Exploring The Hormonal Route. Hair=life.

[JaneyElizabeth]

Skin health​

The estrogen receptor, as well as the progesterone receptor, have been detected in the skin, including in keratinocytes and fibroblasts.[62][63] At menopause and thereafter, decreased levels of female sex hormones result in atrophy, thinning, and increased wrinkling of the skin and a reduction in skin elasticity, firmness, and strength.[62][63] These skin changes constitute an acceleration in skin aging and are the result of decreased collagen content, irregularities in the morphology of epidermal skin cells, decreased ground substance between skin fibers, and reduced capillaries and blood flow.[62][63] The skin also becomes more dry during menopause, which is due to reduced skin hydration and surface lipids (sebum production).[62] Along with chronological aging and photoaging, estrogen deficiency in menopause is one of the three main factors that predominantly influences skin aging.[62]

Hormone replacement therapy, consisting of systemic treatment with estrogen alone or in combination with a progestogen, has well-documented and considerable beneficial effects on the skin of postmenopausal women.[62][63] These benefits include increased skin collagen content, skin thickness and elasticity, and skin hydration and surface lipids.[62][63] Topical estrogen has been found to have similar beneficial effects on the skin.[62] In addition, a study has found that topical 2% progesterone cream significantly increases skin elasticity and firmness and observably decreases wrinkles in peri- and postmenopausal women.[63] Skin hydration and surface lipids, on the other hand, did not significantly change with topical progesterone.[63] These findings suggest that progesterone, like estrogen, also has beneficial effects on the skin, and may be independently protective against skin aging.[63]

 

[JaneyElizabeth]

Anyone know why progesterone is P4 and not just P? I assume there are different metabolites that are P1, P2 and P3 as with estrogen. But why isn't DHT called T2? Copyright violations of Arnald's movies?

 

[JaneyElizabeth]

I can easily pull my scalp together from all angles which is supposed to be correlated with a good environment for regrowth.

 

[JaneyElizabeth]

Amazon has none and these companies don't bother to print the gauge on the base or roller so those are useless:

https://www.cosmeticsmegastore.com/us/25-mm-derma-roller-boolavard-tm-titanium-alloy-micro-needle-roller-540-needlesbest-skin-roller/p-13552950-27885146?language=en&ac=cosmeticsmegastore&gclid=CjwKCAiA65iBBhB-EiwAW253W6sSm7gOYDth2MXFBtKPC5_JEUWOvPHw_SNvQ9-4Dk8cQL3whXKWbhoCtOQQAvD_BwE

 

[JaneyElizabeth]

So, 2.5mm roller bought from Cosmetics Megastore for $17 including shipping and no tax apparently so score! I will provide feedback on the 2.5mm gauge.

 

[Derelict]

Anybody have experience with 2mg estriol orally? i know that equivalent to estradiol it is a tiny dose but wondering if it is worth it or not.

 

[JaneyElizabeth]

Anybody have experience with 2mg estriol orally? i know that equivalent to estradiol it is a tiny dose but wondering if it is worth it or not.

I used to use estriol alone and with estradiol as Bi-estro and I think that you need an AA for it to do much hair-wise.

 

[DogoDiLaurentiis]

I'm heading out for a while, but I just want to say, I will be back and I will have completely changed up my regimen.

My 17b estradiol gel arrived recently and I have experienced a remarkable shed due to using it after a very short time, so it's f*****g on. The stuff is legit and I'm fully into a new program that will involve 17b estradiol gel, topical and potentially oral minoxidil (it will be a very low, periodic dose) and topical finasteride as it supposedly does not go systemic to the degree other topicals I've used have.

One thing that I will say about the difference between estrogen and estriol, the latter gave me f*****g headaches if I used it too much. Estriol and estrogen are not the same, similar but different.

I would not recommend using both in tandem if you want hair growth, just go big or go home and use the 17b estradiol.

That's it, I'll be back when I have something to report.

 

[Norwoody]

Agree with Janey, you probably need to take it with an AA. Maybe RU would be strong enough to compliment it.

 

[Derelict]

I used to use estriol alone and with estradiol as Bi-estro and I think that you need an AA for it to do much hair-wise.

I have been taking 200mg spironolactone for nearly two years so im ok in that regard.

 

[Norwoody]

BTW, just found a tidbit I've been looking for for a while now. Duta inhibits type 1 by about 50% at 0.5mg/day and by about 80% at 2.5mg/day. (Type 1 is associated with the sebaceous glands)

 

[Norwoody]

Oh, and if you take it like 2-3x a week it will only inhibit around 15% of type 1 in case anyone is wondering.

 

[Almas]

do you have to stick on bica for life or is it a cycle only?

All life. If you stop taking Bica, you will start to go bald again.

 

[Almas]

Physically weaker? Yeah. Lost muscles? Yeah. Didn’t have those regardless. Getting fat? No, but my weight has increased due to thicker thighs, etc. Erectile dysfunction? Don’t know, don’t use it.

