thing. In moderation, it helps hair by keeping it moisturized and healthy, also protecting it from outside debris and pollution, yet too much will create an environment suitable fo hair loss..




About 5AR Type 1, i am honestly on a fence here. Obviously it still synthesizes T to DHT, so it can be considered "bad" for the average balding joe, yet it also exists in considerable amounts in the brain and liver (as opposed to Type 2).. which surprisingly, only recently that dutasteride was found to be linked to higher chances of diabetes, higher cholesterol, NAFLD / liver enzymes and insulin resistance. It may have been due to its inhibition of 5AR Type 1( which again, exists in considerable amounts in the liver).




If scalp sebum problems are very severe, Nizoral could help quite alot, or better yet, even low-dose Accutane would pack a punch and has higher rates of success than solely relying on inhibiting 5AR Type 1, but that might be just me.
Yes. DHT can lead to excess sebum which can cause inflammation due to over-colonization of yeast and their by-products. Inflammation is the other half of the baldness conundrum but topical estrogen might also help provided an environment more conducive to hair growth.
 

JaneyElizabeth

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BTW, just found a tidbit I've been looking for for a while now. Duta inhibits type 1 by about 50% at 0.5mg/day and by about 80% at 2.5mg/day. (Type 1 is associated with the sebaceous glands)
Is that all? Then maybe more would have solved my dermatitis but ultimately only beard removal did.
 

JaneyElizabeth

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Anyone else attracted to Taki? She defied Newton's Principia related to gravity:

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hair transplant
 

Almas

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Some transwomen can effeciently lower their Testosterone levels to <100 ng/dl with the use of only 2mg E monotherapy (spaced throught the day). 2mg E is by no means a small dose, especially if you haven't done your research well on this.




I suspect that some people can't halt their balding with the use of Bica, because they don't pair Bica with 5ARIs (not that i'm endorsing this) to lower DHT overpowering Bica at the receptors, or it causes an immense Testosterone surge, that overwhelms Bica at receptor-binding, or simply their dosage is too low or they don't give it enough time to work (Bica needs 3 months to even build up to steady state).



150 mg is very high, and he should definitely check on his liver health and enzymes first and foremost.
Of course, Bica must be used with finasteride / Duta
Yes, I'm not very good at estrogen. I thought 2mg was a small dose, but it turned out that it is not. The fact is that transgender people do not consume less than 2 mg, so I decided that this is the minimum that we can use.
In that case, perhaps our choice is 1 click of Estrogel? This equates to 0.75mg E. Hopefully this dose will lower the T, but not too much. We don't need too much feminization, we need balance

But in general, I really hope that 50-75mg of Bica + Duta will be enough. The only problem is that Duta is very expensive. I would like to find not only effective, but also cheap treatment. For example, 50mg Bica + finasteride - I use that now. If this does not help, I will increase the dose to 75mg and try to replace finasteride with dutasteride
 

Almas

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It would be good to lower your T levels from 1200-1500 to 600-800 with estrogel. And block that T with 50mg Bica
 

JaneyElizabeth

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Of course, Bica must be used with finasteride / Duta
Yes, I'm not very good at estrogen. I thought 2mg was a small dose, but it turned out that it is not. The fact is that transgender people do not consume less than 2 mg, so I decided that this is the minimum that we can use.
In that case, perhaps our choice is 1 click of Estrogel? This equates to 0.75mg E. Hopefully this dose will lower the T, but not too much. We don't need too much feminization, we need balance

But in general, I really hope that 50-75mg of Bica + Duta will be enough. The only problem is that Duta is very expensive. I would like to find not only effective, but also cheap treatment. For example, 50mg Bica + finasteride - I use that now. If this does not help, I will increase the dose to 75mg and try to replace finasteride with dutasteride
2mg can reset the axis over time at least for some. Lower levels of estradiol tend to create larger breasts than larger doses because it mimicks cis-female pregnancy. The consensus on the MtF sites is that you need to look into Serms to avoid breast growth yet they are expensive and can be hard to find. So might lessen feminization with less estradiol but you won't lessen breast growth most likely and without female target levels, it might be hard to turn female hair growth on. I started formal HRT on .30mg premarin and that's it and ended up with pretty large breasts especially when correcting for chest width, i.e. when pushed together they are round and huge. I titrated slowly up to only 2.5mg Premarin over four years and never hit targets and had massive breast growth. None of this is straightforward because you are all but literally starting a second female puberty when doing this.

I don't know that this can be done all the way without at least the risk of substantial breast growth. It may be that Primarin and ethinyl estradiol are superior for breast growth which is what MtF's want but they might be better for hair too. @bridgeburn used both I think plus there is Premarin cream which I would like to try since it contains stronger estrogens without liver risk in the long-run. You have to just take a leap of faith that this is right for you. Goddess actually spoke to me and told me that this was my path to healing and rejuvenation. Now, no more hair loss or dermatitis and I look really young with DR helping.
 
