Yes there's lots of positive experiences. but honestly lets be realistic. don't expect a miracle. Some people don't respond to ANYTHING. finasteride, dutasteride, cyproterone, estradiol. no matter.. and many of the ones that do respond don't always post about it and usually become less active. naturally, the ones that don't will post more.
now please keep these thoughts in mind:
-There are even many Mtf's that don't regrow. many do but also many don't. Ive always seen however that it at least doesn't get any worse. Balding is halted in worst case scenario and regrown in best case. Many on this thread claim that they still lose hair even on AAs but never show pics. I've never seen a before and after MTF transition where hairloss progressed. Of course there are many cases where regrowth does happen for transwomen and these get more attention so everybody expects estrogen to guarantee a miracle.. It's possible, It's not guarenteed.
- It is very very hard to regrow long lost hair. especially temples and especially slick bald temples.. but don't understand me wrong. I believe my method gives the best chance for regrowth. But the regrown hair cannot be expected to be exactly the same as it once was. Mine slowly gets more cosmetically noticeable, but even then it grows slower than Normal hair.. It is still recovering even after a year and a half of hormones.. and I take higher doses than most on this thread. the places that were slick bald are like this, the diffusion which was all over the top is normal hair again. But without T / DHT and with high E its absolutely great to know my condition can only get better and not worse.
- There is a competition between E and DHT and the previous years of androgen exposure gives DHT an advantage. Hair which has been dead is not normal hair, its injured. Someone injured can't take a hit as well as someone not injured. I can jump up and down right now without any problem, zero pain. If I sprain my ankle and try a simple small jump then its excruciating pain!!! Something which causes zero damage can cause huge damage when you're already hurt. thats why I believe in the suppression of testosterone in addition to DHT.. finasteride does not removed 100% DHT, It remove what, 70 ish percent by plasma?? maybe 50% in the scalp? I don't know the exact numbers but my point is why f*** with finasteride when dutasteride inhibits more!! If you take estradiol, but not enough to Lower Testosterone in your body and 5ar is produced locally in the scalp then what good is it... REMOVE all that 5ar that you can or there will be antagonization of E and of hair.
1 nM finasteride inhibits DHT synthesis in derma papillae by 86%. (in incubated biopsies) 100nM Estradiol inhibits 60% DHT in DP. Thats 100x the amount of finasteride to get 60% inhibition.. Of course If you were to fill your whole body with estradiol then thats another story and would likely dramatically reduce DHT, it would also reduce testosterone and can do so into castrate range.. But it is unclear how E does inhibit 5ar. they think it inhibits indirectly by affecting androgen metabolism. If this is the case then there should be some synergy with finasteride, or dutasteride which have dose response curves. combining 2 or more mechanisms of methods against DHT is a good strategy.
- The dose matters.. and there is a sh*t ton of individual variation. Some can respond with lower amounts. Some people respond to just finasteride while other keep losing hair on it.. some have regrown with spironolactone. But most need something stronger than spironolactone I believe. And Women get better hair with increased anagen during pregnancy. Really think about that. non pregnant women have high estradiol already compared to men.. yet going from high E to very high E gives better hair!! It may not only be the amount contributing but that the levels are going up consistently keeping more consistent anagen..and people on this thread usually don't even take trans-level doses as I do.
- Don't let even 1 molecule of DHT form!!!! my previous points tie into this.. It is very hard to regrow hair. the hair is injured therefore more sensitive, needs more of a boost. And I am sad to say but even though it is possible to regrow hair there is likely a point of no return.. HRT can give back 5 to 10 years of hair but even then its no guareentee.. If you really want your hair back, I suggest throwing everything that you f*****g can at it and don't hold back. Yes, add an androgen receptor blocker. You'd require way less estradiol when receptors are blocked and without antagonization of androgens. In the beginning i was on 100mg cypo, and a small amount of estrogel on temples.. if i took even a small amount of estrogen I felt it in the nipples.. Blocked receptors are a powerful thing even women and eunuchs don't have Blocked receptors..
Cyproterone is stronger than spironolactone, thats why I used cypro. dutasteride is stronger than finasteride , choose dutasteride. If you want to f*** around with weaker stuff, and it doesn't work then go to something stronger..and keep going until max you are willing to go.. use Estradiol pill combined with the gel.. The pill gives a higher initial E spike and the gel gives more stable levels.. Its good to combine these pros and cons.. Take higher amounts if you need. Choose oral minoxidil over topical.. be patient, I don't think you've used this stuff too long. give it at least 3 to 6 months then assess.. if higher estradiol doesn't work out, Consider Ethynlestradiol, found in Diane-35, EthynE is stronger at activating E receptors than estradiol. (though one study showed estradiol inhibits 5ar while EE doesn't.) some have regrown hair with that. (like that notorious Thai boy, Twohen).. pros and cons, thats why I take estradiol everyday and pop a Diane -35 once a week.
keep going agressively.. Don't even think about getting your hopes up unless you fight with everything you got. Humanity goes to the moon before curing baldness.. If you don't respond to all above then you probably need stem cells. Estradiol interects with stem cells in the follicles. Now consider more for the future: progesterone, topical hydrocortisone, dermaneedling, estrofem, estrogel, cyproterone, dutasteride, oral min, topical min, Diane-35, topical Dexamethasone.. All of that has synergy. Combine all that and you'll get better.