Now I don't feel like using estrogen. Even 2mg results in thickening of the beber and muscle loss ... Are the thighs enlarged due to adipose tissue, or an overgrowth of the pelvic bone?
In this case, you should increase the dosage of Bica to 75 mg and connect Duta if the current mode does not work. I am confused by the fact that even 150mg of Bica didn’t help people like Jakes, I don’t know what to do in this case ...

 

[Almas]

Unless you can take a risk and try to lower your T levels with 0.75mg E from a single click of Estrogel, monitor your T levels and not drop too much. It would be optimal to keep T around 600-800ng / dl. This is a normal level for men, but 50mg of Bica will be sufficient. The problem is that even small doses of E seem to cause muscle loss and hip enlargement.

 

[SnortingFinasteride]

BTW, just found a tidbit I've been looking for for a while now. Duta inhibits type 1 by about 50% at 0.5mg/day and by about 80% at 2.5mg/day. (Type 1 is associated with the sebaceous glands)

Oh, and if you take it like 2-3x a week it will only inhibit around 15% of type 1 in case anyone is wondering.

You are correct. That is why (in my personal opinion) if i were to ever venture towards dutasteride, taking it every other day or every 3 days would yield relatively close results as every day (if not the same results), while paying 1/2 the price or less.



5AR Type 1 is indeed associated with the sebaceous glands, yet strangely enough, inhibiting it doesn't generally result in any improvements regarding acne or oily skin. That is not to say that finasteride or dutasteride didn't help some people with their skin, but Merck did once ran clinical tests with a selective 5AR Type 1 inhibitor (MK-386) that sadly did not differ from placebo..and nevertheless, some people report their skin getting worse with cystic acne and such with the usage of 5ARIs..




I don't exactly know what role does 5AR type 1 play in balding, but if it did play a significant role, wouldn't the "Güevedoce" also experience some form of balding, since they have seemingly functional 5AR type 1 and 3..?

 

[Norwoody]

I'm sure it plays a role, but the question is how significant. I say this empirically, as many users with inflamed and itchy scalps usually have issues with excessive sebum as well. Could be pure correlation I suppose. IMO excessive sebum can only put one at risk for inflammation and fungal cultures, both bad for hair (in scalps prone to balding).

 

[SnortingFinasteride]

Now I don't feel like using estrogen. Even 2mg results in thickening of the beber and muscle loss ... Are the thighs enlarged due to adipose tissue, or an overgrowth of the pelvic bone?
In this case, you should increase the dosage of Bica to 75 mg and connect Duta if the current mode does not work. I am confused by the fact that even 150mg of Bica didn’t help people like Jakes, I don’t know what to do in this case ...

Some transwomen can effeciently lower their Testosterone levels to <100 ng/dl with the use of only 2mg E monotherapy (spaced throught the day). 2mg E is by no means a small dose, especially if you haven't done your research well on this.




I suspect that some people can't halt their balding with the use of Bica, because they don't pair Bica with 5ARIs (not that i'm endorsing this) to lower DHT overpowering Bica at the receptors, or it causes an immense Testosterone surge, that overwhelms Bica at receptor-binding, or simply their dosage is too low or they don't give it enough time to work (Bica needs 3 months to even build up to steady state).



150 mg is very high, and he should definitely check on his liver health and enzymes first and foremost.

 

[SnortingFinasteride]

I'm sure it plays a role, but the question is how significant. I say this empirically, as many users with inflamed and itchy scalps usually have issues with excessive sebum as well. Could be pure correlation I suppose. IMO sebum can only put one at risk for inflammation and fungal cultures, both bad for hair.

Sebum does have its good and bad. Too much of a good thing is indeed a bad thing. In moderation, it helps hair by keeping it moisturized and healthy, also protecting it from outside debris and pollution, yet too much will create an environment suitable fo hair loss..




About 5AR Type 1, i am honestly on a fence here. Obviously it still synthesizes T to DHT, so it can be considered "bad" for the average balding joe, yet it also exists in considerable amounts in the brain and liver (as opposed to Type 2).. which surprisingly, only recently that dutasteride was found to be linked to higher chances of diabetes, higher cholesterol, NAFLD / liver enzymes and insulin resistance. It may have been due to its inhibition of 5AR Type 1( which again, exists in considerable amounts in the liver).




If scalp sebum problems are very severe, Nizoral could help quite alot, or better yet, even low-dose Accutane would pack a punch and has higher rates of success than solely relying on inhibiting 5AR Type 1, but that might be just me.

 

[JaneyElizabeth]

I'm heading out for a while, but I just want to say, I will be back and I will have completely changed up my regimen.

My 17b estradiol gel arrived recently and I have experienced a remarkable shed due to using it after a very short time, so it's f*****g on. The stuff is legit and I'm fully into a new program that will involve 17b estradiol gel, topical and potentially oral minoxidil (it will be a very low, periodic dose) and topical finasteride as it supposedly does not go systemic to the degree other topicals I've used have.

One thing that I will say about the difference between estrogen and estriol, the latter gave me f*****g headaches if I used it too much. Estriol and estrogen are not the same, similar but different.

I would not recommend using both in tandem if you want hair growth, just go big or go home and use the 17b estradiol.

That's it, I'll be back when I have something to report.

Remember that sheds mean that it is working as per the site's owner.