Geez I wish there was a for dunnies version of these abstracts. Anywho this is my takeaway from it:
"The same group found that in cultured human,
nonbalding scalp dermal papilla cells, the two ERs exhibited different expression patterns,
ERβ showing strong nuclear expression, and ERα granular cytoplasmic expression (24). This different distribution may contribute to a variable E2 responsiveness (254)."
More E receptors = better chance of not going bald?
"ERs are more widely expressed, and importantly, ERβ is strongly expressed in the bulge region of the outer root sheath. This region contains stem cells for
hair follicle keratinocytes that regenerate the follicle during the anagen phase. This suggests that these epithelial stem cells are targets for estrogen action."
So the more E = the better chance that hair will grow? Especially if you have more E receptors?
"in anagen VI follicles microdissected from
frontotemporal skin, there was a remarkable distribution difference between male and female hair follicles from frontotemporal scalp skin: ERβ immunoreactivity was found in male scalp hair follicles predominantly in the matrix keratinocytes, whereas in female hair follicles, ERβ immunoreactivity was predominantly found in the dermal papilla fibroblasts (10)."
Does this mean men actually have great potential to grow hair on the hairline if they only produced more damn estrogen??
"However, these findings in mice contrast with long-standing clinical experience in the topical application of E2 to the human scalp. For human scalp hair, topical E2 has long been used in the management of telogen effluvium and androgenetic alopecia, especially in women (29, 58, 275). Although this remains to be unequivocally demonstrated
in vivo,
E2 has been proposed to decrease the telogen rate and to prolong the anagen phase in human scalp skin, justifying the use of topical E2 in the management of hair loss characterized premature catagen entry, such as androgenetic alopecia and telogen effluvium (29, 30, 88, 275–277).
So any baldness cures done on mice with success likely don't hold any weight with human hair since the genes are too different?
Cripes this stuff is complicated, no wonder it's been thousands of years and the cure has not been found.