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SnortingFinasteride

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It would be good to lower your T levels from 1200-1500 to 600-800 with estrogel. And block that T with 50mg Bica
Holy hell, is your T level really between 1200-1500 ng/dl ?! That's like off the normal maximum limit for the average male..



It could be beneficial to lower that T level and at least get it down to the normal range, 600-800 ng/dl is good enough for a young adult male. The thing with Estrogel though, is that you cannot know the dosage needed to lower T levels to the 600-800 ng/dl range (the body functions in mysterious ways). You would have to take regular blood works and see where your T level and E level stand.



Also bear in mind, the absorption of E gel compared to E pills. The gel absorption can be affected by much more factors, including the area you rub it in / washing the area too early / accidentaly smearing the gel onto clothes ect...
 

SnortingFinasteride

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Is that all? Then maybe more would have solved my dermatitis but ultimately only beard removal did.
It is a good idea that you actually went with the beard removal, since it is not proven that even inhibiting 100% of 5AR Type 1 would even solve such issues. And taking high doses of Dutasteride is just "venturing into the unknown" territory..
 

ReturnOfExtreme

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Now I don't feel like using estrogen. Even 2mg results in thickening of the beber and muscle loss ... Are the thighs enlarged due to adipose tissue, or an overgrowth of the pelvic bone?
In this case, you should increase the dosage of Bica to 75 mg and connect Duta if the current mode does not work. I am confused by the fact that even 150mg of Bica didn’t help people like Jakes, I don’t know what to do in this case ...

I’m using 4mg of E and 25mg of bicalutamide
 

JaneyElizabeth

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It is a good idea that you actually went with the beard removal, since it is not proven that even inhibiting 100% of 5AR Type 1 would even solve such issues. And taking high doses of Dutasteride is just "venturing into the unknown" territory..
Yes and it takes ten years off the face and is synergystic with micro-needling and Estrogel and Retin-A. My beard was always infected and took thirty minutes to remove as it was hard to cut for a razor. I usually needed a straight edge and triple bladed ones. Best decision ever and It might promote hair growth by reducing inflammation and cross-infection between face and scalp.
 

JaneyElizabeth

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Waiting Point Break for the first time. Boy, is that a hair movie. It's hard to remember when my hair looked good wet until recently. Surfers, skiers and skaters need hair!
 

GRme11

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Pls_NW-1

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I think it's quite weird that there are no long-term Bicalutamide users for androgen blockage and/or male pattern baldness. Kinda weird that people got only interested into it since 2018/19. And all those users who started using it then, vanished. But all of them had success with it in terms of halting loss and even regrowing.
 

JaneyElizabeth

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I think it's quite weird that there are no long-term Bicalutamide users for androgen blockage and/or male pattern baldness. Kinda weird that people got only interested into it since 2018/19. And all those users who started using it then, vanished. But all of them had success with it in terms of halting loss and even regrowing.
It took it years to get past the stigma of flutamide in terms of harshness plus, I have detailed a few times how few needed AA's when people used Premarin and ethinyl estradiol because they hit targets easily but then the liver stigma hit all tabs so doctors stopped prescribing enough and so AA's were needed. From what I see, CPA and MPA are straightforward and might work for everyone, bica and spironolactone are based on receptor blocking which creates more sides. I highly doubt that bica is superior than provera in any way really. Those two to me, are phony AA's, while provera, P4 and CPA are true blockers not selective ones and likely to lack sides.

This article details some of the hormonal history and is highly recommended especially for MtF's:
 

Almas

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For 600-800 T, you will need 75-100mg Bica.
50mg bicalutamide blocks - 800ng/dl of testosterone
100mg bicalutamide blocks - 1,600ng/dl of testosterone
150mg bicalutamide blocks - 2,400ng/dl of testosterone

According to DHTcel
Given the increase after taking Bicalutamide
 

Pls_NW-1

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50mg bicalutamide blocks - 800ng/dl of testosterone
100mg bicalutamide blocks - 1,600ng/dl of testosterone
150mg bicalutamide blocks - 2,400ng/dl of testosterone

According to DHTcel
Given the increase after taking Bicalutamide
Yeah right, you still need to adjust the dosage to the T spike.

I can't wait to see your levels after 3 momths xD
 

Almas

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Yeah right, you still need to adjust the dosage to the T spike.

I can't wait to see your levels after 3 momths xD
How can I convert values to ng / dl? In Russia, other meanings when passing tests, I do not understand them
 

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